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Endobronchialer Ultraschall beim Bronchialkarzinom

Endobronchial ultrasound in lung cancer

  • Maligne Thoraxtumoren: CT und MRT
  • Published:
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Zusammenfassung

Das Staging des Bronchialkarzinoms hat für die Therapieentscheidung eine zentrale Rolle. Radiologische Verfahren sowie die konventionelle Endoskopie haben Limitationen, speziell wenn es um die Frage des Lymphknotenstagings und der Frühkarzinome geht. Hierzu wurde an unserer Klinik der endobronchiale Ultraschall (EBUS) entwickelt. EBUS stellt eine Erweiterung der diagnostischen Möglichkeiten in der Bronchoskopie dar. Die Methode kann problemlos und für den Patienten komplikationslos angewendet werden. Die diagnostische Aussage der Bronchoskopie kann verbessert werden.

Abstract

Conventional imaging procedures proved to be insufficient for staging of lung cancer especially with respect of N-stage, infiltration of mediastinal structures and early lung cancer. As also the view of the endoscopist is restricted we developed the new method of endobronchial ultrasonography (EBUS) as adjunct to conventional bronchoscopy. The initial technical problems were solved by development of a balloon catheter for application of miniaturized 20 MHz probes.

EBUS is a new technology that can be easily applied and is well tolerated. It improves the results of bronchoscopy in addition to conventional diagnostic procedures. Further developments will be made in future to improve the application of ultrasound in chest medicine.

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Literatur

  1. Bülzebruck H, Bopp R, Drings P, Bauer E, Krysa S, Probst G, van Kaick G, Müller KM, Vogt-Moykopf I (1992) New aspects in the staging of lung cancer. Cancer 70(5):1102–1110

    CAS  PubMed  Google Scholar 

  2. Layer G, van Kaick G (1990) Staging des nichtkleinzelligen Bronchialkarzinoms mit CT und MRT. Radiologe 30:155–163

    CAS  PubMed  Google Scholar 

  3. Bonomo L, Ciccotosto C, Guidotto A et al. (1996) Lung cancer staging: the role of computer tomography and magnetic resonance imaging. Eur J Radiol 23:35–45

    Article  CAS  PubMed  Google Scholar 

  4. Kleinau H, Liebeskind U, Zaiaic M, Schlag PM (1993) Endoluminal and intraoperative ultrasound. Onkologie 16:435–432

    Google Scholar 

  5. Herth F, Becker HD (2000) Endobronchial ultrasound of the airways and the mediastinum. Monaldi Arch Chest Dis 55(1):36–45

    CAS  PubMed  Google Scholar 

  6. Herth F, Becker HD (2001) Endobronchial ultrasound (EBUS)—assessment of a new diagnostic tool in bronchoscopy. Onkologie 24:151–154

    Article  CAS  PubMed  Google Scholar 

  7. Shirakawa T, Tanaka F, Becker HD (2001) Layer structure of central airway viewed using endobronchial ultrasonography (EBUS). In: Yoshimura H, Kida A, Arai T, Niimi S, Kaneko M, Kitahara S (eds) Bronchology and bronchoesophagology: state of the art. Elsevier, Amsterdam London New York, pp 921–923

  8. Hürther T, Hanrath P (1992) Endobronchial sonography: feasibility and preliminary results. Thorax 47:565–567

    PubMed  Google Scholar 

  9. Naruke T, Suemasu K, Ishikawa S (1978) Lymph node mapping and curability at various levels of metastasis in rescted lung cancer. J Thorac Cardiovasc Surg 76:832–839

    CAS  PubMed  Google Scholar 

  10. Lam S, Kennedy T, Unger M et al. (1998) Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy. Chest 113:696–702

    CAS  PubMed  Google Scholar 

  11. Akaogi E, Ogawa I, Mitsui K et al. (1994) Endoscopic criteria of early squamous cell carcinoma of the bronchus. Cancer 74:3113–3117

    CAS  PubMed  Google Scholar 

  12. Sutedja G, Schramel FMNH, Smit HJF, Postmus PE (1996) Bronchoscopic electrocautery has a curative potential for small intraluminal lung tumors. Eur Resp J 9:374

    Google Scholar 

  13. Herth F, Becker HD (2001) New aspects in early detection and local staging of early lung cancer. Cancer 34(3):7–11

    Article  Google Scholar 

  14. Herth F, Becker HD, LoCicero J III, Ernst A (2003) Endobronchial ultrasound is useful for further classification of suspicious lesions detected by autofluorescense-bronchoscopy. J Bronchol 10:249–252

