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Structural determinants of protein folding

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Abstract

The last several decades have seen an explosion of knowledge in the field of structural biology. With critical advances in spectroscopic techniques in examining structures of biomacromolecules, in maturation of molecular biology techniques, as well as vast improvements in computation prowess, protein structures are now being elucidated at an unprecedented rate. In spite of all the recent advances, the protein folding puzzle remains as one of the fundamental biochemical challenges. A facet to this empiric problem is the structural determinants of protein folding. What are the driving forces that pivot a polypeptide chain to a specific conformation amongst the vast conformation space? In this review, we shall discuss some of the structural determinants to protein folding that have been identified in the recent decades.

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Acknowledgement

Tse Siang Kang is supported by the National University of Singapore under the Overseas Postdoctoral Fellowship.

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  1. The Scripps Research Institute, 10550 North Torrey Pines Road GAC 1200, La Jolla, CA, 92037, USA

    Tse Siang Kang

  2. Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Block S4, Singapore, 117543, Singapore

    Tse Siang Kang

  3. Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Block S3 #03-17, Singapore, 117543, Singapore

    R. Manjunatha Kini

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Kang, T.S., Kini, R.M. Structural determinants of protein folding. Cell. Mol. Life Sci. 66, 2341–2361 (2009). https://doi.org/10.1007/s00018-009-0023-5

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