Abstract
Sub-Saharan Africa (SSA) is the region with the highest projected rates of increase in type 2 diabetes (129% by 2045), which will exacerbate the already high prevalence of type 2 diabetes complications and comorbidities in SSA. In addition, SSA is grappling with poverty-related health problems and infectious diseases and is also undergoing the most rapid rates of urbanisation globally. These socioenvironmental and lifestyle factors may interact with genetic factors to alter the pathophysiological sequence leading to type 2 diabetes in sub-Saharan African populations. Indeed, current evidence from SSA and the diaspora suggests that the pathophysiology of type 2 diabetes in Black Africans is different from that in their European counterparts. Studies from the diaspora suggest that insulin clearance is the primary defect underlying the development of type 2 diabetes. We propose that, among Black Africans from SSA, hyperinsulinaemia due to a combination of both increased insulin secretion and reduced hepatic insulin clearance is the primary defect, which promotes obesity and insulin resistance, exacerbating the hyperinsulinaemia and eventually leading to beta cell failure and type 2 diabetes. Nonetheless, the current understanding of the pathogenesis of type 2 diabetes and the clinical guidelines for preventing and managing the disease are largely based on studies including participants of predominately White European ancestry. In this review, we summarise the existing knowledge base and data from the only non-pharmacological intervention that explores the pathophysiology of type 2 diabetes in SSA. We also highlight factors that may influence the pathogenesis of type 2 diabetes in SSA, such as social determinants, infectious diseases and genetic and epigenetic influences.
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Introduction
Global estimates for the prevalence of type 2 diabetes are as high as 9.3%, affecting 463 million people [1]. While the prevalence of type 2 diabetes is lowest in the sub-Saharan Africa (SSA) region (4.7%), this varies by country, with the highest number of people with type 2 diabetes residing in more affluent countries [1]. SSA is also the region with the highest burden of infectious diseases, which also impacts on type 2 diabetes risk [2]. Notably, SSA is projected to have the greatest rates of increase in type 2 diabetes (129% by 2045) compared with other IDF regions [1]. This will exacerbate the already high prevalence of type 2 diabetes complications and comorbidities in SSA [3], placing additional strain on the already overburdened healthcare systems.
Despite the increasing projected rates of type 2 diabetes and other non-communicable diseases, SSA is still grappling with poverty-related health problems and is also undergoing the most rapid rates of urbanisation globally. These socioenvironmental and lifestyle factors may interact with genetic factors to alter the pathophysiological sequence leading to type 2 diabetes in sub-Saharan African populations. Indeed, current evidence suggests that the pathophysiology of type 2 diabetes in Black Africans is different from that in their European counterparts [4]. Nonetheless, the current understanding of the pathogenesis of type 2 diabetes and the clinical guidelines for preventing and managing the disease are largely based on studies including participants of predominately White European ancestry. This review aims to consolidate the current knowledge base on the mechanisms underlying type 2 diabetes risk in Black African populations living in SSA. As the pathophysiology of type 2 diabetes in diasporic Africans has been extensively reviewed [5,6,7,8,9], and due to the high degree of genetic admixture and different environmental exposures [10], we will focus primarily on studies including sub-Saharan African populations, which are under-represented in the literature. The review will highlight commonalities and differences between sub-Saharan African and diasporic populations, and importantly identify unique characteristics that influence the pathogenesis of type 2 diabetes in SSA, such as social determinants, infectious diseases and genetic/epigenetic factors.
Known mechanisms relating to the pathophysiology of type 2 diabetes in sub-Saharan Africans
While it is well accepted that insulin resistance and beta cell dysfunction contribute to the pathogenesis of type 2 diabetes (Fig. 1a), there is still debate regarding the pathogenic sequence of events leading to type 2 diabetes [11]. The conventional paradigm is that insulin resistance is the primary defect, resulting in compensatory hyperinsulinaemia and leading eventually to beta cell exhaustion and type 2 diabetes [12]. However, there is increasing support for the theory that hyperinsulinaemia may be the distinct first event in the pathogenesis of type 2 diabetes [11], with the primary hyperinsulinaemic factors being posited as hypersecretion of insulin from the beta cells [11, 13] and/or reduced hepatic insulin clearance [14].
