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Hochmalignes Intimasarkom in einem Aneurysma der infrarenalen Bauchaorta

High-grade intimal sarcoma in an aneurysm of the infrarenal aorta

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Zusammenfassung

Primäre Intimasarkome der Aorta sind äußerst seltene und aggressive Tumoren mit einer Neigung in Knochen und viszeralen Organen, einschließlich Leber, Nieren, Nebennieren und Lunge, zu metastasieren. Die ersten Symptome sind oft unspezifisch und manifestieren sich häufig aufgrund embolischer Ereignisse. Wir berichten über einen Fall, bei dem sich ein primäres Intimasarkom als Überaschungsbefund in einem Aneurysma der Bauchaorta bei einem Patienten mit Klaudikatio aufgrund einer peripheren Embolisierung fand.

Abstract

Primary intimal sarcomas of the aorta are extremely rare and aggressive tumors metastasizing into bones and visceral organs including liver, kidneys, adrenal glands, and lung. The first symptoms are often nonspecific and often caused by arterial embolism. We report a case with an incidental finding of primary intimal sarcoma in an aneurysm of a patient with claudication due to tumor embolization.

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Literatur

  1. Akiyama K, Nakata K, Hasegawa M, Koga M, Negishi N (2002) Primary malignant tumor of the aorta. Zentralbl Chir 127(9): 791

    Article  CAS  PubMed  Google Scholar 

  2. Allenberg JR, Schuhmacher H, Kallinowski F, Eckstein H-H, Richter GM (1996) Klassifikation des infrarenalen Aortenaneurysmas (AAA) endovasculäre und konventionelle Chirurgie? Gefäßchirurgie 1: 21

  3. Auffermann H (1912) Primäre Aortengeschwulst mit eigentümlichen Riesenzellen. Z Krebsforsch 11: 294

    Google Scholar 

  4. Becquemin J, Lebbe C, Saada F, Avril M (1988) Sarcoma of the aorta: report of a case and review of the literature. Ann Vasc Surg 2: 225

    CAS  PubMed  Google Scholar 

  5. Bertucci F, Baume D, Viens P et al. (1995) Sarcoma of the aortic intima: a rare cause of arterial embolism. Presse Med 24(3): 196

    CAS  Google Scholar 

  6. Breborovicz D, Handschuh K (1972) Primary aortic sarcomas: Own vase and review of the literature. Nowotwory 22: 309

    CAS  PubMed  Google Scholar 

  7. Brodowski W (1873) Primäres Sarkom der Aorta thoracica mit Verbreitung des Neugebildes in der unteren Körperhälfte. Jahresb Leistung Fortschr ges Med 8: 243

    Google Scholar 

  8. Burke AP, Virmani R (1993) Sarcomas of the great vessels. Cancer 71: 1761

    CAS  PubMed  Google Scholar 

  9. Caiati JM, Marin ML, Flores RM, Smith CR, Martin EC, Todd GL (2001) Endovascular manafement of an aortobronchial fistula arising after resection of a primary aortic sarcoma: a caes report. Vasc Surg 35(1): 73

    CAS  PubMed  Google Scholar 

  10. Campagnoni G, Matsumura JS, Nemcek A, McCarthy WJ (1997) Sacoma arairing from an abdominal aortic aneurysm. Ann Vasc Surg 11(2): 183

    Article  CAS  PubMed  Google Scholar 

  11. Clark N, Goldenkranz RJ, Maeuser H et al. (1998) Chondrosarkcoma of the aorta: a rare source of bowel and lower extremity emboli. J Vasc Surg 28 (5): 939

    CAS  PubMed  Google Scholar 

  12. Crum CP, Feldman PS, Nolan SP (1978) Primary fibroxanthosarcoma of the thoracic aorta. Virchows Arch A Pathol Anat Histol 379(4): 351

    CAS  PubMed  Google Scholar 

  13. Dalla Pria AF, Piaserico PL, Puglisi A, Piaserico GP (1977) Primary tumor of blood-vessel walls: apropos of a case of fibrosarcoma of the aortic arch. Arch De Vecchi Anat Patol 62(1): 155

