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Biochemische Knochenresorptionsmarker in der Heilungsphase osteoporotischer Frakturen

Biochemical bone resorption markers during the healing of osteoporotic fractures

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Zusammenfassung

Hintergrund

Diese Studie untersucht den Verlauf und die klinische Relevanz biochemischer Resorptionsmarker während der Frakturheilung bei Osteoporose.

Patienten und Methoden

Bei 44 Patientinnen mit distaler Radiusfraktur und 29 Patientinnen ohne Fraktur wurden die Blut- und Urinkonzentrationen von Pyridinolin (PYD), Desoxypyridinolin (DPD), N-Telopeptiden (NTx) und Bone-Sialoprotein (BSP) am Unfalltag und im Verlauf erfasst. Alle postmenopausalen Patientinnen wurden einer Knochendichtemessung unterzogen. Das Gesamtkollektiv wurde entsprechend in prämenopausal, postmenopausal osteoporotisch und postmenopausal nichtosteoporotisch eingeteilt.

Ergebnisse

Zwischen den Gruppen zeigten sich signifikante Unterschiede in den Ausgangswerten von PYD, DPD und NTx. Den weiteren relativen Verlauf beeinflusste vor allem die Art der jeweils eingeleiteten Therapie.

Schlussfolgerung

Knochenresorptionsmarker können diagnostisch Hinweise auf eine Osteoporose geben und eignen sich sehr gut als Verlaufsparameter bei der Frakturheilung.

Abstract

Background

This study investigated the progression and clinical relevance of biochemical resorption marker values during fracture healing in osteoporosis.

Patients and methods

In 44 patients with distal radius fractures and 29 patients without fractures, the blood and urine concentrations of pyridinoline (PYD), deoxypyridinoline (DPD), N-telopeptides (NTx), and bone sialoprotein (BSP) were recorded on the day of trauma as well as during further progression. All postmenopausal patients underwent bone density measurement. Accordingly, patients were divided into premenopausal, postmenopausal osteoporotic, and postmenopausal nonosteoporotic groups.

Results

Between the groups, PYD, DPD, and NTx showed significant differences in their initial values. However, their further relative progression was primarily affected by the chosen therapy.

Conclusion

Bone resorption markers can diagnostically point to osteoporosis and are significant parameters in fracture healing.

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Authors and Affiliations

  1. Klinik und Poliklinik für Unfallchirurgie, Universitätsklinikum Gießen–Marburg GmbH, Rudolf-Buchheim-Str. 7, 35385, Gießen, Deutschland

    C. Heiß, L.M. Hoesel, M. Pausch, S.A. Meißner, U. Horas, O. Kilian & R. Schnettler

  2. Tierärztliche Fakultät, Ludwig-Maximilians-Universität München, Oberschleißheim, Deutschland

    U. Wehr & W.A. Rambeck

Authors
  1. C. Heiß
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  2. L.M. Hoesel
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  3. M. Pausch
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  4. S.A. Meißner
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  5. U. Horas
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  6. O. Kilian
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  7. U. Wehr
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  8. W.A. Rambeck
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  9. R. Schnettler
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Corresponding author

Correspondence to C. Heiß.

Additional information

Diese Arbeit wurde im November 2003 auf der Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie (DGU) in Berlin mit dem 1. Posterpreis ausgezeichnet.

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Heiß, C., Hoesel, L., Pausch, M. et al. Biochemische Knochenresorptionsmarker in der Heilungsphase osteoporotischer Frakturen. Unfallchirurg 111, 695–702 (2008). https://doi.org/10.1007/s00113-008-1465-1

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