Hyperinsulinaemia as the primary event in the pathophysiology of type 2 diabetes
Studies from SSA and the diaspora have consistently shown that the most characteristic feature in the pathophysiology of type 2 diabetes in Black African populations is the presentation of hyperinsulinaemia (Fig. 1b), as reviewed previously [7, 9]. Compared with White Europeans, Black Africans with normal glucose tolerance (NGT), impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) present with hyperinsulinaemia [9], characterised by higher insulin secretion and lower insulin clearance, which is largely independent of differences in adiposity and insulin sensitivity [9, 15, 16]. This phenotype is observed in indigenous and diasporic Black African adults and children [17], suggesting that this trait is highly conserved [16]. However, it is still not clear if this hyperinsulinaemia is due to exaggerated beta cell function or low hepatic insulin clearance. While most studies to date have relied on cross-sectional designs, the prevailing evidence from West Africa, the UK and the USA has shown that low hepatic insulin clearance is the main driver of hyperinsulinaemia in adults [16, 18, 19], with insulin clearance being proposed as the primary defect underlying the development of type 2 diabetes [8, 14]. This is in direct contrast to our recent evidence indicating that elevated insulin secretion was more closely associated with hyperinsulinaemia than low hepatic insulin clearance in Black South African women with obesity [20]. In preliminary analyses of a small (n=112) prospective cohort of middle-aged Black South African women with NGT, we showed that insulin secretion, and not insulin clearance, independently predicted incident dysglycaemia 1.5 years later (Mtintsilana and Goedecke et al, unpublished; Fig. 2). The few other studies from SSA have relied on a cross-sectional design, with some contradictory findings in relation to these putative pathophysiological links. Amoah et al [21] showed that, despite similarities in insulin sensitivity, healthy NGT first-degree relatives of Ghanaians with type 2 diabetes had higher insulin and C-peptide responses to both oral and intravenous glucose than healthy NGT control groups without a family history of type 2 diabetes. These findings suggest that hyperinsulinaemia may be a primary factor in the aetiology of type 2 diabetes in Black Africans. The presentation of type 2 diabetes in this population was characterised by severe beta cell dysfunction, and to a lesser extent a decrease in insulin sensitivity [21], which is consistent with the findings from the Africans in America study, which includes Black Africans born in SSA and currently living in the USA [22]. The study showed that beta cell failure rather than insulin resistance was the main aetiological factor in 62% of Africans with IGT [23]. This corresponds to the findings from a cross-sectional study among Tanzanian adults, which showed that beta cell dysfunction and insulin resistance were associated with a higher risk of IGT and type 2 diabetes, and that beta cell dysfunction was the most important contributor to type 2 diabetes [23]. In contrast, results of the Research on Obesity and Diabetes among African Migrants (RODAM) study showed that insulin resistance (HOMA-IR) and not beta cell dysfunction accounted for geographical differences in IFG between rural and urban/migrant Ghanaians without type 2 diabetes [24]. However, this was a cross-sectional study with fasting glucose as the only marker of dysglycaemia, and it is well known that dysglycaemia in Black African populations overwhelmingly presents as elevated 2 h glucose and not as elevated fasting glucose [25]. Glucose tolerance is not only dependent on insulin-mediated glucose uptake, but also depends on the ability of glucose to mediate its own uptake (glucose effectiveness), which accounts for ~45–65% of glucose disposal [26]. However, glucose effectiveness does not differ by ethnicity [15] and is not a characteristic of type 2 diabetes in Black Africans [21]. We propose that, in SSA, hyperinsulinaemia due to a combination of both increased insulin secretion and reduced hepatic insulin clearance may be the primary aetiological factor, which promotes obesity [17] and insulin resistance, exacerbating the hyperinsulinaemia and eventually leading to beta cell failure and type 2 diabetes.
