Skip to main content
Log in

Therapeutisches Management intraabdomineller und retroperitonealer Weichgewebssarkome

Therapeutic management of intra-abdominal and retroperitoneal soft tissue sarcomas

  • Leitthema
  • Published:
Der Chirurg Aims and scope Submit manuscript

Zusammenfassung

Gegenstand dieser Übersichtsarbeit ist die Diagnostik, Therapie, Nachsorge und Prognose intraabdomineller und retroperitonealer Weichgewebssarkome. Beschrieben und diskutiert werden chirurgische Verfahren, die Vor- und Nachteile verschiedener Formen und Kombinationen adjuvanter und neoadjuvanter Therapien, die Therapie bei Irresektabilität und das Vorgehen bei Desmoidtumoren. Behandlungsergebnisse, Überwachungsstrategien und Studien, die sich mit neuen Therapieansätzen beschäftigen, werden vorgestellt.

Abstract

In this article, we review the diagnostics, therapy, follow-up, and prognosis of intra-abdominal and retroperitoneal soft tissue sarcomas. There are descriptions and discussion of the surgical techniques, advantages and disadvantages of various types and combinations of adjuvant and neoadjuvant therapies, therapy in case of nonresectability, and procedures for desmoid tumors. Further, treatment results, control methods, and studies on new therapeutic approaches are presented.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3
Abb. 4
Abb. 5

Literatur

  1. Borden EC, Baker LH, Bell RS et al. (2003) Soft tissue sarcomas of adults: state of the translational science. Clin Cancer Res 9:1941–1956

    PubMed  Google Scholar 

  2. Catton CN, O’Sullivan B, Kotwall et al. (1994) Outcome and prognosis in retroperitoneal soft tissue sarcoma. Int J Radiat Oncol Biol Phys 29:1005–1010

    CAS  PubMed  Google Scholar 

  3. Coindre JM, Mariani O, Chibon F et al. (2003) Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytomas. Mod Pathol 16:256–262

    Article  PubMed  Google Scholar 

  4. vanDoorn RC, Gallee MP, Hart AA et al. (1994) Resectable retroperitoneal soft tissue sarcoma: the effect of extent of resection and postoperative radiation therapy on local tumor control. Cancer 73:637–742

    CAS  PubMed  Google Scholar 

  5. ESMO Guidelines Task Force (2003) Minimum clinical recommendations for diagnosis, treatment, and follow-up for soft tissue sarcomas. August 2003

  6. Glenn J, Sindelar WF, Kinsella T et al. (1985) Results of multimodality therapy of resectable soft tissue sarcomas of the retroperitoneum. Surgery 97:316–324

    CAS  PubMed  Google Scholar 

  7. Heslin MJ, Lewis JJ, Nadler E et al. (1997) Prognostic factors associated with long-term survival for retroperitoneal sarcoma: implications for management. J Clin Oncol 15:2832–2839

    CAS  PubMed  Google Scholar 

  8. Hollenbeck ST, Grobmyer SR, Kent KC et al. (2003) Surgical treatment and outcome of patients with primary inferior vena cava leiomyosarcoma. J Am Coll Surg 197:575–579

    Article  PubMed  Google Scholar 

  9. Ioannidis JPA, Lau J (2003) 18F-FDG PET for the diagnosis and grading of soft-tissue sarcoma: a meta-analysis. J Nucl Med 44:717–724

    PubMed  Google Scholar 

  10. Israel-Mardirosian N, Adler LP (2003) Positron emission tomography of soft tissue sarcomas. Curr Opin Oncol 15:327–330

    Article  PubMed  Google Scholar 

  11. Jaques DP, Coit DG, Hajdu SI, Brennan MF (1990) Management of primary and recurrent soft tissue sarcoma of the retroperitoneum. Ann Surg 212:51–59

    CAS  PubMed  Google Scholar 

  12. Jemal A, Tiwari RC, Murray T et al. (2004) Cancer statistics 2004. CA Cancer J Clin 54:8–29

    PubMed  Google Scholar 

  13. Kattan MW, Leung DH, Brennan MF (2002) Postoperative nomogram for 12-year sarcoma-specific death. J Clin Oncol 20:791–796

    Article  PubMed  Google Scholar 

  14. Lewis JJ, Leung DH, Woodruff JM, Brennan MF (1998) Retroperitoneal soft-tissue sarcoma: analysis of 500 patients treated and followed at a single institution. Ann Surg 228:355–365

    Article  CAS  PubMed  Google Scholar 

  15. Ling CC, Humm J, Larson S et al. (2000) Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality. Int J Radiation Oncology Biol Phys 47:551–560

    Article  CAS  Google Scholar 

  16. DeMatteo RP, Shah A, Fong Y et al. (2001) Results of hepatic resection for sarcoma metastatic to liver. Ann Surg 234:540–548

    Article  CAS  PubMed  Google Scholar 

  17. Nutting C, Dearnaley DB, Webb S (2000) Intensity modulated radiation therapy: a clinical review. Br J Radiol 73:459–469

    CAS  PubMed  Google Scholar 

  18. Pisters PWT, O’Sullivan B (2002) Retroperitoneal sarcomas: combined modality treatment approaches. Curr Opin Oncol 14:400–405

    Article  PubMed  Google Scholar 

  19. deSaint Aubain Somerhausen N, Fletcher CD (1999) Soft tissue sarcomas: an update. Eur J Surg Oncol 25:215–220

    Article  PubMed  Google Scholar 

  20. Shibata D, Lewis JJ, Leung DH, Brennan MF (2001) Is there a role for incomplete resection in the management of retroperitoneal liposarcomas? J Am Coll Surg 193:373–379

    Article  CAS  PubMed  Google Scholar 

  21. Singer S, Antonescu CR, Riedel E, Brennan MF (2003) Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Ann Surg 238:358–371

    PubMed  Google Scholar 

  22. Smith AJ, Lewis JJ, Merchant NB et al. (2000) Surgical management of intra-abdominal desmoid tumors. Br J Surg 87:608–613

    Article  CAS  PubMed  Google Scholar 

  23. Stojadinovic A, Yeh A, Brennan MF (2002) Completely resected recurrent soft tissue sarcoma: primary anatomic site governs outcomes. J Am Coll Surg 194:436–447

    Article  PubMed  Google Scholar 

Download references

Interessenkonflikt:

Keine Angaben

Author information

Authors and Affiliations

Authors

Additional information

Der Beitrag wurde übersetzt von Dr. Burkhard H. A. von Rahden, Chirurgische Klinik, Klinikum rechts der Isar, TU München.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wong, S., Brennan, M.F. Therapeutisches Management intraabdomineller und retroperitonealer Weichgewebssarkome. Chirurg 75, 1174–1181 (2004). https://doi.org/10.1007/s00104-004-0961-2

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00104-004-0961-2

Schlüsselwörter

Keywords

Navigation