Abstract
The adult brain most probably reaches its highest degree of plasticity with the lifelong generation and integration of new neurons in the hippocampus and olfactory system. Neural precursor cells (NPCs) residing both in the subgranular zone of the dentate gyrus and in the subventricular zone of the lateral ventricles continuously generate neurons that populate the dentate gyrus and the olfactory bulb, respectively. The regulation of NPC proliferation in the adult brain has been widely investigated in the past few years. Yet, the intrinsic cell cycle machinery underlying NPC proliferation remains largely unexplored. In this review, we discuss the cell cycle components that are involved in the regulation of NPC proliferation in both neurogenic areas of the adult brain.

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Acknowledgments
This work was supported by the Fonds Léon Frédéricq (FLF) and the Fondation Médicale Reine Elisabeth. PB was supported by the FLF and a concerted action of the French Community of Belgium (Convention no. 04/09-322). RV is supported by a postdoctoral fellowship from the Alzheimer Society of Canada. NC is a research fellow of the Fonds pour la formation à la Recherche dans l’Industrie et dans l’Agriculture (FRIA). LN and BM are respectively research associate and research director of the Belgian Fonds National de la Recherche Scientifique (FNRS).
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P. Beukelaers and R. Vandenbosch contributed equally to this work.
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Beukelaers, P., Vandenbosch, R., Caron, N. et al. Cycling or not cycling: cell cycle regulatory molecules and adult neurogenesis. Cell. Mol. Life Sci. 69, 1493–1503 (2012). https://doi.org/10.1007/s00018-011-0880-6
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DOI: https://doi.org/10.1007/s00018-011-0880-6
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