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Tumormikromilieu des Melanoms – Einfluss moderner Therapien

Melanoma microenvironment—impact of modern therapies

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Zusammenfassung

Hintergrund

Trotz beachtlicher Erfolge moderner Melanomtherapien beim fortgeschrittenen Melanom verstirbt ein beachtlicher Anteil der Patienten an seinem metastasierten Leiden.

Ziel der Arbeit

Der Beitrag gibt einen Überblick über die Rolle des Tumormikromilieus des Melanoms unter besonderer Berücksichtigung zugelassener Systemtherapien und neuer Therapieansätze.

Methoden

Es erfolgen die Sichtung und Diskussion aktueller klinischer Forschung und Grundlagenforschung zum Einfluss des Mikromilieus auf Progression und Therapieregime beim fortgeschrittenen Melanom.

Ergebnisse

Das Tumormikromilieu mit seiner Vielzahl an Komponenten und Interaktionen ist ein wesentlicher Einflussfaktor auf die Therapie fortgeschrittener Melanome.

Diskussion

Innovative Ansätze, die auf immunsuppressive Komponenten des Tumormikromilieus abzielen, könnten in Kombination mit bereits etablierten Therapien zu einer weiteren Verbesserung des Therapieansprechens fortgeschrittener Melanome führen.

Abstract

Background

A considerable proportion of patients with advanced melanoma succumb to metastatic disease despite the initial success of modern therapies.

Objectives

An overview of the melanoma tumor microenvironment with special focus on approved therapies and new innovative strategies is given.

Methods

Current clinical trials and scientific insights concerning the impact of the tumor microenvironment on progression and therapy of advanced melanoma are reviewed and discussed.

Results

The tumor microenvironment with its manifold components and interactions plays a major role in the treatment of malignant melanoma.

Conclusion

Innovative new strategies that target an immunosuppressive microenvironment may improve the therapeutic efficacy of current treatment of advanced melanoma.

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Authors and Affiliations

  1. Klinik und Poliklinik für Dermatologie und Allergologie, Universitätsklinikum Bonn, Gebäude 11, Venusberg-Campus 1, 53127, Bonn, Deutschland

    Judith Sirokay

  2. Klinik für Dermatologie und Venerologie, Universitätsklinikum Köln, Köln, Deutschland

    Cornelia Mauch

Authors
  1. Judith Sirokay
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Corresponding author

Correspondence to Judith Sirokay.

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Interessenkonflikt

J. Sirokay hat Honorare für Vorträge, Beratertätigkeiten und Reiseunterstützung durch die Firmen Roche, MSD, BMS, Novartis und Pierre Fabre erhalten. Weiterhin bestand Förderung von Forschungsprojekten durch die Deutsche Dermatologische Gesellschaft und den Galderma Förderkreis e. V. C. Mauch hat Honorare und Reisekosten durch die Firmen Roche, MSD, BMS, Novartis und Pierre Fabre erhalten.

Für diesen Beitrag wurden von den Autorinnen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Sirokay, J., Mauch, C. Tumormikromilieu des Melanoms – Einfluss moderner Therapien. Dermatologie 73, 907–914 (2022). https://doi.org/10.1007/s00105-022-05078-2

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  • DOI: https://doi.org/10.1007/s00105-022-05078-2

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