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A cognitive model-based approach to testing mechanistic explanations for neuropsychological decrements during tobacco abstinence

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Abstract

Rationale

Cigarette smokers often experience cognitive decrements during abstinence from tobacco, and these decrements may have clinical relevance in the context of smoking cessation interventions. However, limitations of the behavioral summary statistics used to measure cognitive effects of abstinence, response times (RT) and accuracy rates, may restrict the field’s ability to identify robust abstinence effects on task performance and test mechanistic hypotheses about the etiology of these cognitive changes.

Objectives

The current study explored whether a measurement approach based on mathematical models of cognition, which make the cognitive mechanisms necessary to perform choice RT tasks explicit, would be able to address these limitations.

Methods

The linear ballistic accumulator model (LBA: Brown and Heathcote, Cogn Psychol 57(3):153-178, 2008) was fit to an existing data set from a study that evaluated the impact of overnight abstinence on flanker task performance.

Results

The model-based analysis provided evidence that smokers’ rates of mind wandering increased during abstinence, and was able to index this effect while controlling for participants’ strategy changes that were related to the specific experimental paradigm used.

Conclusion

Mind wandering is a putative explanation for cognitive withdrawal symptoms during smoking cessation and may be indexed using the LBA. More broadly, the use of formal model-based analyses in future research on this topic has the potential to allow for strong and specific tests of mechanistic explanations for these symptoms.

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Notes

  1. The participant with missing PANAS data in the smoking condition was also excluded from the analysis using Δdeadline as a covariate so results from this analysis could be properly compared with the one using ΔPANAS-NA.

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Acknowledgements

Andrew Heathcote would like to acknowledge the Australian Research Council grant DP160101891 for supporting his work on this project.

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Authors and Affiliations

  1. Department of Psychiatry, University of Michigan, Rachel Upjohn Building, Ann Arbor, MI, 48109, USA

    Alexander Weigard

  2. Department of Psychology, Penn State University, University Park, Hobart, PA, 16801, USA

    Cynthia Huang-Pollock & Andrew Heathcote

  3. The State University of New York at Buffalo, New York, USA

    Larry Hawk Jr

  4. The Johns Hopkins University School of Medicine, Baltimore, USA

    Nicolas J. Schlienz

Authors
  1. Alexander Weigard
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  2. Cynthia Huang-Pollock
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  3. Andrew Heathcote
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  4. Larry Hawk Jr
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  5. Nicolas J. Schlienz
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Correspondence to Alexander Weigard.

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Weigard, A., Huang-Pollock, C., Heathcote, A. et al. A cognitive model-based approach to testing mechanistic explanations for neuropsychological decrements during tobacco abstinence. Psychopharmacology 235, 3115–3124 (2018). https://doi.org/10.1007/s00213-018-5008-3

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