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Combination of texture analysis and bone mineral density improves the prediction of fracture load in human femurs

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Abstract

Summary

Twenty-one excised femurs were studied using (1) a high-resolution digital X-ray device to estimate three textural parameters, (2) dual-energy X-ray absorptiometry (DXA) to measure bone mineral density (BMD), and (3) mechanical tests to failure. Textural parameters significantly correlated with BMD (p < 0.05) and bone strength (p < 0.05). Combining texture parameters and BMD significantly improved the fracture load prediction from adjusted r 2 = 0.74 to adjusted r 2 = 0.82 (p < 0.05).

Introduction

The purpose of this study is to determine if the combination of bone texture parameters using a new high-resolution X-ray device and BMD measurement by DXA provided a better prediction of femoral failure load than BMD evaluation alone.

Methods

The proximal ends of 21 excised femurs were studied using (1) a high-resolution digital X-ray device (BMA™, D3A Medical Systems) to estimate three textural parameters: fractal parameter Hmean, co-occurrence, and run-length matrices, (2) DXA to measure BMD, and (3) mechanical tests to failure in a side-impact configuration. Regions of interest in the femoral neck, intertrochanteric region, and greater trochanter were selected for DXA and bone texture analysis. Every specimen was scanned twice with repositioning before mechanical testing to assess reproducibility using intraclass correlation coefficient (ICC) with 95% confidence interval. The prediction of femoral failure load was evaluated using multiple regression analysis.

Results

Thirteen femoral neck and 8 intertrochanteric fractures were observed with a mean failure load of 2,612 N (SD, 1,382 N). Fractal parameter Hmean, co-occurrence, and run-length matrices each significantly correlated with site-matched BMD (p < 0.05) and bone strength (p < 0.05). The ICC of the textural parameters varied between 0.65 and 0.90. Combining bone texture parameters and BMD significantly improved the fracture load prediction from adjusted r 2 = 0.74 to adjusted r 2 = 0.82 (p < 0.05).

Conclusion

In these excised femurs, the combination of bone texture parameters with BMD demonstrated a better performance in the failure load prediction than that of BMD alone.

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Authors and Affiliations

  1. Department of Radiology, Hôpital Sainte Marguerite, 270 Boulevard de Sainte Marguerite, 13009, Marseille, France

    T. Le Corroller, D. Guenoun & P. Champsaur

  2. Institut des Sciences du Mouvement, UMR CNRS 6233, Université de la Méditerranée, CP910, Avenue de Luminy, 13288, Marseille Cedex 09, France

    T. Le Corroller, J. Halgrin, M. Pithioux, P. Chabrand & P. Champsaur

Authors
  1. T. Le Corroller
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  2. J. Halgrin
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  3. M. Pithioux
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  4. D. Guenoun
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  5. P. Chabrand
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  6. P. Champsaur
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Correspondence to T. Le Corroller.

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Le Corroller, T., Halgrin, J., Pithioux, M. et al. Combination of texture analysis and bone mineral density improves the prediction of fracture load in human femurs. Osteoporos Int 23, 163–169 (2012). https://doi.org/10.1007/s00198-011-1703-1

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  • DOI: https://doi.org/10.1007/s00198-011-1703-1

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