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Duloxetine 1 year on: the long-term outcome of a cohort of women prescribed duloxetine

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Abstract

This aim of this study was to determine the long-term persistence with duloxetine in a cohort of women treated for stress incontinence and any alternative treatments undertaken. Two hundred twenty-eight women prescribed duloxetine were initially reviewed after 4 weeks of treatment. Women continuing therapy were reassessed at 4 and 6 months and 1 year with a review of all treatments after 1 year. At each visit, they were asked about persistence with duloxetine, reasons for discontinuation and any alternative treatments. Seventy-one (31%) women continued beyond 4 weeks of treatment, and twenty-six (12%) were taking duloxetine 4 months later, 23 (10%) at 6 months and 21 (9%) at 1 year. One year later, 187 (82%) women had a tension-free vaginal tape operation (TVT). The majority of women discontinued because of side effects (56%) or lack of efficacy (33%). Few women persevere with duloxetine beyond 4 months. One year later, the majority of women had a TVT.

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Conflict of interest statement

Jonathan Duckett has received funding to attend conferences from the makers of duloxetine.

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, Urogynaecology Unit, Medway Maritime Hospital, Windmill Road, Gillingham, Kent, ME7 5NY, UK

    Maria Vella, Jonathan Duckett & Maya Basu

Authors
  1. Maria Vella
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  2. Jonathan Duckett
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  3. Maya Basu
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Correspondence to Jonathan Duckett.

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Vella, M., Duckett, J. & Basu, M. Duloxetine 1 year on: the long-term outcome of a cohort of women prescribed duloxetine. Int Urogynecol J 19, 961–964 (2008). https://doi.org/10.1007/s00192-008-0564-4

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  • DOI: https://doi.org/10.1007/s00192-008-0564-4

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