    PubMed  Google Scholar 

  14. Daniel L, Figarella-Branger D, Tournigand P, Hassoun J Pellisier J (1997) Aortic sarcomas with peripheral emboli: apropos of 2 cases. Rev Med Interne 18(19): 799

    Article  CAS  PubMed  Google Scholar 

  15. Dux M, Noldge G, Schuhmacher H, Mechtersheimer G, Scharf J, Roeren T (1995) Angiosarcoma of the aorta—a case report. Rofo Fortschr Geb Roentgenstr Neuen Bidgeb Verfahr 163(4): 361

    CAS  Google Scholar 

  16. Fehrenbacher JW, Bowers W, Strate R, Pittmann J (1981) Angiosarcoma of the Aorta associated with Dacron graft. Ann Thorac Surg 32: 297

    CAS  PubMed  Google Scholar 

  17. Fitzmaurice RJ, McClure J (1990) Aortic intimal sarcoma: an anusual case with pulmonary vasculature involvement. Histopathology 17: 457

    CAS  PubMed  Google Scholar 

  18. Fusade T, Boullie MC, Thomine E, Lauret P (1991) Métastases cutanées révélatrices d’un angiosarcome aortique primitif. Ann dermatol Venereol 118: 701

    CAS  PubMed  Google Scholar 

  19. Fyfe BS, Quintana CS, Kaneko M, Griepp RB (1994) Aortic sarcoma four years after Dacron graft insertion. Ann Thorac Surg 58(6): 1752

    CAS  PubMed  Google Scholar 

  20. Ghanem N, Riede U, Uhrmeister P, Weigand E, Altehoefer C (2002) Epitheloid Angiosarcoma of the Aorta. Vasa 31(4): 269

    CAS  PubMed  Google Scholar 

  21. Gittlemann AM, Luchs JS, Hom M, Mohtashemi M, Hennawy RP, Katz DS (2002) Angiosarcoma of the Aorta. J Vasc Intervent Radiol 13(2 Pt 1): 214

    Google Scholar 

  22. Glock Y, Laghzaoui A, Wang J et al. (1997) Arch Mal Coeur Vaiss 90(9): 1317

    CAS  PubMed  Google Scholar 

  23. Haber LM, Truong L (1988) Immunohistochemical demonstration of the endothelial nuture of aortic intimal sarcoma. Am J Surg Pathol 12(10): 798

    CAS  PubMed  Google Scholar 

  24. Hashimoto M, Sashi R, Watarai J (1997) Primary sarcoma of the aortic wall. Cardiovasc Intervent Radiol 20: 322

    Article  CAS  PubMed  Google Scholar 

  25. Hermanek P Jr, Grentsch HH, Scheele J (1985) Malignant tumors of the large vessels. 2 case reports. Chirurg 56(2): 120

    PubMed  Google Scholar 

  26. Hernandez FJ, Stanley TM, Ranganath KA, Rubinstein AI (1979) Primary Leiomyosarcoma of the aorta. Am J Surg Pathol 3(3): 251

    CAS  PubMed  Google Scholar 

  27. Herzberg AJ, Pizzo SV (1988) Primary undufferentiated sarcoma of the thoracic aorta. Histopathology 13(5): 571

    CAS  PubMed  Google Scholar 

  28. Higgins R, Posner MC, Moosa HH, Staley C, Pataki KI, Mendelow H (1991) Mesenteric infarction secondary to tumor emboli from primary aortic sarcoma. Guidelines for diagnosis and management. Cancer 68(7): 1622

    CAS  PubMed  Google Scholar 

  29. Honda K, Hara M, Miyakoshi S, Yanagashita M (1990) Characterization of myxoid substance of human aortic sarcoma. Acta Pathologic Jpn 40: 531

