Abstract
The association between microRNA polymorphisms (miR polymorphisms) and coronary heart disease (CHD) risk has been studied intensively, but the results have been conflicting. Therefore, we conducted the present meta-analysis to obtain a more conclusive answer. We searched for eligible articles in PubMed, MEDLINE, EMBASE, Scopus, and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to identify any potential associations. Ten case-control studies including 5,292 CHD patients and 5,446 control subjects were analyzed. The overall meta-analysis results showed that the miR-146a rs2910164 polymorphism, the miR-196a2 rs11614913 polymorphism, and the miR-499 rs3746444 polymorphism were all significantly associated with CHD risk in certain genetic models. Besides, the C allele of the miR-146a rs2910164 and miR-499 rs3746444 polymorphisms conferred increased susceptibility to CHD (C versus G, p < 0.0001, OR = 1.14, 95% CI = 1.07–1.21; p = 0.003, OR = 1.14, 95% CI = 1.05–1.25). Overall, our findings suggest that the miR-146a rs2910164, miR-196a2 rs11614913, and miR-499 rs3746444 polymorphisms may be correlated with the risk of CHD.
Zusammenfassung
Der Zusammenhang zwischen microRNA(miR)-Polymorphismen und dem Risiko einer koronaren Herzkrankheit (KHK) wurde zwar intensiv untersucht – jedoch mit widersprüchlichen Ergebnissen. Um ein schlüssigeres Ergebnis zu erhalten, führten die Autoren daher die vorliegende Metaanalyse durch. Geeignete Artikel wurden in den Datenbanken PubMed, MEDLINE, EMBASE, Scopus und China National Knowledge Infrastructure (CNKI) gesucht. Die Odds Ratio (OR) und das 95 %-Konfidenzintervall (95 %-KI) wurden verwendet, um mögliche Verbindungen zwischen miR-Polymorphismen und dem Risiko einer KHK zu erkennen. Dazu wurden 10 Fall-Kontroll-Studien mit 5292 KHK-Patienten und 5446 Kontrollpersonen analysiert. Insgesamt zeigten die Ergebnisse der Metaanalyse, dass die Polymorphismen miR-146a rs2910164, miR-196a2 rs11614913 und miR-499 rs3746444 in bestimmten genetischen Modellen signifikant mit dem Risiko einer KHK assoziiert waren. Das C‑Allel des Polymorphismus miR-146a rs2910164 und des Polymorphismus miR-499 rs3746444 führte zu einer erhöhten Anfälligkeit für KHK (C gegen G, p < 0,0001; OR = 1,14; 95 %-KI: 1,07–1,21; p = 0,003; OR = 1,14; 95 %-KI: 1,05–1,25). Die vorliegenden Ergebnisse deuten darauf hin, dass die Polymorphismen miR-146a rs2910164, miR-196a2 rs11614913 und miR-499 rs3746444 möglicherweise mit dem Risiko einer KHK korrelieren.
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This work was supported by grants from the National Natural Science Foundation of China (81270289, 81300169).
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X. Xie, X. Shi, X. Xun, and L. Rao declare that they have no competing interests.
This article does not contain any studies with human participants or animals performed by any of the authors.
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Xie, X., Shi, X., Xun, X. et al. Association between microRNA polymorphisms and coronary heart disease. Herz 42, 593–603 (2017). https://doi.org/10.1007/s00059-016-4495-4
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DOI: https://doi.org/10.1007/s00059-016-4495-4