Zusammenfassung
Primäre Intimasarkome der Aorta sind äußerst seltene und aggressive Tumoren mit einer Neigung in Knochen und viszeralen Organen, einschließlich Leber, Nieren, Nebennieren und Lunge, zu metastasieren. Die ersten Symptome sind oft unspezifisch und manifestieren sich häufig aufgrund embolischer Ereignisse. Wir berichten über einen Fall, bei dem sich ein primäres Intimasarkom als Überaschungsbefund in einem Aneurysma der Bauchaorta bei einem Patienten mit Klaudikatio aufgrund einer peripheren Embolisierung fand.
Abstract
Primary intimal sarcomas of the aorta are extremely rare and aggressive tumors metastasizing into bones and visceral organs including liver, kidneys, adrenal glands, and lung. The first symptoms are often nonspecific and often caused by arterial embolism. We report a case with an incidental finding of primary intimal sarcoma in an aneurysm of a patient with claudication due to tumor embolization.
Literatur
Akiyama K, Nakata K, Hasegawa M, Koga M, Negishi N (2002) Primary malignant tumor of the aorta. Zentralbl Chir 127(9): 791
Allenberg JR, Schuhmacher H, Kallinowski F, Eckstein H-H, Richter GM (1996) Klassifikation des infrarenalen Aortenaneurysmas (AAA) endovasculäre und konventionelle Chirurgie? Gefäßchirurgie 1: 21
Auffermann H (1912) Primäre Aortengeschwulst mit eigentümlichen Riesenzellen. Z Krebsforsch 11: 294
Becquemin J, Lebbe C, Saada F, Avril M (1988) Sarcoma of the aorta: report of a case and review of the literature. Ann Vasc Surg 2: 225
Bertucci F, Baume D, Viens P et al. (1995) Sarcoma of the aortic intima: a rare cause of arterial embolism. Presse Med 24(3): 196
Breborovicz D, Handschuh K (1972) Primary aortic sarcomas: Own vase and review of the literature. Nowotwory 22: 309
Brodowski W (1873) Primäres Sarkom der Aorta thoracica mit Verbreitung des Neugebildes in der unteren Körperhälfte. Jahresb Leistung Fortschr ges Med 8: 243
Burke AP, Virmani R (1993) Sarcomas of the great vessels. Cancer 71: 1761
Caiati JM, Marin ML, Flores RM, Smith CR, Martin EC, Todd GL (2001) Endovascular manafement of an aortobronchial fistula arising after resection of a primary aortic sarcoma: a caes report. Vasc Surg 35(1): 73
Campagnoni G, Matsumura JS, Nemcek A, McCarthy WJ (1997) Sacoma arairing from an abdominal aortic aneurysm. Ann Vasc Surg 11(2): 183
Clark N, Goldenkranz RJ, Maeuser H et al. (1998) Chondrosarkcoma of the aorta: a rare source of bowel and lower extremity emboli. J Vasc Surg 28 (5): 939
Crum CP, Feldman PS, Nolan SP (1978) Primary fibroxanthosarcoma of the thoracic aorta. Virchows Arch A Pathol Anat Histol 379(4): 351
Dalla Pria AF, Piaserico PL, Puglisi A, Piaserico GP (1977) Primary tumor of blood-vessel walls: apropos of a case of fibrosarcoma of the aortic arch. Arch De Vecchi Anat Patol 62(1): 155
Daniel L, Figarella-Branger D, Tournigand P, Hassoun J Pellisier J (1997) Aortic sarcomas with peripheral emboli: apropos of 2 cases. Rev Med Interne 18(19): 799
Dux M, Noldge G, Schuhmacher H, Mechtersheimer G, Scharf J, Roeren T (1995) Angiosarcoma of the aorta—a case report. Rofo Fortschr Geb Roentgenstr Neuen Bidgeb Verfahr 163(4): 361
Fehrenbacher JW, Bowers W, Strate R, Pittmann J (1981) Angiosarcoma of the Aorta associated with Dacron graft. Ann Thorac Surg 32: 297
Fitzmaurice RJ, McClure J (1990) Aortic intimal sarcoma: an anusual case with pulmonary vasculature involvement. Histopathology 17: 457
Fusade T, Boullie MC, Thomine E, Lauret P (1991) Métastases cutanées révélatrices d’un angiosarcome aortique primitif. Ann dermatol Venereol 118: 701
Fyfe BS, Quintana CS, Kaneko M, Griepp RB (1994) Aortic sarcoma four years after Dacron graft insertion. Ann Thorac Surg 58(6): 1752
