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Synthesis and antimicrobial activity of 3-aroyl-4-heteroaryl pyrroles and pyrazoles

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Abstract

A variety of bis heterocycles-heteroaryl pyrazoles (5) and pyrroles (6) were prepared from heteroaryl chalcones adopting 1,3-dipolar cycloaddition reaction and studied their antimicrobial activity. The compounds 5d and 5f having bromo and nitro substituents on the aromatic ring are the potent antimicrobial agents against Bacillus subtilis and Aspergillus niger.

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Acknowledgments

One of the authors V. Padmavathi is grateful to Council of Scientific and Industrial Research (CSIR), New Delhi for financial assistance under major research project. One of the authors P. Ramachandra Reddy is thankful to Council of Scientific and Industrial Research (CSIR), New Delhi, India for the sanction of Senior Research Fellowship (SRF).

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Authors and Affiliations

  1. Department of Chemistry, Sri Venkateswara University, Tirupati, 517 502, Andhra Pradesh, India

    Shaik Sharafuddin Basha, Putta Ramachandra Reddy, Adivireddy Padmaja & Venkatapuram Padmavathi

  2. Department of Botany, Sri Venkateswara University, Tirupati, 517 502, Andhra Pradesh, India

    Kalla Chandra Mouli & Tartte Vijaya

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  1. Shaik Sharafuddin Basha
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  2. Putta Ramachandra Reddy
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  3. Adivireddy Padmaja
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  4. Venkatapuram Padmavathi
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  5. Kalla Chandra Mouli
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  6. Tartte Vijaya
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Correspondence to Venkatapuram Padmavathi.

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Basha, S.S., Ramachandra Reddy, P., Padmaja, A. et al. Synthesis and antimicrobial activity of 3-aroyl-4-heteroaryl pyrroles and pyrazoles. Med Chem Res 24, 954–964 (2015). https://doi.org/10.1007/s00044-014-1169-8

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  • DOI: https://doi.org/10.1007/s00044-014-1169-8

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