    Article  Google Scholar 

  15. Miyazu Y, Miyazawa T, Kurimoto N, Iwamoto Y, Kanoh K, Kohno N (2002) Endobronchial ultrasonography in the assessment of centrally located early-stage lung cancer before photodynamic therapy. Am J Respir Crit Care Med 165(6):832–837

    PubMed  Google Scholar 

  16. Herth FJ, Ernst A, Schulz M, Becker HD (2003) Endobronchial ultrasound reliably differentiates between airway infiltration and compression by tumor. Chest 123:458–462

    Article  PubMed  Google Scholar 

  17. Takemoto Y, Kawahara M, Ogawara M et al. (2000) Ultrasound-guided flexible bronchoscopy for the diagnosis of tumor invasion to the bronchial wall and mediastinum. J Bronchol 7(2):127–132

    Google Scholar 

  18. Kurimoto N, Murayama M, Yoshioka S, Nishisaka T, Inai K, Dohi K (1999) Assessment of usefulness of endobronchial ultrasonography in determination of depth of tracheobronchial tumor invasion. Chest 115(6):1500–1506

    Article  CAS  PubMed  Google Scholar 

  19. Gasparini S, Zuccatosta L, DeNictolis M (2000) Transbronchial needle aspiration of mediastinal lesions. Monaldi Arch Chest Dis 55(1):29–32

    CAS  PubMed  Google Scholar 

  20. Herth FJ, Becker HD, Ernst A (2003) Ultrasound-guided transbronchial needle aspiration: an experience in 242 patients. Chest 123:604–607

    Article  PubMed  Google Scholar 

  21. Herth F, Hecker E, Hoffmann H, Becker HD (2002) Endobronchial ultrasound for local tumour and lymph node staging in patients with centrally growing lung cancer. Ultraschall Med 23(4):251–255

    Article  CAS  PubMed  Google Scholar 

  22. Herth FJF, Ernst A, Becker HD (2004) Conventional vs. endobronchial ultrasound guided transbronchial needle aspiration (TBNA)—a randomized trial. Chest 125:322–325

    Google Scholar 

  23. Falcone F, Fois F, Grosso D (2003) Endobronchial ultrasound. Respiration 70(2):179–194

    Article  PubMed  Google Scholar 

  24. Herth F, Ernst A, Becker HD (2002) Endobronchial ultrasound (EBUS) guided transbronchial lung biopsy (TBBX) in solitary pulmonary nodules and peripheral lesions. Eur Respir J 20:972–975

    Article  CAS  PubMed  Google Scholar 

  25. Kurimoto N, Murayama M, Yoshioka S, Nishisaka T (2002) Analysis of the internal structure of peripheral pulmonary lesions using endobronchial ultrasonography. Chest 122(6):1887–1894

    Article  PubMed  Google Scholar 

  26. Turner JF (2002) Endobronchial ultrasound and peripheral pulmonary lesions: localization and histopathologic correlates using a miniature probe and the flexible bronchoscope. Chest 122(6):1874–1875

    Article  CAS  PubMed  Google Scholar 

  27. Becker HD, Herth F (2002) Computer assisted analysis of endosonographic images in solitary pulmnonary nodules (SPN). Eur Res J 20(8):462

    Google Scholar 

  28. Herth F, Ernst A, Becker HD (2002) Endobronchial ultrasound in therapeutic bronchoscopy. Eur Respir J 20:118–121

    Article  CAS  PubMed  Google Scholar 

  29. Metha AC, Kavuru MS, Meeker DP et al. (1989) Transbronchial needle aspiration for histology specimens. Chest 96:1268–1272

    PubMed  Google Scholar 

  30. Herth FJF, Ernst A, Becker HD (2002) Initial EBUS guided TBNA is the most cost-effective means of lymph node staging—a German experience trial. Chest 122(4):104

    Article  Google Scholar 

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Authors and Affiliations

  1. Abteilung Innere Medizin—Pneumologie, Thoraxklinik am Universitätsklinikum Heidelberg, Heidelberg

    F. J. F. Herth, H. D. Becker & R. Eberhardt

  2. Abteilung Innere Medizin—Pneumologie, Thoraxklinik am Universitätsklinikum Heidelberg, Amalienstr. 5, 69126 , Heidelberg

    F. J. F. Herth

Authors
  1. F. J. F. Herth
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  2. H. D. Becker
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  3. R. Eberhardt
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Correspondence to F. J. F. Herth.

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Herth, F.J.F., Becker, H.D. & Eberhardt, R. Endobronchialer Ultraschall beim Bronchialkarzinom. Radiologe 44, 457–464 (2004). https://doi.org/10.1007/s00117-004-1045-5

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  • DOI: https://doi.org/10.1007/s00117-004-1045-5

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