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Tandem asymmetric C-C bond formations by enzyme catalysis

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Glycoscience Synthesis of Oligosaccharides and Glycoconjugates

Part of the book series: Topics in Current Chemistry ((4143,volume 186))

Abstract

Catalytic aldol reactions are among the most useful synthetic methods for highly stereocontrolled asymmetric synthesis. In this account we discuss the recent development of a novel synthetic technique which uses tandem enzyme catalysis for the bi-directional chain elongation of simple dialdehydes and related multi-step procedures. The scope and the limitations of multiple one-pot enzymatic C-C bond formations is evaluated for the synthesis of unique and structurally complex carbohydrate-related compounds that may be regarded as metabolically stable mimetics of oligosaccharides and that are thus of interest because of their potential bioactivity.

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  1. Institut für Organische Chemie der Rheinisch-Westfälischen Technischen Hochschule Aachen, Professor-Pirlet-Str. 1, D-52056, Aachen, Germany

    Michael Petersen, Maria Teresa Zannetti & Wolf-Dieter Fessner

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  1. Michael Petersen
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  2. Maria Teresa Zannetti
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  3. Wolf-Dieter Fessner
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Hugues Driguez Joachim Thiem

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Petersen, M., Zannetti, M.T., Fessner, WD. (1997). Tandem asymmetric C-C bond formations by enzyme catalysis. In: Driguez, H., Thiem, J. (eds) Glycoscience Synthesis of Oligosaccharides and Glycoconjugates. Topics in Current Chemistry, vol 186. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0119221

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  • DOI: https://doi.org/10.1007/BFb0119221

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