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Multi-residue analytical methods using LC-tandem MS for the determination of pharmaceuticals in environmental and wastewater samples: a review

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Abstract

Multi-residue analytical methodologies are becoming the preferred and required tools against single group analysis, as they provide wider knowledge about the occurrence of pharmaceuticals in the environment necessary for further study of their removal, partition and ultimate fate. However, simultaneous analysis of compounds from different groups with quite different physico-chemical characteristics requires a compromise in the selection of experimental conditions, which in some cases are not the best conditions for all the analytes studied. In this article, an overview of analytical methodologies focusing on the simultaneous determination of acidic, neutral and basic compounds belonging to different therapeutical classes is presented. The state-of-the-art of LC-MS/MS for multi-class analysis is reviewed, highlighting the specific requirements for such analysis.

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Acknowledgements

This work was financially supported by the European Union EMCO project (INCO-CT-2004-509188) and by the Spanish Ministerio de Ciencia y Tecnología (EVITA project-CTM2004-06265-C03-01). M. Gros acknowledges the grant from the Spanish MCyT (CTM2004-06265-C03-01).

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Authors and Affiliations

  1. Department of Environmental Chemistry, IIQAB-CSIC, c/Jordi Girona 18-26, 08034, Barcelona, Spain

    Meritxell Gros, Mira Petrović & Damià Barceló

  2. Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluis Companys 23, 80010, Barcelona, Spain

    Mira Petrović

Authors
  1. Meritxell Gros
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  2. Mira Petrović
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  3. Damià Barceló
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Correspondence to Mira Petrović.

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Gros, M., Petrović, M. & Barceló, D. Multi-residue analytical methods using LC-tandem MS for the determination of pharmaceuticals in environmental and wastewater samples: a review. Anal Bioanal Chem 386, 941–952 (2006). https://doi.org/10.1007/s00216-006-0586-z

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  • DOI: https://doi.org/10.1007/s00216-006-0586-z

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