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Mechanistic study of optic atrophy 1 in ischemia-reperfusion disease

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Abstract

Mitochondria consist of the inner mitochondrial membrane and the outer mitochondrial membrane, which maintain mitochondrial homeostasis through continuous fission and fusion to ensure a healthy mitochondrial network and thus regulate normal cellular function, namely mitochondrial dynamics. The imbalance between mitochondrial fusion and fission results in abnormal mitochondrial structure and eventually mitochondrial dysfunction, which is involved in the pathological process of ischemia-reperfusion injury (IRI). Optic atrophy 1 (OPA1) is a key protein that regulates mitochondrial inner membrane fusion and ensures normal mitochondrial function by balancing mitochondrial dynamics, participating in various processes such as mitochondrial fusion, oxidative stress, and apoptosis. Ischemia-induced changes in mitochondrial dynamics may be a key factor in limiting the recanalization time window and exacerbating reperfusion injury, and the mechanisms of these changes deserve further attention. Therefore, targeting OPA1-related mitochondrial fusions, thereby balancing mitochondrial dynamics and improving mitochondrial dysfunction, is a promising therapeutic strategy for ischemia-reperfusion diseases. This review will elaborate on the structure and function of OPA1 and the role of OPA1 in IRI to provide promising therapeutic targets for the treatment of ischemia-reperfusion diseases.

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Acknowledgements

We thank all individuals who participated in or helped with this research.

Funding

This work was supported by the National Natural Science Foundation of China (Nos. 81704188) and the Natural Science Research Program of the Hubei Provincial Education Department (No.D20202006).

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Authors and Affiliations

  1. College of Acupuncture, Moxibustion and Orthopedics, Hubei University of Chinese Medicine, Wuhan, 430065, China

    Ying Yuan & Xiao-ming Zhang

  2. Sub-health institute Hubei university of Chinese Medicine, Wuhan, 430065, China

    Xiao-ming Zhang

  3. Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion Wuhan, Wuhan, 430065, China

    Xiao-ming Zhang

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  1. Ying Yuan
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Yuan, Y., Zhang, Xm. Mechanistic study of optic atrophy 1 in ischemia-reperfusion disease. J Mol Med 101, 1–8 (2023). https://doi.org/10.1007/s00109-022-02271-7

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