The role of adipose tissue in the pathogenesis of insulin resistance and type 2 diabetes
Regardless of the sequence of events, studies in SSA and the diaspora have consistently shown that Black Africans have lower insulin sensitivity than their White European counterparts [5, 6, 8, 15, 27]. To date, most of the work in understanding the high prevalence of insulin resistance in Black Africans from SSA has focused on adipose tissue. This was largely driven by the paradoxical but consistent finding that, despite lower whole-body insulin sensitivity, Black Africans have less visceral adipose tissue (VAT) and more abdominal and gluteo-femoral subcutaneous adipose tissue (SAT) than their BMI-matched White European counterparts [28, 29], which is consistent with the pattern seen in diasporic Africans [5, 17].
Accordingly, the veracity of the traditional paradigm of the pathogenesis of type 2 diabetes, with obesity and adipose tissue expansion being the initial manifestation of insulin resistance [12] (Fig. 1a), was tested (Fig. 1b). We found that, compared with normal-weight women, the expression of adipogenic and lipogenic genes was reduced in the gluteal depot to a greater extent in Black South African women with obesity than in White South African women with obesity [30], which corresponded to Black South African women having a greater proportion of large adipocytes in this depot. Further, the gluteal SAT of Black South African women with obesity exhibited higher expression of genes relating to hypoxia, fibrosis and inflammation than that of their White counterparts [31, 32]. These findings suggest that, despite a more ‘favourable’ body fat distribution, a lower capacity to store fat in the gluteo-femoral depot with increasing obesity is associated with reduced insulin sensitivity in Black South African women [30, 31]. Indeed, gluteal SAT of Black South African women with obesity exhibited increased mitochondrial respiration capacity and hydrogen peroxide production than abdominal SAT, suggestive of cellular stress related to an over flux of NEFA into the mitochondria [33]. The higher oxidative stress was associated with lower insulin sensitivity [33]. Surprisingly, the higher SAT inflammatory profile of Black South African women was not associated with their lower insulin sensitivity, as in White South African women [32]. These findings, together with another study including Black South African women with obesity showing regional differences in the transcriptome signatures between abdominal and gluteal SAT [34], suggest that there are differences in developmental processes regulating the expandability of distinct adipose tissue depots.
The role of ectopic fat in the pathogenesis of type 2 diabetes
Despite evidence of low gluteal SAT expandability in Black South African women with obesity, there is consistent evidence from Africa and the diaspora showing lower ectopic fat deposition than in White Europeans [4, 8, 35]. While the evidence relating to intramyocellular and pancreatic fat is limited [20], there is robust evidence showing that Black Africans have lower hepatic fat accumulation than White Europeans [35, 36], which parallels their lower levels of VAT [28, 29]. Lower hepatic fat content in Black South African women with obesity corresponded to higher hepatic insulin sensitivity compared with their White counterparts [36], as well as lower estimated rates of de novo lipogenesis [37], consistent with findings in African Americans [38]. Accordingly, circulating triacylglycerol levels are lower in Black Africans and are not associated with reduced insulin sensitivity [39]. This suggests that, unlike in White European populations, de novo lipogenesis and hepatic fat accumulation are not early features of insulin resistance and type 2 diabetes in Black African populations. This is supported by our recent cross-sectional study in Black South African women with obesity in which we showed that higher VAT levels, and not pancreatic or hepatic fat, were associated with lower first-phase insulin secretion and higher hepatic insulin clearance [20]. Indeed, with increasing age and adiposity, Black African women have a greater relative propensity to accumulate VAT compared with abdominal or gluteo-femoral SAT [40]. Notably, both baseline and the change in VAT predicted incident type 2 diabetes in middle-aged Black South African women 13 years later [40]. This raises the question as to whether Black Africans are more sensitive to the effects of ectopic fat accumulation than their White European counterparts [36]. A recent study in Ghanaians, using fatty liver index as a proxy for liver fat, showed that the fatty liver index increases with increasing urbanisation and is associated with prevalent type 2 diabetes [41], which supports the latter hypothesis.
