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Synthesis and antimicrobial activity of morpholinyl/piperazinylbenzothiazines

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Abstract

Structurally diverse morpholinyl/piperazinylbenzothiazines have been synthesized in quantitative yields by the reaction of substituted 1,4-benzothiazines with morpholine/N-(2-hydroxyethyl)piperazine. 1,4-Benzothiazines were prepared by the reaction of substituted 2-aminobenzenethiols with β-ketoesters. The structures of the synthesized compounds were confirmed by their analytical and spectroscopic data. The synthesized compounds were evaluated for their antimicrobial activity against bacterial species; E. coli and Bacillus cereus. Some of the synthesized compounds have shown significant activity against microorganisms.

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Acknowledgments

The authors are thankful to the Head, Department of Chemistry, University of Rajasthan, Jaipur (India) for providing necessary laboratory facilities as well as instrumentation facilities (IR, 1HNMR and 13C NMR). We express our thanks to UGC, New Delhi, for providing Meritorious Student Fellowship to one of the authors (P.K.S.).

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Authors and Affiliations

  1. Department of Chemistry, University of Rajasthan, Jaipur, 302055, India

    Praveen Kumar Sharma & M. Kumar

  2. Department of Botany, University of Rajasthan, Jaipur, 302055, India

    Sharad Vats

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  1. Praveen Kumar Sharma
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  2. M. Kumar
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Correspondence to M. Kumar.

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Sharma, P.K., Kumar, M. & Vats, S. Synthesis and antimicrobial activity of morpholinyl/piperazinylbenzothiazines. Med Chem Res 21, 2072–2078 (2012). https://doi.org/10.1007/s00044-011-9732-z

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  • DOI: https://doi.org/10.1007/s00044-011-9732-z

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