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Capillary electrophoresis with field-enhanced stacking for rapid and sensitive determination of strychnine and brucine

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Abstract

A new capillary electrophoresis procedure with field-enhanced stacking concentration for the analysis of strychnine and brucine is established. After optimization of the separation and concentration conditions, the two alkaloids can be separated within 5 min and quantified with high sensitivity (The detection limits were 1.0 ng mL−1 for strychnine and 1.4 ng mL−1 for brucine). The method was useful for qualitative and quantitative analysis of strychnine and brucine in Strychnos nux-vomica L with recovery of 105.1% for strychnine and 98.4% for brucine.

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Acknowledgements

The financial support of National Nature Science Foundation of China (No. 20275014) is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, Lanzhou University, 730000, Lanzhou, PR China

    Jiyou Zhang, Shufang Wang, Xingguo Chen, Zhide Hu & Xiao Ma

  2. National Laboratory of Applied Organic Chemistry, 730000, Lanzhou, PR China

    Zhide Hu

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  1. Jiyou Zhang
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  2. Shufang Wang
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  3. Xingguo Chen
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  4. Zhide Hu
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  5. Xiao Ma
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Correspondence to Zhide Hu.

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Zhang, J., Wang, S., Chen, X. et al. Capillary electrophoresis with field-enhanced stacking for rapid and sensitive determination of strychnine and brucine. Anal Bioanal Chem 376, 210–213 (2003). https://doi.org/10.1007/s00216-003-1852-y

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  • DOI: https://doi.org/10.1007/s00216-003-1852-y

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