Zusammenfassung
Die radikale Zystektomie (RC) stellt den Goldstandard in der Therapie des muskelinvasiven Urothelkarzinoms der Harnblase dar. Verbesserungen der Operationstechnik und der perioperativen Betreuung haben sie zu einem Eingriff gemacht, der auch in einem alternden Patientenkollektiv gut und sicher durchführbar ist. In den letzten Jahren hat sich die Klassifikation von Komplikationen nach Clavien-Dindo in der Literatur zu urologischen Krankheitsbildern etabliert. Der Charlson-Comorbidity-Index ohne Alterskorrektur kann in der Behandlungsplanung vor RC zur Abschätzung des Mortalitäts- und Komplikationsrisikos herangezogen werden
Abstract
Radical cystectomy (RC) represents the gold standard in the treatment of muscle invasive urothelial cancer of the bladder. Due to improvements in operation techniques and perioperative care it has become a good and safe procedure even in elderly patients. In recent years the Clavien-Dindo classification has been frequently used for complication assessment in urological research. The Charlson comorbidity index without age correction can be used in treatment planning for RC to identify patients at risk.
Literatur
Hautmann RE, Abol-Enein H, Hafez K et al (2007) Urinary diversion. Urology 69(1 Suppl):17–49
Stein JP, Lieskovsky G, Cote R et al (2001) Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients. J Clin Oncol 19(3):666–675
Donat SM, Siegrist T, Cronin A et al (2010) Radical cystectomy in octogenarians – does morbidity outweigh the potential survival benefits? J Urol 183(6):2171–2177
Novara G, De Marco V, Aragona M et al (2009) Complications and mortality after radical cystectomy for bladder transitional cell cancer. J Urol 182(3):914–921
Shabsigh A, Korets R, Vora KC et al (2009) Defining early morbidity of radical cystectomy for patients with bladder cancer using a standardized reporting methodology. Eur Urol 55(1):164–174
Studer UE, Burkhard FC, Schumacher M et al (2006) Twenty years experience with an ileal orthotopic low pressure bladder substitute – lessons to be learned. J Urol 176(1):161–166
Nielsen ME, Shariat SF, Karakiewicz PI et al (2007) Advanced age is associated with poorer bladder cancer-specific survival in patients treated with radical cystectomy. Eur Urol 51(3):699–708
Hollenbeck BK, Miller DC, Taub D et al (2004) Aggressive treatment for bladder cancer is associated with improved overall survival among patients 80 years old or older. Urology 64(2):292–297
Wehrberger C, Berger I, Marszalek M et al (2010) Bladder preservation in octogenarians with invasive bladder cancer. Urology 75:370–375
Liguori G, Trombetta C, Pomara G et al (2007) Major invasive surgery for urologic cancer in octogenarians with comorbid medical conditions Eur Urol 51(6):1600–1605
Martin RC 2nd, Brennan MF, Jaques DP (2002) Quality of complication reporting in the surgical literature. Ann Surg 235(6):803–813
Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6,336 patients and results of a survey. Ann Surg 240:205–213
Löppenberg B, Noldus J, Holz A, Palisaar RJ (2010) Reporting complications after open radical retropubic prostatectomy using the Martin criteria. J Urol 184(3):944–948
Charlson ME, Pompei P, Ales K, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis 40:373–383
Hall WH, Ramachandran R, Narayan S et al (2004) An electronic application for rapidly calculating Charlson comorbidity score. BMC Cancer 20(4):94
Saklad, Meyer MD (1941) Grading of patients for surgical procedures. Anesthesiology 2(3):281–284
Wittekind C GF, Hutter R et al (2007) TNM Atlas: illustrated guide to the TNM/pTNM classification of malignant tumors. Springer, Berlin Heidelberg New York
Lee CT, Dunn RL, Chen BT (2004) Impact of body mass index on radical cystectomy. J Urol 172(4 Pt 1):1281–1285
Mayr R, May M, Martini T et al (2012) Predictive capacity of four comorbidity indices estimating perioperative mortality after radical cystectomy for urothelial carcinoma of the bladder. BJU Int (Epub ahead of print), doi: 10.1111/j.1464-410X.2012.10938.x
Morgan TM et al (2011) Predicting the probability of 90-day survival of elderly patients with bladder cancer treated with radical cystectomy. J Urol 186(3):829–834
Koppie TM, Serio AM, Vickers AJ et al (2008) Age-adjusted Charlson comorbidity score is associated with treatment decisions and clinical outcomes for patients undergoing radical cystectomy for bladder cancer. Cancer 112(11):2384–2392
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Roghmann, F., Noldus, J., von Bodman, C. et al. Die Zystektomie im Alter. Urologe 51, 1386–1392 (2012). https://doi.org/10.1007/s00120-012-2930-6
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DOI: https://doi.org/10.1007/s00120-012-2930-6