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Lymphogranuloma venereum

Eine alte Krankheit in neuem Kleid

Lymphogranuloma venereum

An old disease in a new dress

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Zusammenfassung

Lymphogranuloma venereum ist eine sexuell übertragene Erkrankung verursacht durch Chlamydia trachomatis der Serotypen L1, L2 und L3. Die klassische Manifestation ist eine schmerzhafte inguinale Lymphadenopathie, welche ohne Behandlung zu schwerwiegenden Komplikationen führt. Daneben wird seit einigen Jahren gehäuft eine ulzerierende Proktitis beschrieben, speziell bei Männern, die Sex mit Männern haben. Da die klinischen Beschwerden unspezifisch sind, muss bei Proktitis aktiv nach Chlamydia trachomatis gesucht werden. Die Diagnostik des Lymphogranuloma venereum erfolgt heute hauptsächlich mit molekularen Testverfahren. Zur Therapie wird Tetracyclin über 3 Wochen empfohlen. Die Erkrankung wird anhand von 5 aktuellen klinischen Fallbeispielen dargestellt.

Abstract

Lymphogranuloma venereum is a sexually transmitted disease caused by Chlamydia trachomatis, serotypes L1, L2 and L3. The classical clinical manifestation is a painful inguinal lymphadenopathy, resulting without treatment in severe complications. Over the last years, however, the emergence of massive ulcerative proctitis has been observed, especially in men who have sex with men. Because the clinical symptoms are unspecific, Chlamydia trachomatis should actively be looked for. Reliable and rapid molecular tests have now been established to diagnose lymphogranuloma venereum. The therapeutic recommendation is tetracyclin for 3 weeks. We present 5 cases to illustrate this disease.

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Danksagung

Wir danken Herrn Alexander Rufle vom Institut für Pathologie des Universitätsspitals Basel für die DNA-Isolierung der paraffineingebetteten Proben und Herrn Prof. Dr. Thomas Friedrich vom Labor Viollier Basel für das Überlassen von klinischen Proben.

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Der korrespondierende Autor erklärt, dass kein Interessenkonflikt besteht.

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Authors and Affiliations

  1. Klinik für Infektiologie & Spitalhygiene, Universitätsspital Basel, Basel, Schweiz

    M. de Roche & U. Flückiger

  2. Klinik für Gastroenterologie, Universitätsspital Basel, Basel, Schweiz

    M. Sawatzki & L. Degen

  3. Dermatologische Klinik, Universitätsspital Basel, Basel, Schweiz

    P. Itin

  4. Klinische Mikrobiologie, Universitätsspital Basel, Petersgraben 4, 4031, Basel, Schweiz

    R. Frei &  D. Goldenberger

Authors
  1. M. de Roche
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  2. M. Sawatzki
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  3. L. Degen
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  4. P. Itin
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  5. U. Flückiger
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  6. R. Frei
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  7. D. Goldenberger
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Corresponding author

Correspondence to D. Goldenberger.

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Anmerkung

Ein Teil der hier vorgestellten Daten wurde am 20th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) vom 10. bis 13. April 2010 als Poster (Nr. 668) präsentiert.

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de Roche, M., Sawatzki, M., Degen, L. et al. Lymphogranuloma venereum. Internist 52, 584–589 (2011). https://doi.org/10.1007/s00108-010-2686-2

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  • DOI: https://doi.org/10.1007/s00108-010-2686-2

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