    CAS  Google Scholar 

  30. Hottenrott G, Mentzel T, Peters A, Schröder A, Katenkamp D (1999) Intravascular („intimal“) epitheloid angiosarcoma: clinicopathological and immunohostochemical analysis of thre cases. Virchows Arch 435: 473

    Article  CAS  PubMed  Google Scholar 

  31. Ingeholm P, Engel P (1997) Metastasizing sarcoma of the aorta. A case report. APMIS 105(8): 609

    CAS  PubMed  Google Scholar 

  32. Iorgulescu DG, White AL (1999) Leiomyosarcoma of the thoracic aorta. Aust N Z J Surg 69(7): 537

    Article  CAS  PubMed  Google Scholar 

  33. Josen AS, Khine M (1989) Primary malignant tumor of the aorta. J Vasc Surg 9(3): 493

    Article  CAS  PubMed  Google Scholar 

  34. Kaigorodova P, Berezovskaya E (1963) Endothelioma of the thoracic aorta. Grudnaya Khirurgiya 4: 88

    Google Scholar 

  35. Kantelip B, de Riberolles C, Bailly P, Citron B (1989) Primary Endotheliosarcoma of the thoracic aorta. Pathologica 81(1072): 163

    CAS  PubMed  Google Scholar 

  36. Karabinis VD, Arnold TE, Hameed M, Onohara T, Sariego J, Kerste MD, Matsumoto T (1993) Myxoid Chondrosarcoma of the abdominal aorta. Int Surg 78(1): 59

    CAS  PubMed  Google Scholar 

  37. Karhoff B (1952) Primärtumor der Aorta. Zentralbl Allg Pathol 89: 46

    Google Scholar 

  38. Kattus A, Longmire W, Cannon J, Webb R, Johnston C (1960) Primary intimal tumor of aorta producing malignant hypertension. N Engl J Med 262: 694

    PubMed  Google Scholar 

  39. Khan A, Jilani F, Kaye S, Greenberg BR (1997) Aortic wall sarcoma with tumor emboli and peripheral ischemia: case report with review of the literature. Am J Clin Oncol 20(1): 73

    Article  CAS  PubMed  Google Scholar 

  40. Kim SH, Jeong JY, Kim YI, Choi YH, Chung JW, Hyung Park J (2002) SCVIR 2002 Film Panel case 3: aortiv occlusion secondary to intimal sarcoma. J Vasc Interv Radiol 13(5): 537

    PubMed  Google Scholar 

  41. Kovaleva AN, Press BO (1959) A case of primary sarcoma of the intimal of the aorta. Arkh Pathol 21(10): 62

    Google Scholar 

  42. Kunkel D, Duval Jl, Bouchiat C, Talard P, Dubayle P, Carloz E, Flandrin P (1993) Angiosarcoma of the aorta revealed by intestinal metastases. Gastroenterol Clin Biol 17(2): 139

    CAS  PubMed  Google Scholar 

  43. Le Rochais JP, Icard P, Coffin O, Galateau F, Khalil M, Maiza D (1999) Intimal sarcoma of the thoracic aorta: a case report. Eur J Vasc Endovasc Surg 18(2): 181

    Article  CAS  PubMed  Google Scholar 

  44. Lescalie F, Moreau P, Enon B, Chavalier JM, Pillet J, Simard C (1988) Aortic sarcoma. A rare pathology. J Chir (Paris) 125(8–9): 497

    Google Scholar 

  45. Majeski J, Crawford ES, Majeski EI, Duttenhaver JR (1998) Primary aortic intimal sarcoma of the endothelial cell type with long-term survival. J Vasc Surg 27(3): 555

    CAS  PubMed  Google Scholar 

  46. Malone MD, Kerr K, Kavanah M, Menzoian JO (1996) Primary leiomyosarcoma of the abdominal aorta. J Vasc Surg 24(3): 487

    CAS  PubMed  Google Scholar 

  47. Mason MS, Wheeler JR, Gregory RT (1982) Primary tumors of the Aorta: report of a case and review of the literature. Oncology 39: 167

