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Elevation of alkaline phosphatase and long-term drug therapy for cystic fibrosis

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The authors confirm that the data supporting the findings of this study are available within the article or its supplementary materials.

References

  1. Kent JR, Almond MK, Dhillon S (2001) Azithromycin: an assessment of its pharmacokinetics and therapeutic potential in CAPD. Perit Dial Int 21(4):372–7

  2. Sugie M, Asakura E, Zhao YL, Torita S, Nadai M, Baba K, Kitaichi K, Takagi K, Takagi K, Hasegawa T (2004) Possible involvement of the drug transporters P glycoprotein and multidrug resistance-associated protein Mrp2 in disposition of azithromycin. Antimicrob Agents Chemother 48(3):809–814

    Article  CAS  Google Scholar 

  3. Nguyen TD, Markova S, Liu W, Gow JM, Baldwin RM, Habashian M, Relling MV, Ratain MJ, Kroetz DL (2013) Functional characterization of ABCC2 promoter polymorphisms and allele-specific expression. Pharmacogenomics J 13(5):396–402

    Article  CAS  Google Scholar 

  4. Robertson SM, Luo X, Dubey N, Li C, Chavan AB, Gilmartin GS, Higgins M, Mahnke L (2015) Clinical drug-drug interaction assessment of ivacaftor as a potential inhibitor of cytochrome P450 and P-glycoprotein. J Clin Pharmacol 55(1):56–62

    Article  CAS  Google Scholar 

  5. Howsare MM, El-Kersh K (2017) Isolated extreme elevation of alkaline phosphatase associated with lumacaftor/ivacaftor therapy: first report. Am J Respir Crit Care Med 195:A1509

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Authors and Affiliations

  1. Department of Intensive Care, Cliniques St-Luc, Université Catholique de Louvain, Avenue Hippocrate, 10, Brussels, 1200, Belgium

    Quentin Delmez, Pierre-François Laterre & Philippe Hantson

  2. Department of Clinical Chemistry, Cliniques St-Luc, Université Catholique de Louvain, Brussels, 1200, Belgium

    Vincent Haufroid

  3. Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Université Catholique de Louvain, Brussels, 1200, Belgium

    Vincent Haufroid & Philippe Hantson

  4. Department of Pneumology, Cliniques St-Luc, Université Catholique de Louvain, Brussels, 1200, Belgium

    Sophie Gohy

  5. Cystic Fibrosis Reference Center, Cliniques St-Luc, Université Catholique de Louvain, Brussels, 1200, Belgium

    Sophie Gohy

Authors
  1. Quentin Delmez
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  2. Vincent Haufroid
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  3. Sophie Gohy
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  4. Pierre-François Laterre
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  5. Philippe Hantson
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Corresponding author

Correspondence to Philippe Hantson.

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The patient’s relatives gave written informed consent for publication of the case report.

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The authors declare no competing interests.

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Delmez, Q., Haufroid, V., Gohy, S. et al. Elevation of alkaline phosphatase and long-term drug therapy for cystic fibrosis. Eur J Clin Pharmacol 78, 699–701 (2022). https://doi.org/10.1007/s00228-021-03272-0

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  • DOI: https://doi.org/10.1007/s00228-021-03272-0

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