Sex differences in the pathophysiology of type 2 diabetes
There is a sexual dimorphism in type 2 diabetes risk in Africans, which is clearly illustrated by a similar type 2 diabetes prevalence in sub-Saharan African men and women [1] despite vast differences in obesity prevalence (e.g. 41% vs 11% in South African women and men, respectively) [42]. The few studies including sex comparisons indicate that Black African women exhibit greater hyperinsulinaemia than Black African men [22, 43]. However, we argue that Black South African men are at a higher risk for type 2 diabetes than Black South African women for the following reasons: (1) when adjusting for differences in body fat, men have lower insulin sensitivity, insulin secretion and beta cell function, while insulin clearance did not differ by sex; (2) men have a less ‘favourable’ body fat distribution, with more VAT and less abdominal and gluteo-femoral SAT; (3) there is a stronger relationship between total and central adiposity and type 2 diabetes risk in men; (4) men have a lower ‘protective’ effect of leg fat mass on beta cell function than women [43]. These disparities may be driven by the obvious effects of sex hormones, but there are no studies to our knowledge that have explored these effects in SSA. In terms of sex differences in lifestyle factors, studies in SSA have shown that men are more likely to smoke, consume alcohol and participate in more moderate-to-vigorous physical activity (MVPA) than women [44, 45], which may confound these associations. Indeed, we recently showed that MVPA was associated with lower type 2 diabetes risk in men, whereas light physical activity was associated with reduced type 2 diabetes risk in women [46]. When interrogating the relevance of dietary intake, we showed that, although nutrient patterns did not differ between men and women, the strength of the association between the animal-driven nutrient pattern and BMI was greater in men than in women. In contrast, the plant-driven pattern, characterised by the intake of refined carbohydrates, was associated with increases in abdominal SAT in women but not in men [47]. We postulated that hyperinsulinaemia observed in Black African women compared with men may drive this relationship. However, to our knowledge, there are no longitudinal studies exploring the pathogenesis of type 2 diabetes in sub-Saharan African men. Further, most studies exploring the pathophysiology of type 2 diabetes in sub-Saharan African populations are focused on women or include more women than men, which may bias our interpretation of the results. Longitudinal and intervention studies are thus key to illuminating the full aetiology and pathogenic sequence of type 2 diabetes in both Black African men and women.
Lifestyle interventions to inform our understanding of the pathophysiology of type 2 diabetes
Lifestyle interventions are used as non-pharmacological models to understand the pathophysiology of type 2 diabetes. Specifically, these models have focused on improving insulin sensitivity and/or beta cell function via exercise training or dietary-induced weight loss [48, 49]. This research approach has primarily focused on populations of White European descent, with limited data on Africans and the diaspora [50, 51] and only one study in SSA [52]. The results of the lifestyle intervention studies in African Americans have been previously reviewed [17, 53] and it was concluded that African Americans were resistant to weight change compared with their White American counterparts. The study in SSA was an RCT designed to examine the mechanisms underlying the changes in insulin sensitivity and secretion in response to a 12 week exercise (combined aerobic and resistance) intervention in young Black South African women with obesity [52]. The study aimed to identify causal pathways underlying the high prevalence of insulin resistance and risk for type 2 diabetes, while targeting specific areas for therapeutic intervention (Fig. 3).
Studies that have shown an improvement in insulin sensitivity after exercise training have mainly reported a reduction in insulin response [54, 55], with exercise intensity and volume influencing the degree of change [55]. The 12 week exercise intervention in Black South African women showed that the improvement in insulin sensitivity was not matched by a change in insulin response, characterised by insulin secretion or clearance [49]. This suggests that hyperinsulinaemia may not be a compensatory response to insulin resistance in Black Africans and the maintenance of hyperinsulinaemia may have attenuated exercise-induced lipolysis and weight loss. Indeed, we observed only a ~1 kg weight loss in response to the 12 week moderate/high-intensity exercise training intervention [49]. We also did not observe any changes in liver, muscle or pancreatic fat, suggesting that the improvement in insulin sensitivity in response to exercise training may be independent of ectopic lipids [49]. Further, the improvement in insulin sensitivity was not related to the other traditional mechanisms underlying insulin resistance, including body fat distribution, adipose tissue and skeletal muscle function, and systemic inflammation [33, 49, 56, 57]. These findings provide further evidence that the pathogenesis of type 2 diabetes in Black Africans may be different from that in Europeans [4].