    CAS  PubMed  Google Scholar 

  48. Millili JJ, La Flare RG, Nemir P Jr (1981) Leiomyosarcoma of the abdominal aorta: a case report. Surgery 89(5): 631

    CAS  PubMed  Google Scholar 

  49. Miracco C, Laurini L, Santopietro R et al. (1999) Itimal-type primari sarcoma of the aorta. Report of a case with evidence of rhabdomyosarcomatous differentiation. Virchows Arch 435(1): 62

    Article  CAS  PubMed  Google Scholar 

  50. Miura M (1891) Das primäre Riesenzellsarkom der Aorta thoracica. Int Beitr Wissensch Festschr R Virchow 2: 249

    Google Scholar 

  51. Moeser P, Perlmutt LM, Moore J, Rinker GE (1986) Primary intraaortic malignancy—a case report. Cardiovasc Intervent Radiol 9(4): 183

    Google Scholar 

  52. Mohsen NA, Haber M, Urrutia VC, Nunes LW (2000) Intimal sarcoma of the aorta. Am J Roentgenol 175(5): 1289

    CAS  Google Scholar 

  53. Muehlstedt S, Mallery S, Joyce L, Van Camp J (2001) Myxoid leiomyosarcoma of the descending thoracic aorta. J Thorac Cardiovasc Surg 121(3): 590

    Article  CAS  PubMed  Google Scholar 

  54. Nanjo H, Murakami M, Ebini T et al. (1996) Aortic intimal sarcoma with acute myocardial infarction. Pathol Int 46(9): 673

    CAS  PubMed  Google Scholar 

  55. Navarra G, Occionorelli S, Mascoli F, Santini M, Benea G, Marzola A (1994) Primary leiomyosarcoma of the aorta: report of a case and a review of the literature. J Cardiovasc Surg 35(4): 333

    CAS  Google Scholar 

  56. Nencki L (1946) Zur Kentnis der Primärtumoren der großen Gefäßstämme. Über einen Fall von primärem Sarkom der Aorta abdominalis. Cardiologia (Basel) 10: 1

    Google Scholar 

  57. Neri E, Miracco C, Luzi P, Carone E, Tripodi A, Sassi C (1999) Intimal-type primary sarcoma of the thoracic aorta presenting as a saccular false aneurysm: report of a case with evidence of rhabdomyosarcomatous differentiation. J Thorac Cardiovasc Surg 118(2): 371

    CAS  PubMed  Google Scholar 

  58. Nishida N, Yutani C, Ishibashi-Ueda H, Tsukamoto Y, Ikeda Y, Nakamura y (2000) Histopathological characterization of aortic intimal sarcomwith multiple tumor emboli. Pathol int 50(11): 923

    Article  CAS  PubMed  Google Scholar 

  59. Nishikawa H, Miyakoshi S, Nishomura S, Seki A, Honda K (1989) A case of aortic intimal sarcoma manifested with acutely occuringhypertension and aortic occlusion. Heart Vessels 5: 54

    CAS  PubMed  Google Scholar 

  60. O’Connell TX, Fee HJ, Golding A (1976) Sarcoma associated with dacron prosthetic material: a case report and review of the literature. J Thorac Cardiovasc Surg 72(1): 94

    CAS  PubMed  Google Scholar 

  61. Owens WD, Felts JA, Spitznagel EL (1978) ASA Physical Status Classification. Anesthesiology 49: 239

    CAS  PubMed  Google Scholar 

  62. Patel KR, Niazi TB, Griffiths AP, Hardy GJ, Mac Laren CA, Reid IN (1997) Hum Pathol 28(11): 1306

    CAS  PubMed  Google Scholar 

  63. Pompilio G, Tartara P, Varesi C, Biglioli P (2002) Intimal-tyoe primary sarcoma of the thoracic aorta: an anusual case presenting with left arm embolization. Eur J Cardiothorac Surg 21(3): 574

