Abstract
Nutritional factors can elevate the concentration of homocysteine in plasma, which is regarded as a risk indicator for cardiovascular events and other degenerative diseases. Although alimentary methionine is believed to be the main source for plasma homocysteine, the literature is lacking information about the homocysteine content of daily food. In this paper, the total homocysteine content of some commercially available food items such as tuna, swine liver, roquefort cheese, coffee, beer and white bread was measured by RP-HPLC with fluorescence detection after pre-column derivatization with a thiol-specific sulfonylbenzofuran, namely 7-benzo-2-oxa-1,3-diazole-4-sulfonic acid (SBD-F). With the exception of coffee, all examined food contained homocysteine in amounts between 30 and 950 μg per kg, which was 2,000–10,000-fold compared to the methionine content of the respective food. Based on a hypothetical daily consumption of the investigated foods, a maximum daily intake of homocysteine ranging from 400 to 700 μg or 3–5 μmol could be estimated. Compared to plasma homocysteine levels of 6–9 μmol/l, we conclude that the amount of alimentary homocysteine has only a very slight significant impact on the plasma homocysteine level even if complete resorption of the thiol compound is assumed.
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References
De Bree A, Verschuren WM, Kromhout D, Kluijtmans LA, Blom HJ (2002) Pharmacol Rev 54:599–618
van Guldener C, Stam F, Stehouwer CD (2005) Clin Chem Lab Med 43:1026–1031
Allen RH, Stabler SP, Lindenbaum J (1998) Eur J Pediatr 157:S122–S126
El Khairy L, Vollset SE, Refsum H, Ueland PM (2003) Am J Clin Nutr 77:467–472
Ingec M, Borekci B, Kadanali S (2005) Tohoku J Exp Med 206:225–231
Blom HJ (1998) Eur J Pediatr 157:S131–S134
Herrmann W, Obeid R (2005) Clin Chem Lab Med 43:1039–1047
Bellamy MF, McDowell IF, Ramsey MW, Brownlee M, Bones C, Newcombe RG, Lewis MJ (1998) Circulation 98:1848–1852
Finkelstein JD (1998) Eur J Pediatr 157:S40–S44
Kloor D, Stumvoll W, Schmid H, Kompf J, Mack A, Osswald H (2000) J Histochem Cytochem 48:211–218
Refsum H, Guttormsen AB, Fiskerstrand T, Ueland PM (1998) Eur J Pediatr 157:S45–S49
Fowler B (2001) Transport and tissue distribution of homocysteine and related S-adenosyl compounds. In: Carmel R, Jacobsen DW (eds) Homocysteine in health and disease. Cambridge University Press, Cambrigde
Demirkol O, Adams C, Ercal N (2004) J Agric Food Chem 52:8151–8154
Sakamoto A, Nishimura Y, Ono H, Sakura N (2002) Pediatr Int 44:409–413
Souci SW, Fachmann W, Kraut H (2006) Die Zusammensetzung der Lebensmittel: Nährwert-Tabellen. Wissenschaftliche Verlagsgesellschaft, Stuttgart, 3. Auflage (2006)
Imai K, Toyo’oka T, Watanabe Y (1983) Anal Biochem 128:471–473
Loncar R, Flesche CW, Deussen A (1997) J Mol Cell Cardiol 29:1289–1305
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Pexa, A., Fischer, K., Deussen, A. et al. Homocysteine in food. Eur Food Res Technol 226, 933–935 (2008). https://doi.org/10.1007/s00217-007-0583-2
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DOI: https://doi.org/10.1007/s00217-007-0583-2