We propose a model of the pathogenesis of type 2 diabetes in Black Africans from SSA (Fig. 4) that needs to be tested in longitudinal and intervention studies. We suggest that interventions designed specifically to reduce hyperinsulinaemia and induce greater reductions in adiposity may be more appropriate to investigate the pathogenesis of type 2 diabetes in Black Africans. Very low energy (very low calorie diets [VLCDs]) and low-carbohydrate diets are associated with reduced insulin secretion [48, 58] and may be more appropriate for populations with hyperinsulinaemia. Indeed, a study from the USA showed that African American women lost more weight in response to a lower-carbohydrate diet than a lower-fat diet, whereas there was no difference in weight loss between the two diets in European women [59]. The only study to use a VLCD to reverse type 2 diabetes in a population of African descent was performed in Barbados. This study reported less weight loss than similar studies in Europe [60]. Nonetheless, the study found that 10 kg weight loss was associated with remission in 60% of participants at 8 weeks and in 38% of participants at 8 months; however, it did not explore the putative underlying mechanisms. The attenuated weight loss in these diasporic populations may reflect the consequences of hyperinsulinaemia in African populations [17] and/or differences in sociocultural factors, which may influence adherence to interventions. To date, there are no studies in SSA that have assessed the effects of dietary interventions on the pathophysiology of type 2 diabetes, and future research is warranted.
Factors that may influence the pathogenesis of type 2 diabetes in sub-Saharan Africans
Social determinants of type 2 diabetes
An analysis of the pathogenesis underlying type 2 diabetes risk would be incomplete without addressing the effects of syndemics and the social determinants of health. To understand the phenotype in Black Africans, it is key to understand the interplay between biology, disease clusters and lifestyle factors, as well as how these factors impact known mechanisms relating to the development of type 2 diabetes. Within SSA, rapid demographic, sociocultural and economic transitions are driving increases in risk factors for type 2 diabetes [61]. Indeed, the characteristics of people with type 2 diabetes differ between those living in urban settings and those living in rural settings [62, 63], with those in rural settings characterised by having a lower socioeconomic status (SES), younger age of onset, higher prevalence of reported childhood undernutrition and lower prevalence of traditional risk factors such as obesity [63]. In direct contrast to findings from Europe, level of education, which is the most stable and sensitive marker of SES, is positively associated with type 2 diabetes in SSA [62]. This relationship is likely mediated by the effects of early life experiences and/or effects of other lifestyle factors that impact type 2 diabetes risk, such as dietary intake and physical activity. While countries within SSA are still in the early stages of the nutrition transition [64], low dietary diversity and the high reliance on processed carbohydrate-rich staple diets [65, 66] in the context of hyperinsulinaemia may drive the increases in obesity, particularly in women [47].
Although the prevalence of obesity is increasing in SSA, undernutrition remains a problem, especially in young children and in adults with severe infections. Notably, childhood SES and early life nutritional status are associated with increased risk for type 2 diabetes in adults [67,68,69], with this amplified by subsequent catch-up growth or adult obesity [68, 69]. Exposure to chronic undernutrition is associated with low insulin production in both children [70] and adult men [71]. This corresponds with the presentation of the predominant form of atypical diabetes in SSA, identified as malnutrition-related diabetes mellitus [72]. This phenotype is highly prevalent (~30% of patients) and presents in people living in low socioeconomic circumstances and who have a low BMI and relative beta cell impairment [72, 73]. This presence of different subtypes of diabetes in SSA needs to be explored further in large phenotyping and genotyping studies. These studies need to consider traits most prevalent in SSA, for example, sickle cell disease, which is an inherited disorder characterised by structural changes in haemoglobin. While people with sickle cell trait (representing ~25% of the sub-Saharan African population) do not have symptoms of sickle cell disease, they are at higher risk of beta cell dysfunction, with the risk for type 2 diabetes exacerbated by anti-retroviral therapy (ART) [74].