    Article  PubMed  Google Scholar 

  64. Pruszcynski M, Coronel CM, Naudin ten Cate L, Roholl PJ, van der Kley AJ (1988) Immunohistochemical and ultrastructural studies of a primary aortic intimal sarcoma. Pathology 20(2): 173

    PubMed  Google Scholar 

  65. Rhee MY, Myong NH, Park YB (2002) Primary intimal sarcoma of the aorta: role of transesophageal echocardiography. Circ J 66(1): 111

    Article  PubMed  Google Scholar 

  66. Ronaghi AH, Roberts AC, Rosenkrantz H (1994) Intraaortic biopsy of a primary aortic tumor. J Vasc Radiol 5(5): 777

    CAS  Google Scholar 

  67. Rudd RJ, Fair KP, Patterson JW (2000) Aortic sarcoma presenting with cutaneous metestasis: case report and review of the literature. J Am Acad Dermatol 43(5): 930

    Article  CAS  PubMed  Google Scholar 

  68. Ruijter ET, Ten Kate FL (1996) Metastasising sarcoma of the aorta. Histopathology 29(3): 278

    CAS  PubMed  Google Scholar 

  69. Salm R (1972) Primary fibrosarcoma of aorta. Cancer 29(1): 73

    CAS  PubMed  Google Scholar 

  70. Sanchez-Munoz A, Hitt R, Artiles V, Lopez A, Hernandez R, Cortes-Funes H, Colomer R (2003) Primary aortic sarcoma with widespread vascular embolic metastases. Eur J Intern Med 14(4): 258

    Article  PubMed  Google Scholar 

  71. Santonja C, Martin-Hita AM, Dotor A, Costa-Subias J (2001) Intimal angiosarcoma of the aorta with tumor embolization causing mesenteric ischaemia. Report of a case using CD 31 immunhistichemistry in am intestinal resektion specimen. Virchows Arch 438(4): 404

    Article  CAS  PubMed  Google Scholar 

  72. Sato S, Tamada Y, Kaitsuma S et al. (2002) Autopsy case of aortic intimal sarcomas with severe hypertension and congestive heart failure. Nippon Naika Gakkai Zasshi 91(4): 1323

    PubMed  Google Scholar 

  73. Schipper J, van Oostayen JA, den Hollander JC, van Seyen AJ (1989) Aortic tumors: report of a case and review of the literature. Br J Radiol 62(733): 35

    CAS  PubMed  Google Scholar 

  74. Schuhmacher H, Eckstein H-H, Allenberg JR (1999) Gefäßendoprothetik: Entwicklung, aktueller Stand und Perspektiven einer neuen Technologie. Chirurg 70: 858

    Article  CAS  PubMed  Google Scholar 

  75. Seelig M, Klingler P, Oldenburg A, Blacksear J (1998) Angiosarcoma of the Aorta: report of a case and review of the literature. J Vasc Surg 28: 732

    CAS  PubMed  Google Scholar 

  76. Sekine S, Abe T, Seki K, Shibata Y, Yamagashi I (1995) Primary aortic sarcoma: resection by total arch replacement. J Thorac Cardiovasc Surg 110(2): 554

    CAS  PubMed  Google Scholar 

  77. Settmacher U, Heise M, Dette K, Frei U, Neuhaus P (1997) Primary malignant tumor of the aorta. Langenbecks Arch Chir 382(3): 138

    Article  CAS  PubMed  Google Scholar 

  78. Shuster TA, Dall’Olmo CA, Spadone D, Silver D (2002) Abdominal aortic sarcoma: report of a case with long term survival and a review of the literature. Ann Vasc Surg 16(5): 545

    Article  PubMed  Google Scholar 

  79. Simpson WL Jr, Mendelson DS (2000) Pilmonary artery and aortic sarcomas: cross-sectional imaging. J Thorac Imaging 15(4): 290

