Skip to main content
Log in

Effects of blue light and caffeine on mood

  • Original Investigation
  • Published:
Psychopharmacology Aims and scope Submit manuscript

Abstract

Rationale

Both short wavelength (blue) light and caffeine have been studied for their mood enhancing effects on humans. The ability of blue light to increase alertness, mood and cognitive function via non-image forming neuropathways has been suggested as a non-pharmacological countermeasure for depression across a range of occupational settings.

Objectives

This experimental study compared blue light and caffeine and aimed to test the effects of blue light/placebo (BLU), white light/240-mg caffeine (CAF), blue light/240-mg caffeine (BCAF) and white light/placebo (PLA), on mood.

Methods

A randomised, controlled, crossover design study was used, in a convenience population of 20 healthy volunteers. The participants rated their mood on the Swedish Core Affect Scales (SCAS) prior to and after each experimental condition to assess the dimensions of valence and activation.

Results

There was a significant main effect of light (p = 0.009), and the combination of blue light and caffeine had clear positive effects on core effects (ES, ranging from 0.41 to 1.20) and global mood (ES, 0.61 ± 0.53).

Conclusions

The benefits of the combination of blue light and caffeine should be further investigated across a range of applications due to the observed effects on the dimensions of arousal, valence and pleasant activation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  • Beaven CM, Ekström JG (2013) A comparison of blue light and caffeine effects on cognitive function and alertness in humans. PLoS One 8:e76707

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Berson DM (2003) Strange vision: ganglion cells as circadian photoreceptors. Trends Neurosci 26:314–320

    Article  CAS  PubMed  Google Scholar 

  • Berson DM, Dunn FA, Takao M (2002) Phototransduction by retinal ganglion cells that set the circadian clock. Science 295:1070–1073

    Article  CAS  PubMed  Google Scholar 

  • Boutrel B, Koob GF (2004) What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications. Sleep 27:1181–1194

    PubMed  Google Scholar 

  • Brainard GC, Hanifin JP, Greeson JM, Byrne B, Glickman G, Gerner E et al (2001) Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor. J Neurosci 21:6405–6412

    CAS  PubMed  Google Scholar 

  • Broderick P, Benjamin AB (2004) Caffeine and psychiatric symptoms: a review. J Okla State Med Assoc 97:538–542

    PubMed  Google Scholar 

  • Cacioppo JT, Gardner WL, Berntson GG (1999) The affect system has parallel and integrative processing components: form follows function. J Pers Soc Psychol 76:839–855

    Google Scholar 

  • Cajochen C, Zeitzer JM, Czeisler CA, Dijk DJ (2000) Dose–response relationship for light intensity and ocular and electroencephalographic correlates of human alertness. Behav Brain Res 115:75–83

    Article  CAS  PubMed  Google Scholar 

  • Cajochen C, Frey S, Anders D, Späti J, Bues M, Pross A et al (2011) Evening exposure to a light-emitting diodes (LED)-backlit computer screen affects circadian physiology and cognitive performance. J Appl Physiol 110:1432–1438

    Article  PubMed  Google Scholar 

  • Chellappa SL, Steiner R, Blattner P, Oelhafen P, Götz T, Cajochen C (2011) Non-visual effects of light on melatonin, alertness and cognitive performance: can blue-enriched light keep us alert? PLoS One 26:e16429

    Article  Google Scholar 

  • Childs E, Wit H (2006) Subjective, behavioral, and physiological effects of acute caffeine in light, nondependent caffeine users. Psychopharmacology 185:514–523

    Article  CAS  PubMed  Google Scholar 

  • Czeisler CA, Shanahan TL, Klerman EB, Martens H, Brotman DJ, Emens JS et al (1995) Suppression of melatonin secretion in some blind patients by exposure to bright light. N Engl J Med 332:6–11

    Article  CAS  PubMed  Google Scholar 

  • Figueiro MG, Rea MS (2010) The effects of red and blue lights on circadian variations in cortisol, alpha amylase, and melatonin. Int J Endocrinol 829351