Ghanem N, Riede U, Uhrmeister P, Weigand E, Altehoefer C (2002) Epitheloid Angiosarcoma of the Aorta. Vasa 31(4): 269
Gittlemann AM, Luchs JS, Hom M, Mohtashemi M, Hennawy RP, Katz DS (2002) Angiosarcoma of the Aorta. J Vasc Intervent Radiol 13(2 Pt 1): 214
Glock Y, Laghzaoui A, Wang J et al. (1997) Arch Mal Coeur Vaiss 90(9): 1317
Haber LM, Truong L (1988) Immunohistochemical demonstration of the endothelial nuture of aortic intimal sarcoma. Am J Surg Pathol 12(10): 798
Hashimoto M, Sashi R, Watarai J (1997) Primary sarcoma of the aortic wall. Cardiovasc Intervent Radiol 20: 322
Hermanek P Jr, Grentsch HH, Scheele J (1985) Malignant tumors of the large vessels. 2 case reports. Chirurg 56(2): 120
Hernandez FJ, Stanley TM, Ranganath KA, Rubinstein AI (1979) Primary Leiomyosarcoma of the aorta. Am J Surg Pathol 3(3): 251
Herzberg AJ, Pizzo SV (1988) Primary undufferentiated sarcoma of the thoracic aorta. Histopathology 13(5): 571
Higgins R, Posner MC, Moosa HH, Staley C, Pataki KI, Mendelow H (1991) Mesenteric infarction secondary to tumor emboli from primary aortic sarcoma. Guidelines for diagnosis and management. Cancer 68(7): 1622
Honda K, Hara M, Miyakoshi S, Yanagashita M (1990) Characterization of myxoid substance of human aortic sarcoma. Acta Pathologic Jpn 40: 531
Hottenrott G, Mentzel T, Peters A, Schröder A, Katenkamp D (1999) Intravascular („intimal“) epitheloid angiosarcoma: clinicopathological and immunohostochemical analysis of thre cases. Virchows Arch 435: 473
Ingeholm P, Engel P (1997) Metastasizing sarcoma of the aorta. A case report. APMIS 105(8): 609
Iorgulescu DG, White AL (1999) Leiomyosarcoma of the thoracic aorta. Aust N Z J Surg 69(7): 537
Josen AS, Khine M (1989) Primary malignant tumor of the aorta. J Vasc Surg 9(3): 493
Kaigorodova P, Berezovskaya E (1963) Endothelioma of the thoracic aorta. Grudnaya Khirurgiya 4: 88
Kantelip B, de Riberolles C, Bailly P, Citron B (1989) Primary Endotheliosarcoma of the thoracic aorta. Pathologica 81(1072): 163
Karabinis VD, Arnold TE, Hameed M, Onohara T, Sariego J, Kerste MD, Matsumoto T (1993) Myxoid Chondrosarcoma of the abdominal aorta. Int Surg 78(1): 59
Karhoff B (1952) Primärtumor der Aorta. Zentralbl Allg Pathol 89: 46
Kattus A, Longmire W, Cannon J, Webb R, Johnston C (1960) Primary intimal tumor of aorta producing malignant hypertension. N Engl J Med 262: 694
Khan A, Jilani F, Kaye S, Greenberg BR (1997) Aortic wall sarcoma with tumor emboli and peripheral ischemia: case report with review of the literature. Am J Clin Oncol 20(1): 73
Kim SH, Jeong JY, Kim YI, Choi YH, Chung JW, Hyung Park J (2002) SCVIR 2002 Film Panel case 3: aortiv occlusion secondary to intimal sarcoma. J Vasc Interv Radiol 13(5): 537
Kovaleva AN, Press BO (1959) A case of primary sarcoma of the intimal of the aorta. Arkh Pathol 21(10): 62
Kunkel D, Duval Jl, Bouchiat C, Talard P, Dubayle P, Carloz E, Flandrin P (1993) Angiosarcoma of the aorta revealed by intestinal metastases. Gastroenterol Clin Biol 17(2): 139
Le Rochais JP, Icard P, Coffin O, Galateau F, Khalil M, Maiza D (1999) Intimal sarcoma of the thoracic aorta: a case report. Eur J Vasc Endovasc Surg 18(2): 181
Lescalie F, Moreau P, Enon B, Chavalier JM, Pillet J, Simard C (1988) Aortic sarcoma. A rare pathology. J Chir (Paris) 125(8–9): 497
Majeski J, Crawford ES, Majeski EI, Duttenhaver JR (1998) Primary aortic intimal sarcoma of the endothelial cell type with long-term survival. J Vasc Surg 27(3): 555
Malone MD, Kerr K, Kavanah M, Menzoian JO (1996) Primary leiomyosarcoma of the abdominal aorta. J Vasc Surg 24(3): 487
Mason MS, Wheeler JR, Gregory RT (1982) Primary tumors of the Aorta: report of a case and review of the literature. Oncology 39: 167
