Abstract
A series of oxazole and pyrazole derivatives of pongamol (1) were designed and synthesized to examine their anti-cancer activity. The cytotoxicity of these compounds was examined in three different human tumor cell lines, IMR-32, HeLa and Jurkat. Although all compounds tested were quite effective than the pongamol against all the three different types of cancer cell lines examined, the compounds (2), (5), and (6) were found to be the most active compounds of this series.
Graphical abstract
A series of pongamol derivatives (2–13) (oxazole and Pyrazole derivatives) have been synthesized and tested for their anti-cancer properties against the three human tumor cell lines (IMR32, HeLa, and jurkat).
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Acknowledgments
Authors gratefully acknowledge keen interest of Dr. J. S. Yadav, Director, IICT, Hyderabad. RRR thanks to CSIR, New Delhi for his financial support.
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Rao, R.R., Chaturvedi, V., Babu, K.S. et al. Synthesis and anticancer effects of pongamol derivatives on mitogen signaling and cell cycle kinases. Med Chem Res 21, 634–641 (2012). https://doi.org/10.1007/s00044-011-9563-y
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DOI: https://doi.org/10.1007/s00044-011-9563-y