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Radiological assessment of skull base changes in children with syndromic craniosynostosis: role of “minor” sutures

  • Paediatric Neuroradiology
  • Published:
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Abstract

Introduction

This study aims to identify the premature synostosis of “major” and “minor” sutures of the four “sutural arches” of the skull and to perform a morphometric analysis in children with syndromic craniosynostosis in order to evaluate changes in the skull base linked with premature suture synostosis.

Methods

We reviewed multiplanar high-resolution CT images, implemented with 3D reconstructions, from 18 patients with complex syndromic craniosynostosis and compared them with 18 age-matched healthy subjects. We assessed the calvarial sutures and their extension to the skull base, and then we correlated specific types of synostosis with the size, shape and symmetry of the cranial fossae.

Results

We found a marked asymmetry of the skull base growth in all patients. The synostotic involvement around the coronal ring caused a reduction in the growth of the anterior and middle fossae. The size of the posterior cranial fossa was related not only to “major” but also to “minor” suture synostosis of the lambdoid and parieto-squamosal arches.

Conclusion

Changes in the skull base and craniofacial axis symmetry are due to structural and functional relationships between “major” and “minor” skull sutures, suggesting a structural and functional relationship between the neurocranium and basicranium.

The early recognition of prematurely closed skull base sutures may help clinicians and neurosurgeons to establish correct therapeutic approaches.

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Ethical standards and patient consent

We declare that all human studies have been approved by the local ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. We declare that all patients gave informed consent prior to inclusion in this study.

Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Institute of Radiology, Università Cattolica Sacro Cuore, L.go A. Gemelli 8, 00168, Rome, Italy

    Rosalinda Calandrelli, Gabriella D’Apolito, Simona Gaudino, Mariangela Stefanetti & Cesare Colosimo

  2. Institute of Neurosurgery, Università Cattolica Sacro Cuore, Rome, Italy

    Luca Massimi & Concezio Di Rocco

Authors
  1. Rosalinda Calandrelli
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  2. Gabriella D’Apolito
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  3. Simona Gaudino
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  4. Mariangela Stefanetti
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  5. Luca Massimi
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  6. Concezio Di Rocco
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  7. Cesare Colosimo
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Corresponding author

Correspondence to Rosalinda Calandrelli.

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Calandrelli, R., D’Apolito, G., Gaudino, S. et al. Radiological assessment of skull base changes in children with syndromic craniosynostosis: role of “minor” sutures. Neuroradiology 56, 865–875 (2014). https://doi.org/10.1007/s00234-014-1392-5

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  • DOI: https://doi.org/10.1007/s00234-014-1392-5

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