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A highly selective and sensitive dopamine and uric acid biosensor fabricated with functionalized ordered mesoporous carbon and hydrophobic ionic liquid

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Abstract

An ordered mesoporous carbon material functionalized with carboxylic acid groups was synthesized. It was characterized by powder X-ray diffraction, transmission electron microscopy, Fourier transform IR spectroscopy and N2 adsorption/desorption. Furthermore, this material was used to modify an electrode surface combined with a hydrophobic ionic liquid. The functionalized ordered mesoporous carbon/ionic liquid gel modified electrode shows excellent electrocatalytic performances for the oxidation of dopamine, uric acid and ascorbic acid. The presence of the ionic liquid promotes the electron transfer. Linear responses for dopamine and uric acid were obtained in the ranges of 0.1 to 500 μM and from 0.1 to 100 μM with detection limits of 4.1 and 2.5 nM (signal-to-noise ratio of 3), respectively, under optimum conditions. A quick and sensitive biosensor based on functionalized ordered mesoporous carbon and an ionic liquid has been developed for the first time for the detection of dopamine and uric acid in the presence of a large amount of ascorbic acid.

Fig. DPV curves recorded at f-OMC/IL-gel modified electrode in pH 7.0 PBS buffer solution containing 2 mΜ AA, 20 μM UA and different concentrations of DA (from a to h): 0.5, 1, 2.5, 5, 10, 25, 50 and 100 μM.

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Acknowledgements

The authors are grateful for the financial support from the Key Disciplines of Shanghai Municipal Education Commission (no. J50102) and the Graduate Innovation Fund of Shanghai University (no. SHUCX092029).

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Authors and Affiliations

  1. Department of Chemistry, College of Science, Shanghai University, Shanghai, 200444, China

    Junping Dong, Yanyan Hu, Jiaqiang Xu & Yinjuan Xu

  2. State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, 200050, China

    Jiaqiang Xu

  3. State Key Lab of Metal Matrix Composites, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai, 200240, China

    Shenmin Zhu

Authors
  1. Junping Dong
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  2. Yanyan Hu
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  3. Shenmin Zhu
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  4. Jiaqiang Xu
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  5. Yinjuan Xu
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Correspondence to Junping Dong or Jiaqiang Xu.

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Dong, J., Hu, Y., Zhu, S. et al. A highly selective and sensitive dopamine and uric acid biosensor fabricated with functionalized ordered mesoporous carbon and hydrophobic ionic liquid. Anal Bioanal Chem 396, 1755–1762 (2010). https://doi.org/10.1007/s00216-009-3423-3

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  • DOI: https://doi.org/10.1007/s00216-009-3423-3

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