Abstract
A new series of pyrrolyl carboxamides, pyrrolyl sulfonamides, and pyrrolyl pyrimidine derivatives were prepared from simple starting compounds—ethyl 3-phenylacrylate and ethyl 3-furanylacrylate under ultrasonication and screened for their antimicrobial activity. Among the tested compounds pyrrolyl pyrimidine derivatives and chloro-substituted pyrroles displayed excellent activity when compared to the other compounds. The chloro-substituted pyrrolyl sulfonamides are the potent antimicrobial agents particularly against P. aeruginosa and P. chrysogenum.
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One of the authors A. Padmaja is grateful to CSIR, New Delhi, India for financial assistance under major research project. The authors are also thankful to Prof. D. V. R. Sai Gopal, Department of Bio-Chemistry (SVU), for Biological Activity.
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Syamaiah, K., Mallikarjuna Reddy, G., Padmavathi, V. et al. Synthesis and antimicrobial activity of some new amido/sulfonamido-linked 3,4-disubstituted pyrroles. Med Chem Res 23, 3287–3297 (2014). https://doi.org/10.1007/s00044-014-0908-1
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DOI: https://doi.org/10.1007/s00044-014-0908-1