Millili JJ, La Flare RG, Nemir P Jr (1981) Leiomyosarcoma of the abdominal aorta: a case report. Surgery 89(5): 631
Miracco C, Laurini L, Santopietro R et al. (1999) Itimal-type primari sarcoma of the aorta. Report of a case with evidence of rhabdomyosarcomatous differentiation. Virchows Arch 435(1): 62
Miura M (1891) Das primäre Riesenzellsarkom der Aorta thoracica. Int Beitr Wissensch Festschr R Virchow 2: 249
Moeser P, Perlmutt LM, Moore J, Rinker GE (1986) Primary intraaortic malignancy—a case report. Cardiovasc Intervent Radiol 9(4): 183
Mohsen NA, Haber M, Urrutia VC, Nunes LW (2000) Intimal sarcoma of the aorta. Am J Roentgenol 175(5): 1289
Muehlstedt S, Mallery S, Joyce L, Van Camp J (2001) Myxoid leiomyosarcoma of the descending thoracic aorta. J Thorac Cardiovasc Surg 121(3): 590
Nanjo H, Murakami M, Ebini T et al. (1996) Aortic intimal sarcoma with acute myocardial infarction. Pathol Int 46(9): 673
Navarra G, Occionorelli S, Mascoli F, Santini M, Benea G, Marzola A (1994) Primary leiomyosarcoma of the aorta: report of a case and a review of the literature. J Cardiovasc Surg 35(4): 333
Nencki L (1946) Zur Kentnis der Primärtumoren der großen Gefäßstämme. Über einen Fall von primärem Sarkom der Aorta abdominalis. Cardiologia (Basel) 10: 1
Neri E, Miracco C, Luzi P, Carone E, Tripodi A, Sassi C (1999) Intimal-type primary sarcoma of the thoracic aorta presenting as a saccular false aneurysm: report of a case with evidence of rhabdomyosarcomatous differentiation. J Thorac Cardiovasc Surg 118(2): 371
Nishida N, Yutani C, Ishibashi-Ueda H, Tsukamoto Y, Ikeda Y, Nakamura y (2000) Histopathological characterization of aortic intimal sarcomwith multiple tumor emboli. Pathol int 50(11): 923
Nishikawa H, Miyakoshi S, Nishomura S, Seki A, Honda K (1989) A case of aortic intimal sarcoma manifested with acutely occuringhypertension and aortic occlusion. Heart Vessels 5: 54
O’Connell TX, Fee HJ, Golding A (1976) Sarcoma associated with dacron prosthetic material: a case report and review of the literature. J Thorac Cardiovasc Surg 72(1): 94
Owens WD, Felts JA, Spitznagel EL (1978) ASA Physical Status Classification. Anesthesiology 49: 239
Patel KR, Niazi TB, Griffiths AP, Hardy GJ, Mac Laren CA, Reid IN (1997) Hum Pathol 28(11): 1306
Pompilio G, Tartara P, Varesi C, Biglioli P (2002) Intimal-tyoe primary sarcoma of the thoracic aorta: an anusual case presenting with left arm embolization. Eur J Cardiothorac Surg 21(3): 574
Pruszcynski M, Coronel CM, Naudin ten Cate L, Roholl PJ, van der Kley AJ (1988) Immunohistochemical and ultrastructural studies of a primary aortic intimal sarcoma. Pathology 20(2): 173
Rhee MY, Myong NH, Park YB (2002) Primary intimal sarcoma of the aorta: role of transesophageal echocardiography. Circ J 66(1): 111
Ronaghi AH, Roberts AC, Rosenkrantz H (1994) Intraaortic biopsy of a primary aortic tumor. J Vasc Radiol 5(5): 777
Rudd RJ, Fair KP, Patterson JW (2000) Aortic sarcoma presenting with cutaneous metestasis: case report and review of the literature. J Am Acad Dermatol 43(5): 930
Ruijter ET, Ten Kate FL (1996) Metastasising sarcoma of the aorta. Histopathology 29(3): 278
Salm R (1972) Primary fibrosarcoma of aorta. Cancer 29(1): 73
Sanchez-Munoz A, Hitt R, Artiles V, Lopez A, Hernandez R, Cortes-Funes H, Colomer R (2003) Primary aortic sarcoma with widespread vascular embolic metastases. Eur J Intern Med 14(4): 258
Santonja C, Martin-Hita AM, Dotor A, Costa-Subias J (2001) Intimal angiosarcoma of the aorta with tumor embolization causing mesenteric ischaemia. Report of a case using CD 31 immunhistichemistry in am intestinal resektion specimen. Virchows Arch 438(4): 404
