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Correlation between proton pump inhibitors and risk of pyogenic liver abscess

  • Pharmacoepidemiology and Prescription
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Abstract

Background/objective

Little is known about the relationship between proton pump inhibitors use and pyogenic liver abscess. The objective of this study was to evaluate the correlation between proton pump inhibitors use and pyogenic liver abscess in Taiwan.

Methods

This was a population-based case-control study using the database of the Taiwan National Health Insurance Program since 2000 to 2011. Subjects aged 20 to 84 who experienced their first episode of pyogenic liver abscess were enrolled as the case group (n = 1372). Randomly selected subjects aged 20 to 84 without pyogenic liver abscess were enrolled as the control group (n = 1372). Current use, early use, and late use of proton pump inhibitors was defined as subjects whose last one tablet for proton pump inhibitors was noted ≤30 days, between 31 to 90 days and ≥91 days before the date of admission for pyogenic liver abscess. Subjects who never received a prescription for proton pump inhibitors were defined as nonusers of proton pump inhibitors. A multivariable unconditional logistic regression model was used to measure the odds ratio and 95% confidence interval to evaluate the correlation between proton pump inhibitors use and pyogenic liver abscess.

Results

After adjusting for confounders, the adjusted odds ratio of pyogenic liver abscess was 7.59 for subjects with current use of proton pump inhibitors (95% confidence interval 5.05, 11.4), when compared with nonusers.

Conclusions

Current use of proton pump inhibitors is associated with a greater risk of pyogenic liver abscess.

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Acknowledgements

This study is supported in part by Taiwan Ministry of Health and Welfare Clinical Trial Center (MOHW106-TDU-B-212-113004). This funding agency did not influence the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Author information

Author notes

  1. Hsien-Feng Lin, Kuan-Fu Liao, and Ching-Mei Chang contributed equally to this study.

Authors and Affiliations

  1. School of Chinese Medicine, China Medical University, Taichung, Taiwan

    Hsien-Feng Lin

  2. Department of Family Medicine, China Medical University Hospital, No 2, Yuh-Der Road, Taichung City, 404, Taiwan

    Hsien-Feng Lin & Shih-Wei Lai

  3. Department of Internal Medicine, Taichung Tzu Chi General Hospital, Taichung, Taiwan

    Kuan-Fu Liao

  4. College of Medicine, Tzu Chi University, Hualien, Taiwan

    Kuan-Fu Liao

  5. Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan

    Kuan-Fu Liao

  6. Department of Nursing, Tungs’ Taichung Metro Habor Hospital, Taichung, 435, Taiwan

    Ching-Mei Chang

  7. College of Medicine, China Medical University, Taichung, Taiwan

    Cheng-Li Lin & Shih-Wei Lai

  8. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

    Cheng-Li Lin

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  1. Hsien-Feng Lin
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  2. Kuan-Fu Liao
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Contributions

Hsien-Feng Lin initiated the draft of the article and revised the article.

Kuan-Fu Liao, Ching-Mei Chang, and Cheng-Li Lin conducted the data analysis and revised the article.

Shih-Wei Lai planned and conducted this study. He contributed to the conception of the article, initiated the draft of the article, and revised the article.

Corresponding author

Correspondence to Shih-Wei Lai.

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Lin, HF., Liao, KF., Chang, CM. et al. Correlation between proton pump inhibitors and risk of pyogenic liver abscess. Eur J Clin Pharmacol 73, 1019–1025 (2017). https://doi.org/10.1007/s00228-017-2256-9

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  • DOI: https://doi.org/10.1007/s00228-017-2256-9

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