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Wechselwirkungen zwischen Depression und Schlaganfall

Pathophysiologische Mechanismen

Correlation of depression with stroke

Pathophysiological mechanisms

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Zusammenfassung

Der zerebrale Insult stellt eine der häufigsten Todesursachen weltweit dar. Die Inzidenz wird voraussichtlich in den nächsten Jahrzehnten drastisch ansteigen. Zur Prävention ist daher die genaue Kenntnis der Risikofaktoren und pathophysiologischen Mechanismen dringend notwendig. Inzwischen bestehen deutliche Hinweise, dass Schlaganfall und Depressionen sich gegenseitig beeinflussende Krankheitsentitäten sind, wie sich dies auch im Konzept der so genannten „post-stroke depression“ zeigt. Darüber hinaus wird postuliert, dass die Depression einen unabhängigen Risikofaktor für das Auftreten späterer Schlaganfälle darstellt. Von den Mechanismen, über die beide Erkrankungen in Wechselwirkung stehen, ist jedoch noch zu wenig bekannt. Diese Arbeit stellt verschiedene pathophysiologische Mechanismen dar, die sowohl zu einer Erhöhung des Risikos zerebraler Erkrankungen führen, als auch unter dem Einfluss depressiver Erkrankungen pathologisch verändert sein können und so Kandidaten für ein Bindeglied zwischen Schlaganfall und Depression sein könnten.

Summary

Stroke is the third leading cause of death, just after heart disease and cancer. Its incidence will probably increase dramatically in the coming decades. For prevention it is urgently necessary to gain fundamental knowledge about the risk factors and pathophysiological mechanisms. It is now widely accepted that depression and stroke are correlated with each other. There is little knowledge, however, about the links that might connect both diseases. This review discusses different mechanisms that lead to an increased stroke risk and can be influenced by depression as well thus possibly linking depression and stroke.

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  1. Abteilung für Psychiatrie und Psychotherapie, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050, Berlin, Deutschland

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Neu, P. Wechselwirkungen zwischen Depression und Schlaganfall. Nervenarzt 80, 772–780 (2009). https://doi.org/10.1007/s00115-009-2720-6

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