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Age-related Changes in Body Composition, Hydroxyproline, and Creatinine Excretion in Normal Women

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Abstract.

We have made a cross-sectional study of relationships among age, whole body bone mineral content (WBBMC), and non-bone lean body mass (NBLBM) measured by dual energy X-ray absorptiometry (DXA), and daily excretion of hydroxyproline (OHP) and creatinine (Cr) in a group of normal women. WBBMC fell with age from the 6th decade, whereas NBLBM was almost constant. Creatinine excretion fell with age from the 5th decade until the 9th, to a much greater degree than NBLBM, reaching a nadir in the 8th decade. Daily excretion of hydroxyproline showed a peak in the 6th decade and fell moderately thereafter. The greater fall of creatinine compared with hydroxyproline resulted in rising OHP/Cr ratios with advancing age, in contrast to the pattern of hydroxyproline excretion. The use of creatinine as a correction for urine dilution or for lean body mass (LBM) in assays for markers of bone turnover must therefore be viewed with caution.

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Received: 30 July 1997 / Accepted: 9 July 1998

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Worsfold, M., Davie, M. & Haddaway, M. Age-related Changes in Body Composition, Hydroxyproline, and Creatinine Excretion in Normal Women. Calcif Tissue Int 64, 40–44 (1999). https://doi.org/10.1007/s002239900576

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  • DOI: https://doi.org/10.1007/s002239900576

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