References
Blokland A, Lieben CKJ, van Oorsouw KIM, Deutz NEP (2001) A new method for lowering plasma tryptophan concentrations: no effect on affective behavior but impaired object memory in rats. Soc Neurosci Abstr 27:319-311
Blokland A, Lieben C, Deutz NEP (2002) Anxiogenic and depressive-like effects, but no cognitive deficits, after repeated moderate tryptophan depletion in rat. J Psychopharmacol 16:39-49
Briley M, Chopin P, Moret C (1990) Effect of serotonergic lesion on “anxious” behaviour measured in the elevated plus-maze test in the rat. Psychopharmacology 101:187-189
Brown CM, Fletcher PJ, Coscina DV (1998) Acute amino acid loads that deplete brain serotonin fail to alter behavior. Pharmacol Biochem Behav 59:115-121
Colado MI, Murray TK, Green AR (1993) 5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), pchloroamphetamine and fenfluramine administration and the effects of chlormethiazole and dizocilpine. Br J Pharmacol 108:583-589
File SE, Zangrossi H, Viana M, Graeff FG (1993) Trial 2 in the elevated plus-maze - a different form of fear. Psychopharmacology 111:491-494
Fone KCF, Beckett SRG, Topham IA, Swettenham J, Ball M, Maddocks L (2002) Long-term changes in social interaction and reward following repeated MDMA administration to adolescent rats without accompanying serotonergic neurotoxicity. Psychopharmacology 159:437-444
Gamma A, Frei E, Lehmann D, Pascual-Marqui RD, Hell D, Vollenweider FX (2000) Mood state and brain electric activity in Ecstasy users. Neuroreport 11:157-162
Griebel G (1995) 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. Pharmacol Ther 65:319-395
Gurtman CG, Morley KC, Li KM, Hunt GE, McGregor IS (2002) Increased anxiety in rats after 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy): association with serotonin depletion. Eur J Pharmacol (in press)
Hall FS, Devries AC, Fong GW, Huang S, Pert A (1999) Effects of 5,7-dihydroxytryptamine depletion of tissue serotonin levels on extracellular serotonin in the striatum assessed with in vivo microdialysis: relationship to behavior. Synapse 33:16-25
Hogg S (1996) A review of the validity and variability of the elevated plus-maze animal model of anxiety. Pharmacol Biochem Behav 54:21-30
Iversen SD (1984) 5-HT and anxiety. Neuropharmacology 23:1553-1560
McCann UD, Eligulashvili V, Mertl M, Murphy DL, Ricaurte GA (1999) Altered neuroendocrine and behavioral responses to mchlorophenylpiperazine in 3,4-methylene methamphetamine (MDMA) users. Psychopharmacology 147:56-65
Mechan AO, Moran PM, Elliott JM, Young AMJ, Joseph MH, Green AR (2002a) A comparison between Dark Agouti and Sprague-Dawley rats in their behaviour on the elevated plusmaze, open-field apparatus and activity meters, and their response to diazepam. Psychopharmacology 159:188-195
Mechan AO, Moran PM, Elliott JM, Young AMJ, Joseph MH, Green AR (2002b) A study of the effects of a single neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) on the subsequent long-term behaviour of rats in the plus maze and open field. Psychopharmacology 159:167-175
Morgan MJ (1998) Recreational use of ecstasy (MDMA) is associated with increased impulsivity. Neuropsychopharmacology 19:252-264
Morley KC, Gallate JE, Hunt GE, Mallet PE, McGregor IS (2001) Increased anxiety and impaired memory in rats 3 months after administration of 3,4-methylenedioxymethamphetamine (Ecstasy). Eur J Pharmacol 433:91-99
Parrott AC (2001) Human psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research. Hum Psychopharmacol 16:557-577
Parrott AC, Sisk E, Turner JD (2000) Psychobiological problems in heavy ecstasy (MDMA) polydrug users. Drug Alcohol Depend 60:105-110
Soubrie P (1986) Reconciling the role of central serotonin neurons in human and animal behaviour. Behav Brain Sci 9:319-364
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Green, A.R., McGregor, I.S. On the anxiogenic and anxiolytic nature of long-term cerebral 5-HT depletion following MDMA. Psychopharmacology 162, 448–450 (2002). https://doi.org/10.1007/s00213-002-1158-3
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DOI: https://doi.org/10.1007/s00213-002-1158-3