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MXene-based composites as an electrochemical sensor for ultrasensitive determination of ofloxacin

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Abstract

Sensitive determination of ofloxacin (OFL) is very essential for human health and environmental protection. Here, a novel composite of gold nanoparticles(nAu)@MXene(Ti3C2Tx)/poly-p-aminobenzene sulfonic acid (PABSA) was fabricated on the surface of glassy carbon electrode (GCE) and used to sensitively determine OFL. The results of experiments showed that the obtained nAu@Ti3C2Tx/PABSA/GCE electrode could be used as an electrochemical sensor to directly detect ofloxacin (OFL) by differential pulse voltammetry (DPV). Under the optimal conditions, the proposed electrode displayed a broader linear range and a lower detection limit (LOD) for OFL determination when it was compared to those similar sensors. The linear range was from 5.0 × 10−8 to 5.0 × 10−4 mol/L and the LOD was 3.7 × 10−8 mol/L (S/N = 3). The nAu@Ti3C2Tx/PABSA/GCE electrode also showed good selectivity, repeatability, and reproducibility. Finally, the proposed electrode was used to detect OFL in commercial samples by the standard addition method. The obtained recovery was from 97.3% and 105.7% showing its potential applications in actual sample analysis.

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Funding

This work was supported by the Nature Science Foundation of Liaoning Province (No. 2021-MS-273), Liaoning BaiQianWan Talents Program (No. 2020921109), High-end Research Incubation Scheme of Liaoning Normal University (No. GD20L001), and National College Students Innovation and Entrepreneurship Training Program (No. 202210165027).

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  1. Zuan Yang and Jing Hu contributed equally.

Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, 116029, China

    Zuan Yang, Jing Hu, Xiaoyu Zhang, Huimin Yang, Peiran Meng, Huanying Zhao & Yue Sun

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  1. Zuan Yang
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  2. Jing Hu
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  3. Xiaoyu Zhang
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Contributions

Zuan Yang: data curation, writing—original draft preparation. Jing Hu: data curation, writing—original draft preparation. Xiaoyu Zhang: data curation, writing—original draft preparation. Huimin Yang: formal analysis, writing—reviewing and editing. Peiran Meng: formal analysis, writing—reviewing and editing. Huanying Zhao: formal analysis, writing—reviewing and editing. Yue Sun: conceptualization, methodology.

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Correspondence to Yue Sun.

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Yang, Z., Hu, J., Zhang, X. et al. MXene-based composites as an electrochemical sensor for ultrasensitive determination of ofloxacin. Anal Bioanal Chem 415, 157–166 (2023). https://doi.org/10.1007/s00216-022-04402-y

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