Abstract
Cu and Ag–Cu mixed alloy nanoparticles displayed significant inhibition to HIV-1 replication with limited toxicity to human cells at relatively low concentrations of metal. A previous study (Elechiguerra et al. in J Nanobiotechnol 3:6–16, 2005) suggested a size-specific Ag nanoparticle can be tailored to block or damage the glycoprotein (gp) 120/gp41 spike or, more specifically, the invariant epitope at the gp120 binding site. Two different protocols were employed to test whether nanoparticles block entry of HIV-1, and in both instances the nanoparticles acted at some point other than initial binding. This work shows that Ag, Cu, and Ag–Cu mixed alloy metals display a chemically dependent inactivation of the target virus.
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This research was supported by the Office of Naval Research.
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Michael A. Mastro and Andrew W. Hardy contributed equally to this work.
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Mastro, M.A., Hardy, A.W., Boasso, A. et al. Non-toxic inhibition of HIV-1 replication with silver–copper nanoparticles. Med Chem Res 19, 1074–1081 (2010). https://doi.org/10.1007/s00044-009-9253-1
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DOI: https://doi.org/10.1007/s00044-009-9253-1