Abstract
A new interesting family of 2,5-dialkyloxazolopyrano[3,2-c]quinolinone derivatives 4a-l were synthesized in good yields using a convenient and successful method. Structures of all compounds were achieved by elemental analyses, IR, 1H NMR, 13C NMR, and mass techniques. The tetracyclic homologues 4a-l were evaluated for antitumor activity and cytotoxicity against a board of three human cancer cell lines (HepG-2, MCF-7, and HCT-116). The cells were treated with these compounds at differentiable dosages, and cell viability was determined. Significant anticancer activities were observed in vitro for some members of the series related to 5-fluorouracil and compounds 4c and 4f showed potent cytotoxic effect, that creates these compounds were disclosed as the most applicable anticancer agents against different cancer cell lines.
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This work was accomplished under national funding from General Administration of Environment Projects, Ain Shams University.
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Hassanin, H.M., Abd Elmoneam, W.R. & Mostafa, M.A. Synthesis and antitumor activity evaluation of different 2,5-dialkyloxazolopyrano[3,2-c]quinolinone derivatives. Med Chem Res 28, 28–38 (2019). https://doi.org/10.1007/s00044-018-2259-9
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DOI: https://doi.org/10.1007/s00044-018-2259-9