  • Fredholm BB, Bättig K, Holmén J, Nehlig A, Zvartau EE (1999) Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 51:83–133

    CAS  PubMed  Google Scholar 

  • Glickman G, Byrne B, Pineda C, Hauck WW, Brainard GC (2006) Light therapy for seasonal affective disorder with blue narrow-band light-emitting diodes (LEDs). Biol Psychiatry 59:502–507

    Article  PubMed  Google Scholar 

  • Golden RN, Gaynes BN, Ekstrom RD, Hamer RM, Jacobsen FM, Suppes T et al (2005) The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence. Am J Psychiatry 162:656–662

    Article  PubMed  Google Scholar 

  • Goldstein A, Warren R, Kaizer S (1965) Psychotropic effects of caffeine in man I. Individual differences in sensitivity to caffeine-induced wakefulness. J Pharmacol Exp Ther 149:156–159

    CAS  PubMed  Google Scholar 

  • Haskell CF, Kennedy DO, Wesnes KA, Scholey AB (2005) Cognitive and mood improvements of caffeine in habitual consumers and habitual non-consumers of caffeine. Psychopharmacology 179:813–825

    Article  CAS  PubMed  Google Scholar 

  • Hatori M, Panda S (2010) The emerging roles of melanopsin in behavioral adaptation to light. Trends Mol Med 16:435–446

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hattar S, Liao HW, Takao M, Berson DM, Yau KW (2002) Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science 295:1065–1070

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Heschong L, Wright RL, Okura S (2002) Daylighting impacts on human performance in school. J Illum Eng Soc N Am 101–114

  • Hopkins WG, Marshall SW, Batterham AM, Hanin J (2009) Progressive statistics for studies in sports medicine and exercise science. Med Sci Sports Exerc 41:3–12

    Article  PubMed  Google Scholar 

  • Iskra-Golec IM, Wazna A, Smith L (2012) Effects of blue-enriched light on the daily course of mood, sleepiness and light perception: a field experiment. Light Res Technol 44:506–513

    Article  Google Scholar 

  • Joarder AR, Price ADF (2013) Impact of daylight illumination on reducing patient length of stay in hospital after coronary artery bypass graft surgery. Light Res Technol 45:435–449

    Article  Google Scholar 

  • Kaplan GB, Greenblatt DJ, Ehrenberg BL, Goddard JE, Cotreau MM, Harmatz JS et al (1997) Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans. J Clin Pharmacol 37:693–703

    Article  CAS  PubMed  Google Scholar 

  • Lang PJ (1995) The emotion probe: studies of motivation and attention. Am Psychol 50:372–385

    Google Scholar 

  • Lara DR (2010) Caffeine, mental health, and psychiatric disorders. J Alzheimers Dis 20:239–248

    Google Scholar 

  • Lee TM, Chan CC, Paterson JG, Janzen HL, Blashko CA (1997) Spectral properties of phototherapy for seasonal affective disorder: a meta-analysis. Acta Psychiatr Scand 96:117–121

    Article  CAS  PubMed  Google Scholar 

  • Lieberman HR, Wurtman RJ, Emde GG, Roberts C, Coviella ILG (1987) The effects of low doses of caffeine on human performance and mood. Psychopharmacology 92:308–312

    Article  CAS  PubMed  Google Scholar 

  • Lieberman HR, Tharion WJ, Shukitt-Hale B, Speckman KL, Tulley R (2002) Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training. Sea-Air-Land. Psychopharmacology 164:250–261

    Article  CAS  PubMed  Google Scholar 

  • Lieverse R, Van Someren EJ, Nielen MM, Uitdehaag BM, Smit JH, Hoogendijk WJ (2011) Bright light treatment in elderly patients with nonseasonal major depressive disorder: a randomized placebo-controlled trial. Arch Gen Psychiatr 68:61–70

    Article  PubMed  Google Scholar 

  • Lockley SW, Brainard GC, Czeisler CA (2003) High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light. J Clin Endocrinol Metab 88:4502–4505