    Article  CAS  PubMed  Google Scholar 

  80. Sladden R (1964) Neoplasia of the aortic intima. J Clin Pathol 17: 602

    CAS  PubMed  Google Scholar 

  81. Smeloff E, Reece J, Maters J (1965) Primary malignant tumor of the aorta. Am J Cardiol 15: 107

    CAS  PubMed  Google Scholar 

  82. Steckmeier B (2001) Epidemiologie der Aortenerkrankung: Aneurysma, Dissektion, Verschluss. Radiologe 41(8): 624

    Article  CAS  PubMed  Google Scholar 

  83. Steffelaar JW, van der Heul RO, Blackstone E, Vos A (1975) Primary sarcoma of the aorta. Arch Pathol 99(3): 139

    CAS  PubMed  Google Scholar 

  84. Steinberg JB, Johnson ER, Benda JA, Lanza LA (1993) Primary leiomyosarkoma of the thoracic aorta presenting as a contained rupture. Ann Thorac Surg 56(6): 1387

    CAS  PubMed  Google Scholar 

  85. Stevenson JE, Burkhead H, Trueheart RE, McLaren J (1971) Primary malignant tumor of the aorta. Am J Med 51(4): 553

    CAS  PubMed  Google Scholar 

  86. Suzuki M, Shimoda T, Ushigome S, Aizawa S (1989) Leiomyosarkoma of the thoracic aorta with dissecting aneurysm. Acta Pathol Jpn 39(5): 336

    CAS  PubMed  Google Scholar 

  87. Szekely E, Kulka J, Miklos I, Kaliszky P (2000) Leiomyosarcomas of the great vessels. Pathol Oncol Res 6(3): 233

    CAS  PubMed  Google Scholar 

  88. Tajeda E, Becker GJ, Waller BF (1991) Malignant myxoid emboli as the presenting feature of primary sarcoma of the aorta (myxoid malignant fibrous histiocytoma): a case report and review of the literature. Clin Cardiol 14(5): 425

    CAS  PubMed  Google Scholar 

  89. Talard P, Lemmens B, Duval JL, Dubayle P, Bouchiat C, Carloz E (1992) Angiosarcoma of the aorta disclosed by intestinal metastases. Arch Mal Coeur Vaiss 85(5): 453

    CAS  PubMed  Google Scholar 

  90. Testini M, Todisco C, Simone M et al. (1996) Treatment of haemorrhage following rupture of aortic leiomyosarcoma. Survival for 4.2 years. J Cardiovasc Surg 37(6): 593

    CAS  Google Scholar 

  91. Weinberg DS, Maini BS (1980) Primary sarcoma of the aorta associated with vascular prosthesis: a case report. Cancer 46(2): 398

    CAS  PubMed  Google Scholar 

  92. Weiss WM, Riles ST, Gouge TH, Mizrachi HH (1991) Angiosarcoma at the site of a Dacron vascular prothesis: a case report and literature review. J Vasc Surg 14(1): 87

    Article  CAS  PubMed  Google Scholar 

  93. Winkelmann RK, van Heerden JA, Bernatz PE (1971) Malignant vascular endothelial tumor with distal embolization. Am J Med 51: 692

    CAS  PubMed  Google Scholar 

  94. Wright EP, Glick AD, Virmani R, Page DL (1985) Aortic intimal sarcoma with embolic metastases. Am J Surg Pathol 9(12): 890

    CAS  PubMed  Google Scholar 

  95. Yasuda T, Yamamoto S, Yamaguchi S, Ishida Y (1999) Leiomyosarcoma of the thoracic aorta. Jpn J Thorac Cardiovasc Surg 47(10): 510

    CAS  PubMed  Google Scholar 

  96. Zeitlhofer J, Holzner JH, Krepler P (1963) Primates Fibromyosarkom der Aorta. Krebsarzt 18: 259

    CAS  PubMed  Google Scholar 

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Osei-Agyemang, T., Geks, J., Wagner, HJ. et al. Hochmalignes Intimasarkom in einem Aneurysma der infrarenalen Bauchaorta. Chirurg 75, 823–827 (2004). https://doi.org/10.1007/s00104-004-0830-z

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