Infectious diseases
Fifty per cent of global deaths and disability-adjusted life-years due to infectious diseases are in SSA [75], with SSA having the greatest burden of HIV/AIDS (67.5% of all 37.9 million people living with HIV [PLWH]). In SSA, young women and adolescent girls accounted for 63% of all new HIV infections in 2020, of whom Black South African women/girls are disproportionately affected [76]. Since the successful roll-out of ART in SSA, there has been an associated rise in life expectancy and non-communicable diseases such as obesity and type 2 diabetes in PLWH, ensuring the collision of these disease clusters [77]. Indeed, protease inhibitors impair beta cell function by increasing apoptosis and oxidative stress, thereby decreasing insulin secretion [78]. While data from Africa are limited and there is a need for prospective longitudinal studies, a recent meta-analysis of studies of African populations showed no association between the prevalence of type 2 diabetes and HIV infection or ART [79]. Regardless, the occurrence of type 2 diabetes seen with first-generation ART has been partly resolved with newer drugs, but there may be residual effects of long-term exposure to multiple first-generation ARTs [80]. The ADVANCE study in South Africa has shown a ‘return to health’ weight gain in ART-naive men and women initiating the new first-line therapy in Africa (dolutegravir) compared with those initiating efavirenz [81]. However, this has raised concerns about the detrimental effects of weight gain and risk for metabolic abnormalities in an obesogenic environment. Notably, PLWH in Africa often present with other viral co-infections such as tuberculosis and hepatitis C, resulting in chronic low-grade inflammation that can further exacerbate the risk of developing type 2 diabetes. In addition to factors such as chronic inflammation and immune activation, PLWH in Africa commonly experience sociodemographic disparity and chronic malnutrition compared with HIV-uninfected people [71]. These factors combined may explain the higher prevalence of type 2 diabetes in PLWH.
In addition to HIV, other viruses may trigger type 2 diabetes development. Results from a meta-analysis have shown that hepatitis C infection, which has one of the highest reported seroprevalence rates in West Africa (~2.8%) [82], is associated with a ~1.7-fold increased risk for type 2 diabetes compared with non-infected control groups [83]. Additionally, there is evidence to suggest that Human herpesvirus 8 infection is strongly linked to type 2 diabetes and, in particular, ketosis-prone type 2 diabetes [84], which frequently occurs in individuals of African origin and is characterised by an acute and reversible deficiency in insulin secretion. In SSA, Human herpesvirus 8 infection is not related to a decrease in insulin sensitivity in patients with diabetes [85], but rather is associated with low insulin secretion [86], which is supported by an early in vitro study showing that Human herpesvirus 8 can directly infect human pancreatic beta cells [84]. In contrast to these viruses, Schistosoma and geohelminth infections lower the risk of type 2 diabetes [87], with a recent study from Tanzania showing that Schistosoma infection was associated with higher beta cell function [88]. However, this was offset by HIV co-infection, as Schistosoma and geohelminth infections were associated with reduced beta cell function among PLWH and ART-naive individuals [88].
Genetic and epigenetic factors
Genome-wide association studies (GWAS) have identified over 400 risk loci for type 2 diabetes. However, most of these studies have been conducted in European populations, and studies conducted in African populations have predominately included African American populations [89]. Although these studies are informative, African Americans are admixed (~20% European ancestry) and their environmental exposures also differ from those in people living in SSA. Africans harbour a far greater amount of genetic diversity and recently about 3 million variants from this population group were reported to be missing from publicly available databases [10]. Africans display lower linkage disequilibrium and shorter haplotype blocks than other populations. These characteristics help with fine mapping of GWAS signals and identification of target genes, which are not only required to gain mechanistic insights, but may also inform therapeutic targets [89].