    Article  CAS  PubMed  Google Scholar 

  • Lucas M, Mirzaei F, Pan A, Okereke OI, Willett WC, O’Reilly EJ et al (2011) Coffee, caffeine, and risk of depression among women. Arch Intern Med 171:1571–1578

    Article  PubMed Central  PubMed  Google Scholar 

  • Meesters Y, Dekker V, Schlangen L, Bos E, Ruiter M (2011) Low-intensity blue-enriched white light (750 lux) and standard bright light (10 000 lux) are equally effective in treating SAD. A randomized controlled study. BMC Psychiatr 11:17

    Article  Google Scholar 

  • Mills PR, Tomkins SC, Schlangen LJM (2007) The effect of high correlated colour temperature office lighting on employee wellbeing and work performance. J Circadian Rhythm 5

  • Morin CM, Bootzin RR, Buysse DJ, Edinger JD, Espie CA, Lichstein KL (2006) Psychological and behavioral treatment of insomnia:update of the recent evidence (1998–2004). Sleep 29:1398–1414

    PubMed  Google Scholar 

  • Mott MS., Robinson DH., Walden A., Burnette J., Rutherford AS (2012) Illuminating the effects of dynamic lighting on student learning. SAGE Open

  • Nitschke JB, Heller W, Imig JC, McDonald RP, Miller GA (2001) Distinguishing dimensions of anxiety and depression. Cogn Ther Res 25:1–22

    Article  Google Scholar 

  • Perrin F, Peigneux P, Fuchs S, Verhaeghe S, Laureys S, Middleton B et al (2004) Nonvisual responses to light exposure in the human brain during the circadian night. Curr Biol 14:1842–1846

    Article  CAS  PubMed  Google Scholar 

  • Phelps EA (2006) Emotion and cognition: insights from studies of the human amygdala. Ann Rev Psychol 57:27–53

    Article  Google Scholar 

  • Phipps-Nelson J, Redman JR, Dijk DJ, Rajaratnam SM (2003) Daytime exposure to bright light, as compared to dim light, decreases sleepiness and improves psychomotor vigilance performance. Sleep 26:695–700

    PubMed  Google Scholar 

  • Rautkylä E, Puolakka M, Halonen L (2012) Alerting effects of daytime light exposure—a proposed link between light exposure and brain mechanisms. Light Res Technol 44:238–252

    Article  Google Scholar 

  • Reisenzein R (1994) Pleasure-arousal theory and the intensity of emotions. J Pers Soc Psychol 67:525–539

    Google Scholar 

  • Revell VL, Arendt J, Fogg LF, Skene DJ (2006) Alerting effects of light are sensitive to very short wavelengths. Neurosci Lett 399:96–100

    Article  CAS  PubMed  Google Scholar 

  • Rogers PJ (2007) Caffeine, mood and mental performance in everyday life. Nutr Bull 32:84–89

    Article  Google Scholar 

  • Rüger M, Gordijn MCM, Beersma DGM, de Vries B, Daan S (2006) Time-of-day-dependent effects of bright light exposure on human psychophysiology: comparison of daytime and nighttime exposure. American Journal of Physiology—Regulatory. Integr Comp Physiol 290:R1413–R1420

    Article  Google Scholar 

  • Ruusunen A, Lehto SM, Tolmunen T, Mursu J, Kaplan GA, Voutilainen S (2010) Coffee, tea and caffeine intake and the risk of severe depression in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Public Health Nutr 13:1215–1220

    Article  PubMed  Google Scholar 

  • Sicard BA, Perault MC, Enslen M, Chauffard F, Vandel B, Tachon P (1996) The effects of 600 mg of slow release caffeine on mood and alertness. Aviat Space Environ Med 67:859–862

    CAS  PubMed  Google Scholar 

  • Skinner TL., Jenkins DG., Leveritt MD., McGorm A., Bolam KA., Coombes JS. et al (2013) Factors influencing serum caffeine concentrations following caffeine ingestion. Journal of Science and Medicine in Sport

