Skip to main content
Log in

When genotype prevails: sexual female-to-male transformation in Classical Antiquity, recorded by Gaius Plinius Secundus and Phlegon

  • Historical Note
  • Published:
Hormones Aims and scope Submit manuscript

Abstract

Cases of sexual reassignment in classical antiquity, namely a female-to-male gender change occurring after childhood, are described in the literature. Textual evidence concerning these cases of androgynism and their symbolism as well as a comprehensive scholar analysis is provided in the present study. Medical interpretation of these cases covers the entire spectrum of differential diagnosis of heterosexual puberty in pseudohermaphrodites characterized by genital ambiguity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Pliny the Elder, Historia Naturalis VII 36, Collection des Universités de France.

  2. Keller O, 1877 Rerum naturalium scriptores graeci minores. Publisher: In aedibus B.G. Teubneri.

  3. Kousta E, Papathanasiou A, Skordis N, 2010 Sex determination and disorders of sex development according to the revised nomenclature and classification in 46,XX individuals. Hormones (Athens) 3: 218–131.

    Article  Google Scholar 

  4. George MM, New MI, Ten S, Sultan C, Bhangoo A, 2010 The clinical and molecular heterogeneity of 17βHSD-3 enzyme deficiency. Horm Res Paediatr 74: 229–240.

    Article  CAS  PubMed  Google Scholar 

  5. Hoppe U, Holterhus PM, Wunsch L, et al, 2006 Tissue-specific transcription profiles of sex steroid biosynthesis enzymes and the androgen receptor. J Mol Med 84: 651–659.

    Article  CAS  PubMed  Google Scholar 

  6. Thiele S, Hoppe U, Holterhus PM, Hiort O, 2005 Isoenzyme type 1 of 5alpha-reductase is abundantly transcribed in normal human genital skin fibroblasts and may play an important role in masculinization of 5alpha-reductase type 2 deficient males. Eur J Endocrinol 152: 875–880.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Neoklis A. Georgopoulos.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Armeni, A.K., Vasileiou, V. & Georgopoulos, N.A. When genotype prevails: sexual female-to-male transformation in Classical Antiquity, recorded by Gaius Plinius Secundus and Phlegon. Hormones 13, 153–156 (2014). https://doi.org/10.1007/BF03401331

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03401331

Key words

Navigation