Only recently, through the Africa America Diabetes Mellitus (AADM) study [90], the Durban Diabetes Study (DDS) [91] and the Human Heredity and Health in Africa (H3Africa) Initiative [92], have GWAS of type 2 diabetes in sub-Saharan African populations been undertaken. A meta-analysis of 4347 sub-Saharan Africans showed that the variant most significantly associated with type 2 diabetes mapped to a locus near TCF7L2, replicating findings in other ethnic groups [93]. Fine mapping of TCF7L2 revealed both an African-specific signal (rs17746147) and a signal shared with Europeans (rs7903146). The authors identified a novel African-specific association signal at AGMO (rs73284431) and 21 loci with shared causal variants in African and non-African populations [93]. Similarly, in a second GWAS using the AADM cohort, Adeyemo et al [94] showed transferability of 32 established type 2 diabetes loci, but also identified a novel locus for type 2 diabetes, namely ZRANB3, which has been shown to play a critical role in the production and maintenance of beta cells [94]. These findings highlight the importance of performing further adequately powered GWAS in SSA to identify novel risk loci to improve our understanding of the genetic architecture of type 2 diabetes in Africa. There are currently significant limitations to our understanding of the genetic underpinnings of certain traits, such as hepatic insulin clearance and body fat distribution, which appear to be specific and highly conserved in African populations. The increase of GWAS in SSA will enable the development of African-specific polygenic risk scores [95], which may refine type 2 diabetes risk prediction and provide greater understanding of the pathogenesis of type 2 diabetes in Africans.
Environmental factors also play a role in the aetiology of type 2 diabetes. Gene–environment interactions need to be considered, particularly in SSA where the genetic architecture, as well as environmental exposures, differs from those of European populations. The effects of the environment on type 2 diabetes risk may be mediated through epigenetic factors, such as DNA methylation, histone acetylation and microRNAs (miRNAs). In the first epigenome-wide association study (EWAS) in SSA, the team from the RODAM study identified four differentially methylated loci that were strongly and consistently associated with type 2 diabetes. Of these, three had been reported previously in other populations, but one differentially methylated locus was unique to the Ghanaian sample [96]. This again highlights the unique genetic architecture of Africans and the need for further EWAS to validate and extend these findings. More recently, a small study in South African women has shown that DNA methylation differs by ethnicity, obesity and adipose tissue depot [97]. Pheiffer et al profiled global and insulin receptor promotor DNA methylation in abdominal and gluteal SAT and revealed that global DNA methylation in gluteal SAT was associated with insulin resistance and systemic inflammation in Black South African women and not in White South African women [97]. These studies add to the body of work suggesting a specific role of gluteal SAT in type 2 diabetes risk in Black African women. As DNA methylation is reversible, identification of risk DNA methylation patterns may provide unique opportunities for intervention strategies.
Conclusions
This review synthesises the evidence from SSA and shows that the pathogenesis of type 2 diabetes in Black Africans differs from the traditional model based on studies including participants of European ancestry and is mostly like that reported in diasporic Africans. We propose a model that highlights hyperinsulinaemia as the preeminent factor in the pathogenesis of type 2 diabetes in Black Africans (Fig. 4). However, there is a need for longitudinal and intervention studies to gain a complete understanding of the pathogenesis of type 2 diabetes in Black African men and women. Dietary interventions that reduce hyperinsulinaemia and obesity are recommended to gain insights into the mechanistic underpinnings of type 2 diabetes in this population.
Abbreviations
- AADM:
-
Africa America Diabetes Mellitus
- ART:
-
Anti-retroviral therapy
- EWAS:
-
Epigenome-wide association study
- GWAS:
-
Genome-wide association studies
- IFG:
-
Impaired fasting glucose
- IGT:
-
Impaired glucose tolerance
- MVPA:
-
Moderate-to-vigorous physical activity
- NGT:
-
Normal glucose tolerance
- PLWH:
-
People living with HIV
- RODAM:
-
Research on Obesity and Diabetes among African Migrants
- SAT:
-
Subcutaneous adipose tissue
- SES:
-
Socioeconomic status
- SSA:
-
Sub-Saharan Africa
- VAT:
-
Visceral adipose tissue
- VLCD:
-
Very low calorie diet
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Goedecke, J.H., Mendham, A.E. Pathophysiology of type 2 diabetes in sub-Saharan Africans. Diabetologia 65, 1967–1980 (2022). https://doi.org/10.1007/s00125-022-05795-2
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DOI: https://doi.org/10.1007/s00125-022-05795-2