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Microbiota-assisted therapy for systemic inflammatory arthritis: advances and mechanistic insights

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Abstract

Research on the influence of gut microbiota on systemic inflammatory arthritis has exploded in the past decade. Gut microbiota changes may be a crucial regulatory component in systemic inflammatory arthritis. As a result of advancements in the field, microbiota-assisted therapy has evolved, but this discipline is still in its infancy. Consequently, we review the limitations of current systemic inflammatory arthritis treatment, analyze the connection between the microbiota and arthritis, and summarize the research progress of microbiota regulating systemic inflammatory arthritis and the further development aspects of microbiota-assisted therapy. Finally, the partial mechanisms of microbiota-assisted therapy of systemic inflammatory arthritis are being discussed. In general, this review summarizes the current progress, challenges, and prospects of microbiota-assisted therapy for systemic inflammatory arthritis and points out the direction for the development of microbiota-assisted therapy in the future.

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The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

This research was supported by the National Natural Science Foundation of China (Nos. 32021005, 31820103010), and the Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province.

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Authors and Affiliations

  1. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China

    Bowen Li, Bo Yang, Xiaoming Liu, Jianxin Zhao, Hao Zhang & Wei Chen

  2. School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, China

    Bowen Li, Bo Yang, Xiaoming Liu, Jianxin Zhao, Hao Zhang & Wei Chen

  3. International Joint Research Center for Probiotics and Gut Health, Jiangnan University, Wuxi, Jiangsu, China

    Bo Yang, Xiaoming Liu, Jianxin Zhao, R. Paul Ross & Catherine Stanton

  4. APC Microbiome Ireland, University College Cork, Cork, Ireland

    R. Paul Ross & Catherine Stanton

  5. Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland

    Catherine Stanton

  6. National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu, China

    Hao Zhang & Wei Chen

  7. Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, Wuxi, China

    Hao Zhang

  8. Beijing Innovation Center of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing, China

    Wei Chen

Authors
  1. Bowen Li
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  2. Bo Yang
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  3. Xiaoming Liu
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  4. Jianxin Zhao
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  5. R. Paul Ross
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  6. Catherine Stanton
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  7. Hao Zhang
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  8. Wei Chen
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Contributions

WC and BY supervised the study. RPR, CS and HZ participated in the design and discussion of the research. BL, BY, XL, JZ, RPR, CS, HZ, and WC contributed to the analysis, and interpretation for the work. BL drafted manuscript. BY, RPR and WC revised the manuscript and all authors have read and approved final interpretation for the work.

Corresponding authors

Correspondence to Bo Yang, R. Paul Ross or Wei Chen.

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Li, B., Yang, B., Liu, X. et al. Microbiota-assisted therapy for systemic inflammatory arthritis: advances and mechanistic insights. Cell. Mol. Life Sci. 79, 470 (2022). https://doi.org/10.1007/s00018-022-04498-6

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