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Eag1 Voltage-Dependent Potassium Channels: Structure, Electrophysiological Characteristics, and Function in Cancer

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Abstract

Eag1 (ether-à-go-go-1), a member of the voltage-dependent potassium channel family, is expressed mainly in the brain, and at low levels in placenta, testis, and adrenal gland, and only transiently in myoblasts. Recently, several studies have suggested that Eag1 is selectively expressed in various tumor tissues. Eag1 plays important roles in tumor proliferation, malignant transformation, invasion, metastasis, recurrence, and prognosis. Therefore, it has become a new molecular target for tumor diagnosis, prognosis evaluation, and tumor-targeted therapy. This review provides information about the current progress in understanding Eag1 structure, electrophysiological characteristics, and role in cancer.

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Acknowledgements

This work was supported by the Natural Science Fund for Distinguished Young Scholars of the Hebei Province of China (Grant No. C2015202340 to HA), the Foundation for Outstanding Talents of Hebei Province of China (Grant No. C201400305 to HA), and the National Natural Science Foundation of China (Grant Nos. 11247010 to HA, 11475053 to YZ, 31400711 to YC).

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    1. School of Electrical Engineering, Hebei University of Technology, Tianjin, 300401, People’s Republic of China

      Xuzhao Wang, Shuai Guo & Yong Zhan

    2. Key Laboratory of Molecular Biophysics, School of Sciences, Hebei University of Technology, Tianjin, 300401, Hebei Province, People’s Republic of China

      Xuzhao Wang, Yafei Chen, Yuhong Zhang, Shuai Guo, Li Mo, Hailong An & Yong Zhan

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    Xuzhao Wang and Yafei Chen contributed equally to this work.

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    Wang, X., Chen, Y., Zhang, Y. et al. Eag1 Voltage-Dependent Potassium Channels: Structure, Electrophysiological Characteristics, and Function in Cancer. J Membrane Biol 250, 123–132 (2017). https://doi.org/10.1007/s00232-016-9944-8

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