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„ConnectToBrain“

Synergy-Projekt zur Closed-loop-Stimulationstherapie von Netzwerkerkrankungen des Gehirns

“ConnectToBrain”

Synergy project for therapeutic closed-loop stimulation of brain network disorders

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Zusammenfassung

Therapeutische nichtinvasive transkranielle Hirnstimulation zeigt mit bisherigen Behandlungsprotokollen nur moderate Effektstärken und eine hohe interindividuelle Variabilität mit vielen Nonrespondern. Ein derzeit intensiv diskutierter Ansatz zur Lösung dieser Probleme ist eine individualisierte Closed-loop-Stimulation. ConnectToBrain ist ein vom Europäischen Forschungsrat gefördertes Synergy-Projekt zur Entwicklung einer nichtinvasiven therapeutischen Closed-loop-Stimulation von Netzwerkerkrankungen des Gehirns. Es besteht aus drei Säulen: (1) Entwicklung einer fast den gesamten zerebralen Kortex abdeckenden Multikanalspule zur transkraniellen Magnetstimulation (mTMS), mit der die Lokalisation, Richtung, Intensität und das Timing induzierter elektrischer Felder im Gehirn hochpräzise elektronisch gesteuert werden können; (2) Entwicklung der Echtzeitanalyse von Aktivität und Konnektivität in Hirnnetzwerken mittels Elektroenzephalographie (EEG) zur räumlichen und zeitlichen Steuerung der mTMS (hirnzustandsabhängige Stimulation) und adaptive Optimierung des Behandlungseffektes mit Ansätzen des maschinellen Lernens (Closed-loop-Stimulation); (3) Translation dieser Neurotechnologie in physiologische und klinische Studien.

Abstract

Therapeutic non-invasive transcranial brain stimulation with previous treatment protocols showed at best moderate effect sizes and large interindividual variability with a substantial proportion of non-responders. A currently intensively discussed approach to address these problems is individualized closed-loop stimulation. ConnectToBrain is a synergy project funded by the European Research Council to develop noninvasive closed-loop therapeutic stimulation of network disorders of the human brain.

It consists of three main pillars: (1) development of a multichannel transcranial magnetic stimulation (mTMS) coil array that covers nearly all of the cerebral cortex and enables highly precise electronic control of location, direction, intensity and timing of the induced electrical fields, (2) development of real-time analysis of activity and connectivity in brain networks using electroencephalography (EEG) for instantaneous spatial and temporal control of stimulation (brain state-dependent, closed-loop stimulation) and adaptive optimization of treatment effects by machine learning and (3) translation of these neurotechnological innovations into physiological and clinical studies.

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Authors and Affiliations

  1. Abteilung Neurologie mit Schwerpunkt neurovaskuläre Erkrankungen und Neuroonkologie, Hertie-Institut für Klinische Hirnforschung, Eberhard-Karls-Universität Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Deutschland

    Ulf Ziemann

  2. Institute for Advanced Biomedical Technologies, „Gabriele D’Annunzio“ University of Chieti-Pescara, Chieti, Italien

    Gian-Luca Romani

  3. Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, P.O. Box 12200, FI-00076, AALTO, Finnland

    Risto J. Ilmoniemi

Authors
  1. Ulf Ziemann
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  2. Gian-Luca Romani
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  3. Risto J. Ilmoniemi
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Corresponding author

Correspondence to Ulf Ziemann.

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Interessenkonflikt

U. Ziemann erhielt Honorare für Beraterleistungen von Biogen Idec GmbH, Bayer GmbH, Bristol Myers Squibb GmbH, Pfizer GmbH, CorTec GmbH, Medtronic GmbH, und Forschungsförderungen von Biogen Idec GmbH, Servier, Janssen Pharmaceuticals NV, sämtlich unabhängig von dem hier beschriebenen Forschungsprojekt. R.J. Ilmoniemi ist Erfinder auf Patentanträgen zu TMS- und mTMS-Technologie. Er ist Berater und Aktionär von Nexstim Plc. Er hat Honorare von Nexstim, MEGIN Ltd., und Brainsway Ltd. erhalten, die unabhängig von diesem Forschungsprojekt sind. G.-L. Romani hat keine Interessenskonflikte angegeben.

Sämtliche hier zitierten von den Autoren durchgeführten humanphysiologischen Studien wurden von den zuständigen Ethikkommissionen genehmigt und das informierte Einverständnis der Versuchsteilnehmer wurde vor Studieneinschluss eingeholt. Tierexperimentelle Untersuchungen wurden nicht durchgeführt.

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Ziemann, U., Romani, GL. & Ilmoniemi, R.J. „ConnectToBrain“. Nervenarzt 90, 804–808 (2019). https://doi.org/10.1007/s00115-019-0747-x

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  • DOI: https://doi.org/10.1007/s00115-019-0747-x

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