Skip to main content
Log in

Apolipoprotein E (APOE) and warfarin dosing in an Italian population

  • Letter to the Editors
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Landefeld C, Beyth R (1993) Anticoagulant-related bleeding: clinical epidemiology, prediction and prevention. Am J Med 95:315–328, DOI:10.1016/0002-9343(93)10285-w

    Google Scholar 

  2. Bell RG, Sadowski JA, Matschiner JT (1972) Mechanism of action of warfarin. Warfarin and metabolism of vitamin K1. Biochemistry 11:1959–1961

    Article  PubMed  CAS  Google Scholar 

  3. Berkner KL, Runge KW (2004) The physiology of vitamin K nutriture and vitamin K-dependent protein function in atherosclerosis. J Thromb Haemost 2:2118–2132

    Article  PubMed  CAS  Google Scholar 

  4. Lubetsky A, Dekel-Stern E, Chetrit A, Lubin F, Halkin H (1999) Vitamin K intake and sensitivity to warfarin in patients consuming regular diets. Thromb Haemost 81:396–399

    PubMed  CAS  Google Scholar 

  5. Wells P, Holbrook A, Crowther N, Hirsh J (1994) Interactions of warfarin with drugs and food. Ann Intern Med 121:676–683

    PubMed  CAS  Google Scholar 

  6. Kohlmeier M, Salomon A, Saupe J, Shearer MJ (1996) Transport of vitamin K to bone in humans. J Nutr 126:1192S–1196S

    PubMed  CAS  Google Scholar 

  7. Rocchi A, Pellegrini S, Siciliano G, Murri L (2003) Causative and susceptibility genes for Alzheimer’s disease: a review. Brain Res Bull 61:1–24, DOI.org/10.1016/s.361-9230(03)00067-4

    Article  PubMed  CAS  Google Scholar 

  8. Weintraub MS, Eisenberg S, Breslow JL (1987) Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E. J Clin Invest 80:1571–1577

    Article  PubMed  CAS  Google Scholar 

  9. Saupe J, Shearer MJ, Kohlmeier M (1993) Phylloquinone transport and its influence on gamma-carboxyglutamate residues of osteocalcin in patients on maintenance hemodialysis. Am J Clin Nutr 58:204–208

    PubMed  CAS  Google Scholar 

  10. Kohlmeier M, Saupe J, Drossel HJ, Shearer MJ (1995) Variation of phylloquinone (vitamin K1) concentrations in hemodialysis patients. Thromb Haemost 74:1252–1254

    PubMed  CAS  Google Scholar 

  11. O’Reilly RA (1974) Studies on the optical enantiomorphs of warfarin in man. Clin Pharmacol Ther 16:348–354

    PubMed  CAS  Google Scholar 

  12. Kaminsky L, Zhang Z (1997) Human P450 metabolism of warfarin. Pharmacol Ther 73:67–74

    Article  PubMed  CAS  Google Scholar 

  13. Daly AK, King BP (2003) Pharmacogenetics of oral anticoagulants. Pharmacogenetics 13:247–252

    Article  PubMed  CAS  Google Scholar 

  14. Kohnke H, Sörlin K, Granath G, Wadelius M (2005) Warfarin dose related to apolipoprotein E (APOE) genotype. Eur J Clin Pharmacol 61:381–388, DOI:10.1007/s00228-005-0936-3

    Google Scholar 

  15. Scordo MG, Pengo V, Spina E, Dahl ML, Gusella M, Padrini R (2002) Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance. Clin Pharmacol Ther 72:702–710, DOI:10.1067/mcp.2002.129321

    Google Scholar 

  16. Ewbank DC (2004) The APOE gene and differences in life expectancy in Europe. J Gerontol A Biol Sci Med Sci 59:16–20

    PubMed  Google Scholar 

  17. Eggertsen G, Tegelman R, Ericsson S, Angelin B, Berglund L (1993) Apolipoprotein E polymorphism in a healthy Swedish population: variation of allele frequency with age and relation to serum lipid concentrations. Clin Chem 39:2125–2129

    PubMed  CAS  Google Scholar 

Download references

Acknowledgements

We thank Professor Martin Kohlmeier, University of North Carolina for the idea to study APOE. Niclas Eriksson is acknowledged for his statistical support. This study was funded by the Swedish Society of Medicine, the Swedish Research Council and Foundation for Strategic Research, the Clinical Research Support (ALF) at Uppsala University, and the foundations Swedish Heart and Lung, Tore Nilson, Marcus Borgström and Ländell. The sponsors had no role in the study design, data collection, data analysis, data interpretation or writing of the report.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mia Wadelius.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kohnke, H., Scordo, M.G., Pengo, V. et al. Apolipoprotein E (APOE) and warfarin dosing in an Italian population. Eur J Clin Pharmacol 61, 781–783 (2005). https://doi.org/10.1007/s00228-005-0982-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00228-005-0982-x

Keywords

Navigation