Sato S, Tamada Y, Kaitsuma S et al. (2002) Autopsy case of aortic intimal sarcomas with severe hypertension and congestive heart failure. Nippon Naika Gakkai Zasshi 91(4): 1323
Schipper J, van Oostayen JA, den Hollander JC, van Seyen AJ (1989) Aortic tumors: report of a case and review of the literature. Br J Radiol 62(733): 35
Schuhmacher H, Eckstein H-H, Allenberg JR (1999) Gefäßendoprothetik: Entwicklung, aktueller Stand und Perspektiven einer neuen Technologie. Chirurg 70: 858
Seelig M, Klingler P, Oldenburg A, Blacksear J (1998) Angiosarcoma of the Aorta: report of a case and review of the literature. J Vasc Surg 28: 732
Sekine S, Abe T, Seki K, Shibata Y, Yamagashi I (1995) Primary aortic sarcoma: resection by total arch replacement. J Thorac Cardiovasc Surg 110(2): 554
Settmacher U, Heise M, Dette K, Frei U, Neuhaus P (1997) Primary malignant tumor of the aorta. Langenbecks Arch Chir 382(3): 138
Shuster TA, Dall’Olmo CA, Spadone D, Silver D (2002) Abdominal aortic sarcoma: report of a case with long term survival and a review of the literature. Ann Vasc Surg 16(5): 545
Simpson WL Jr, Mendelson DS (2000) Pilmonary artery and aortic sarcomas: cross-sectional imaging. J Thorac Imaging 15(4): 290
Sladden R (1964) Neoplasia of the aortic intima. J Clin Pathol 17: 602
Smeloff E, Reece J, Maters J (1965) Primary malignant tumor of the aorta. Am J Cardiol 15: 107
Steckmeier B (2001) Epidemiologie der Aortenerkrankung: Aneurysma, Dissektion, Verschluss. Radiologe 41(8): 624
Steffelaar JW, van der Heul RO, Blackstone E, Vos A (1975) Primary sarcoma of the aorta. Arch Pathol 99(3): 139
Steinberg JB, Johnson ER, Benda JA, Lanza LA (1993) Primary leiomyosarkoma of the thoracic aorta presenting as a contained rupture. Ann Thorac Surg 56(6): 1387
Stevenson JE, Burkhead H, Trueheart RE, McLaren J (1971) Primary malignant tumor of the aorta. Am J Med 51(4): 553
Suzuki M, Shimoda T, Ushigome S, Aizawa S (1989) Leiomyosarkoma of the thoracic aorta with dissecting aneurysm. Acta Pathol Jpn 39(5): 336
Szekely E, Kulka J, Miklos I, Kaliszky P (2000) Leiomyosarcomas of the great vessels. Pathol Oncol Res 6(3): 233
Tajeda E, Becker GJ, Waller BF (1991) Malignant myxoid emboli as the presenting feature of primary sarcoma of the aorta (myxoid malignant fibrous histiocytoma): a case report and review of the literature. Clin Cardiol 14(5): 425
Talard P, Lemmens B, Duval JL, Dubayle P, Bouchiat C, Carloz E (1992) Angiosarcoma of the aorta disclosed by intestinal metastases. Arch Mal Coeur Vaiss 85(5): 453
Testini M, Todisco C, Simone M et al. (1996) Treatment of haemorrhage following rupture of aortic leiomyosarcoma. Survival for 4.2 years. J Cardiovasc Surg 37(6): 593
Weinberg DS, Maini BS (1980) Primary sarcoma of the aorta associated with vascular prosthesis: a case report. Cancer 46(2): 398
Weiss WM, Riles ST, Gouge TH, Mizrachi HH (1991) Angiosarcoma at the site of a Dacron vascular prothesis: a case report and literature review. J Vasc Surg 14(1): 87
Winkelmann RK, van Heerden JA, Bernatz PE (1971) Malignant vascular endothelial tumor with distal embolization. Am J Med 51: 692
Wright EP, Glick AD, Virmani R, Page DL (1985) Aortic intimal sarcoma with embolic metastases. Am J Surg Pathol 9(12): 890
Yasuda T, Yamamoto S, Yamaguchi S, Ishida Y (1999) Leiomyosarcoma of the thoracic aorta. Jpn J Thorac Cardiovasc Surg 47(10): 510
Zeitlhofer J, Holzner JH, Krepler P (1963) Primates Fibromyosarkom der Aorta. Krebsarzt 18: 259
Interessenkonflikt:
Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Osei-Agyemang, T., Geks, J., Wagner, HJ. et al. Hochmalignes Intimasarkom in einem Aneurysma der infrarenalen Bauchaorta. Chirurg 75, 823–827 (2004). https://doi.org/10.1007/s00104-004-0830-z
Issue Date:
DOI: https://doi.org/10.1007/s00104-004-0830-z