Zusammenfassung
Die Histaminintoleranz ist eine klinisch heterogene Erkrankung. Wir berichten über eine Patientin, die seit Jahren unter Gewichtsverlust, Diarrhö, Bauch- und Kopfschmerzen, Flushsymptomatik und Asthma bronchiale litt und bei der eine Anorexia nervosa diagnostiziert worden war. Aufgrund des Verlaufs unter histaminarmer Eliminationsdiät mit kontinuierlicher Gewichtszunahme und Besserung sämtlicher Beschwerden konnte in Zusammenschau aller Befunde eine Histaminintoleranz diagnostiziert werden. Die Erkrankung sollte daher in die Differenzialdiagnosen der Anorexia nervosa einbezogen werden.
Abstract
Histamine intolerance is a clinically heterogeneous disease. We present a woman who suffered from weight loss, diarrhea, abdominal pain, headache, flushing and bronchial asthma for several years. When placed on a histamine-poor diet, she experienced weight gain and improvement of other all signs and symptoms, supporting the diagnosis of histamine intolerance. Therefore, this disease should be included in the differential diagnosis of anorexia nervosa.
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Literatur
Fairburn CG, Harrison PJ (2003) Eating disorders. Lancet 1;361(9355):407–416
Jarisch R (Hrsg) (2004) Histaminintoleranz, Histamin und Seekrankheit. Georg Thieme, Stuttgart
Kennedy MJ, Loehle JA, Griffin AR et al (2008) Association of the histamine N-methyltransferase C314T (Thr105Ile) polymorphism with atopic dermatitis in Caucasian children. Pharmacotherapy 28(12):1495–1501
Kuefner MA, Schwelberger HG, Ulrich P et al (2002) Total histamine degradation capacity (THDC) as an important biological marker of histamine metabolism in human colonic mucosa. Inflamm Res 51 (Suppl 1):S87–S88
Maintz L, Benfadal S, Allam J et al (2006) Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema. J Allergy Clin Immunol 117(5):1106–1112
Maintz L, Novak N (2007) Histamine and histamine intolerance. Am J Clin Nutr 85:1185–1196
Raithel M, Küfner M, Ulrich P, Hahn EG (1999) The involvement of the histamine degradation pathway by diamine oxidase in manifest gastrointestinal allergies. Inflamm Res 48 (Suppl 1):S75–S76
Raithel M, Ulrich P, Keymling J, Hahn EG (1998) Analysis and topographical distribution of gut diamine oxidase activity in patients with food allergy. Ann N Y Acad Sci 17(859):258–261
Sattler J, Hesterberg R, Lorenz W et al (1985) Inhibition of human and canine diamine oxidase by drugs used in an intensive care unit: relevance for clinical side effects? Agents Actions 16:91–94
Sattler J, Lorenz W (1990) Intestinal diamine oxidases and enteral-induced histaminosis: studies on three prognostic variables in an epidemiological model. J Neural Transm Suppl 32:291–314
Schwelberger HG (2004) Diamine oxidase (DAO) enzyme and gene. In: Falus A (ed) Histamine: biology and medical aspects. Spring Med Publishing, Budapest, pp 43–52
Wantke F, Götz M, Jarisch R (1993) Histamine-free diet: treatment of choice for histamine-induced food intolerance and supporting treatment for chronic headaches. Clin Exp Allergy 23:982–985
Wantke F, Hemmer W, Haglmuller T et al (1996) Histamine in wine. Bronchoconstriction after a double-blind placebo-controlled red wine provocation test. Int Arch Allergy Immunol 110:397–400
Zimatkin SM, Anichtchik OV (1999) Alcohol-histamine interactions. Alcohol Alcohol 34:141–147
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Stolze, I., Peters, KP. & Herbst, R. Histaminintoleranz imitiert Anorexia nervosa. Hautarzt 61, 776–778 (2010). https://doi.org/10.1007/s00105-009-1869-z
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DOI: https://doi.org/10.1007/s00105-009-1869-z