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A mechanistic review of the pharmacological potential of narirutin: a dietary flavonoid

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Abstract

Flavanones, a type of polyphenol, are found in substantial amounts in citrus fruits. When high- or moderate-dose orange juice consumption occurs, flavanones make up a significant portion of the total polyphenols in plasma. Disaccharide derivative narirutin, mainly dihydroxy flavanone, is found in citrus fruits. The substantial chemotherapeutic potential of narirutin has been amply demonstrated by numerous experimental studies. Consequently, the purpose of this study is to compile the research that has already been done showing narirutin to be a promising anticancer drug, with its mechanism of action being documented in treatment plans for various cancer forms. Narirutin functions in a variety of cancer cells by regulating several pathways that include cell cycle arrest, apoptosis, antiangiogenic, antimetastatic, and DNA repair. Narirutin has been shown to modify many molecular targets linked to the development of cancer, including drug transporters, cell cycle mediators, transcription factors, reactive oxygen species, reactive nitrogen species, and inflammatory cytokines. Taken together, these reviews offer important new information about narirutin’s potential as a potent and promising drug candidate for use in medicines, functional foods, dietary supplements, nutraceuticals, and other products targeted at improving the treatment of cancer.

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Funding

The authors are thankful to the Deanship of Scientific Research, King Khalid University, Abha, Saudi Arabia, for financially supporting this work through the small Research Group Project under Grant no. R.G.P.1/226/44.

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Authors and Affiliations

  1. University Centre for Research and Development, University Institute of Biotechnology, Chandigarh University, Gharuan, Mohali, Punjab, India

    Pratibha Pandey & Seema Ramniwas

  2. Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, India

    Fahad Khan

  3. Department of Biology, College of Science, University of Hail, Hail, Saudi Arabia

    Mohd Saeed

  4. Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi Arabia

    Irfan Ahmad

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P.P., F.K. and S.R. wrote the main manuscript text. P.P., F.K., M.S., and I.A. prepared the figures, tables and helped in review and editing the revised manuscript. All authors reviewed the manuscript. The authors confirm that no paper mill and artificial intelligence was used.

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Pandey, P., Khan, F., Ramniwas, S. et al. A mechanistic review of the pharmacological potential of narirutin: a dietary flavonoid. Naunyn-Schmiedeberg's Arch Pharmacol (2024). https://doi.org/10.1007/s00210-024-03022-w

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