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The protective effect of chemical and natural compounds against vincristine-induced peripheral neuropathy (VIPN)

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Abstract

Vincristine, an alkaloid extracted from Catharanthus rosea, is a class of chemotherapy drugs that act by altering the function of the microtubules and by inhibiting mitosis. Despite its widespread application, a major adverse effect of vincristine that limits treatment duration is the occurrence of peripheral neuropathy (PN). PN presents with several symptoms including numbness, painful sensation, tingling, and muscle weakness. Vincristine-induced PN involves impaired calcium homeostasis, an increase of reactive oxygen species (ROS), and the upregulation of tumor necrosis factor-alpha (TNF-α), and interleukin 1 beta (IL-1β) expression. Several potential approaches to attenuate the vincristine-induced PN including the concomitant administration of chemicals with vincristine have been reported. These chemicals have a variety of pharmaceutical properties including anti-inflammation, antioxidant, and inhibition of calcium channels and calcineurin signaling pathways and increased expression of nerve growth factor (NGF). This review summarized several of these compounds and the mechanisms of action that could lead to effective options in improving vincristine-induced peripheral neuropathy (VIPN).

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Acknowledgements

The authors are thankful to Mashhad University of Medical Sciences for financial support.

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Authors and Affiliations

  1. Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Mitra Khodaei, Soghra Mehri, Soroush Rashid Pour, Fatemeh Yarmohammadi & Gholamreza Karimi

  2. Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Soghra Mehri & Gholamreza Karimi

  3. Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

    Shakiba Mahdavi

  4. Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran

    Fatemeh Yarmohammadi

  5. Center for Environmental Occupational Risk Analysis and Management, College of Public Health, University of South Florida, Tampa, FL, USA

    A. Wallace Hayes

  6. Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA

    A. Wallace Hayes

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  1. Mitra Khodaei
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  2. Soghra Mehri
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  3. Soroush Rashid Pour
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  4. Shakiba Mahdavi
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  5. Fatemeh Yarmohammadi
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  6. A. Wallace Hayes
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  7. Gholamreza Karimi
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Contributions

GhK conceived and designed research. GhK and RR revised and edited the manuscript. FY wrote the manuscript. The authors declare that all data were generated in-house and that no paper mill was used. The authors read and approved the final version of the manuscript.

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Correspondence to Soghra Mehri or Gholamreza Karimi.

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Khodaei, M., Mehri, S., Pour, S.R. et al. The protective effect of chemical and natural compounds against vincristine-induced peripheral neuropathy (VIPN). Naunyn-Schmiedeberg's Arch Pharmacol 395, 907–919 (2022). https://doi.org/10.1007/s00210-022-02254-y

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  • DOI: https://doi.org/10.1007/s00210-022-02254-y

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