  • Smit HJ, Rogers PJ (2000) Effects of low doses of caffeine on cognitive performance, mood and thirst in low and higher caffeine consumers. Psychopharmacology 152:167–173

    Article  CAS  PubMed  Google Scholar 

  • Smith A (2009) Effects of caffeine in chewing gum on mood and attention. Hum Psychopharmacol: Clin Exp 24:239–247

    Article  CAS  Google Scholar 

  • Smith A, Sutherland D, Christopher G (2005) Effects of repeated doses of caffeine on mood and performance of alert and fatigued volunteers. J Psychopharmacol 19:620–626

    Article  CAS  PubMed  Google Scholar 

  • Vandewalle G, Balteau E, Phillips C, Degueldre C, Moreau V, Sterpenich V et al (2006) Daytime light exposure dynamically enhances brain responses. Curr Biol 16:1616–1621

    Article  CAS  PubMed  Google Scholar 

  • Vandewalle G, Gais S, Schabus M, Baleau E, Carrier J, Darsaud A et al (2007) Wavelength-dependent modulation of brain responses to a working memory test by daytime light exposure. Cereb Cortex 17:2788–2795

    Article  CAS  PubMed  Google Scholar 

  • Västfjäll D, Gärling T (2007) Validation of a Swedish short self‐report measure of core affect. Scand J Psychol 48:233–238

    Google Scholar 

  • Västfjäll D, Friman M, Gärling T, Kleiner M (2002) The measurement of core affect: a Swedish self‐report measure derived from the affect circumplex. Scand J Psychol 43:19–31

    Google Scholar 

  • Viola AU, James LM, Schlangen LJ, Dijk DJ (2008) Blue-enriched white light in the workplace improves self-reported alertness, performance and sleep quality. Scand J Work, Environ Health 34:297–306

    Article  Google Scholar 

  • Walch JM, Rabin BS, Day R, Williams JN, Choi K, Kang JD (2005) The effect of sunlight on postoperative analgesic medication use: a prospective study of patients undergoing spinal surgery. Psychosom Med 67:156–163

    Article  PubMed  Google Scholar 

  • Warburton DM, Bersellini E, Sweeney E (2001) An evaluation of a caffeinated taurine drink on mood, memory and information processing in healthy volunteers without caffeine abstinence. Psychopharmacology 158:322–328

    Article  CAS  PubMed  Google Scholar 

  • Winston AP, Hardwick E, Jaberi N (2005) Neuropsychiatric effects of caffeine. Adv Psychiatr Treat 11:432–439

    Article  Google Scholar 

  • Wood B, Rea MS, Plitnick B, Figueiro MG (2013) Light level and duration of exposure determine the impact of self-luminous tablets on melatonin suppression. Appl Ergon 44:237–240

    Article  PubMed  Google Scholar 

  • Wright KP Jr, Badia P, Myers B, Plenzler S (1997) Combination of bright light and caffeine as a countermeasure for impaired alertness and performance during extended sleep deprivation. J Sleep Res 6:26–35

    Article  PubMed  Google Scholar 

  • Wright KP Jr, Myers BL, Plenzler SC, Drake CL, Badia P (2000) Acute effects of bright light and caffeine on nighttime melatonin and temperature levels in women taking and not taking oral contraceptives. Brain Res 873:310–317

    Article  CAS  PubMed  Google Scholar 

  • Zaidi FH, Hull JT, Peirson SN, Wulff K, Aeschbach D, Gooley JJ et al (2007) Short-wavelength light sensitivity of circadian, pupillary, and visual awareness in humans lacking an outer retina. Curr Biol 17:2122–2128

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Johan G. Ekström.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ekström, J.G., Beaven, C.M. Effects of blue light and caffeine on mood. Psychopharmacology 231, 3677–3683 (2014). https://doi.org/10.1007/s00213-014-3503-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00213-014-3503-8

Keywords

Navigation