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Every year, the editors of the Archives of Toxicology review their most cited publications from the previous 2 years (Table 1). Currently, our most cited paper is a review article by Beyersmann and Hartwig (2008) on carcinogenic metal compounds. The authors, in this article, comprehensively describe the key mechanisms responsible for metal carcinogenicity, namely inhibition of DNA repair, deregulation of signal transduction and oxidative stress induction. Incidentally, oxidative stress control is one of the cutting-edge topics frequently published in our journal. Therefore, the editors invited Jose M. Matés and colleagues to present a review article (2008) on how reactive oxygen species can modify intracellular signalling pathways. Their contribution is the second most cited paper in our journal. Number three on our citation ranking list is the article by Olavi Pelkonen and colleagues (2008) focusing on the induction and inhibition of cytochrome P450 enzymes, including a comprehensive overview of the most relevant compounds. The most cited original article is a systematic study on tissue distribution and toxicity of titanium dioxide nanoparticles (Fabian et al. 2008). The take home messages of our most cited articles have been summarized in Table 1.
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Bolt, H.M., Hengstler, J.G. Most cited articles: metal toxicity, oxidative stress control and induction as well as inhibition of cytochrome P450 enzymes. Arch Toxicol 84, 903–905 (2010). https://doi.org/10.1007/s00204-010-0624-7
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DOI: https://doi.org/10.1007/s00204-010-0624-7