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Cancer mortality trends in two cohorts of elderly people having different life-styles

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Abstract

We analyzed cancer mortality trends in 3282 elderly subjects from two general Italian populations with different life-style patterns taking part in the Cardiovascular Study in the Elderly (CASTEL). The aim of the study was to evaluate which predictors were able to influence cancer mortality. Age, gender, tobacco smoking, the presence of respiratory symptoms, increased serum levels of ALT and ALP, and the town of residence were powerful predictors. Subjects living in Chiog-gia (low income, rural) had significantly greater lung and liver cancer mortality, compared with those living in Castelfranco (industrial). The findings suggest that an incongruous life-style (smoking, alcohol consumption, poor hygienic conditions) may increase cancer mortality despite the favorable environmental conditions typical of rural Mediterranean areas.

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References

  1. Ebrahim S.: Public health implications of ageing. J. Royal Coll. Phys. 29: 207–215, 1995.

    CAS  Google Scholar 

  2. Manton K.G., Stallard E., Liu K.: Forecast of active life ex-pectancy: policy and fiscal implications. J. Gerontol. 48: 11–26, 1993.

    Article  PubMed  Google Scholar 

  3. Sallar A.M., Hogg R.S., Schechter M.T.: Survival after age 80. N. Engl. J. Med. 334: 537–538, 1996.

    Article  CAS  PubMed  Google Scholar 

  4. Rosenwaike I., Logue B.: Accuracy of death certificate ages for the extreme aged. Demography 20: 569–585, 1983.

    Article  Google Scholar 

  5. World Health Statistics Annual, 1993. World Health Organization, Geneva, 1994.

    Google Scholar 

  6. Kannisto A.U.: Development of oldest-old mortality, 1950–1990: evidence from 28 developed countries. Odense University Press, Odense, Denmark, 1994.

    Google Scholar 

  7. Manton K.G., Vaupel J.W.: Survival after the age of 80 in the United States, Sweden, France, England, and Japan. N. Engl. J. Med. 333: 1232–1235, 1995.

    Article  CAS  PubMed  Google Scholar 

  8. Kohn R.R. Cause of death in very old people. JAMA 247: 2793–2797, 1982.

    Article  CAS  PubMed  Google Scholar 

  9. Kaplan G.A., Seeman T.E., Cohen R.D., Knudsen L.P., Guralnik J.: Mortality among the elderly in Alameda County Study: behavioural and demographic risk factors. Am. J. Public Health 77: 303–312, 1987.

    Article  Google Scholar 

  10. Lee D.J., Mrakides K.S.: Activity and mortality among aged persons over an eight-year period. J. Gerontol. 45: 39–42, 1990.

    Article  Google Scholar 

  11. Yancik R., Ries L.A.: Cancer in older persons. Magnitude of the problem–how do we apply what we know? Cancer 74: 1995–2003, 1994.

    Article  CAS  PubMed  Google Scholar 

  12. Casiglia E., Spolaore P., Ginocchio G., Colangeli G., Di Menza G., Marchioro M., Mazza A., Ambrosio G.B.: Predictors mortality in very old subjects aged 80 years or over. Eur. J. Epidemiol. 9: 577–586, 1993.

    Article  CAS  PubMed  Google Scholar 

  13. Levi F., La Vecchia C., Lucchini F., Negri E.: Worldwide trends in cancer mortality in the elderly, 1955–1992. Eur. J. Cancer 32: 652–672, 1996.

    Article  Google Scholar 

  14. Miller R.A.: Gerontology as Oncology. Research of aging as the key to the understanding of cancer. Cancer 68: 2496–2501, 1991.

    Article  CAS  PubMed  Google Scholar 

  15. Newell G.R., Spitz M.R., Sider J.G.: Cancer and age. Semin. Oncol. 16: 3–9, 1989.

    CAS  PubMed  Google Scholar 

  16. Hoel D.G., Davis D.L., Miller A.B., Sondik E.J., Swerdlow A.J.: Trends in cancer mortality in 15 industrialized countries, 1969–1986. J. Natl.Cancer Inst. 84: 313–320, 1992.

    Article  CAS  PubMed  Google Scholar 

  17. Smith D.W.E.: Cancer mortality at very old ages. Cancer 77: 1367–1372, 1996.

    Article  CAS  PubMed  Google Scholar 

  18. Miles T.P., Bernard M.A.: Morbidity, disability and health status of black American elderly: a new look at the oldest-old. J. Am. Geriatr. Soc. 40: 1047–1054, 1992.

    Article  CAS  PubMed  Google Scholar 

  19. Ruigómez A., Alonso J., Antó M.J.: Relationship of health behaviours to five-years mortality in an elderly cohort. Age Ageing 24: 113–119, 1995.

    Article  PubMed  Google Scholar 

  20. Higginson J.: Environmental carcinogenesis. Cancer 72: 971–977, 1993.

    Article  CAS  PubMed  Google Scholar 

  21. Peto R., Row F.J.C., Lee P.N., Levy L., Clack J.: Cancer and aging in mice and men. Br. J. Cancer 32: 411–426, 1975.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Kaesberg P.R., Ershler W.B.: The importance of immunose-nescence in the incidence and malignant properties of cancer in hosts of advances age. J. Gerontoi. 44: 63–66, 1989.

    Article  CAS  Google Scholar 

  23. Kaesberg P.R., Ershler W.B.: The change in tumor aggres-siveness with age: lessons from experimental animals. Semin. Oncol. 16: 28–33, 1989.

    CAS  PubMed  Google Scholar 

  24. Casiglia E., Spolaore P., Mormino P., Maschio O., Colangeli G., Celegon L., Tittoto L., Pasinato A., Ambrosio G.B.: The CAS-TEL project (CArdiovascular STudy in the ELderly): protocol, study design and preliminary results of the initial screening. Cardiologia 36: 569–576, 1991.

    CAS  PubMed  Google Scholar 

  25. Casiglia E., Spolaore P., Ginocchio G., Colangeli G., Maschio O., Marchioro M., Lanzieri M., Ambrosio G.B.: Proteinuria predicts mortality among elderly but not among “very older” subjects. J. Nephrol. 5: 89–93, 1992.

    Google Scholar 

  26. Descovich G.C., Dalmonte G., Dormi A., Braiato A., Mannino G., Benassi M.S., Gaddi A., Sangiorgi Z., Trivelli N., Lenzi S.: The Brisighella Study: a community survey. In: Lenzi S., Descovich G.C. (Eds.), Atherosclerosis and cardiovascular disease. MPT Press, Norwell MA, USA, 1987. pp. 215–222.

    Chapter  Google Scholar 

  27. Zanetti G., Colussi P., Pagnan A., Dal Palù C.: Comporta-mento delia colesterolemia totale nei pazienti affetti da neo-plasie maligne: studio epidemiologico trasversale. Giorn. Arterioscl. 15: 85–90, 1990.

    Google Scholar 

  28. Rose G.A., Blackburn H., Gillum R.F., Prineas R.J.: Cardiovascular survey methods. World Health Organization, Geneva, 1982.

    Google Scholar 

  29. Tietz N.W., Shuey D.F., Huang W.Y., Rauh D.F., Shuey D.F.: Laboratory tests in the differential diagnosis of hyper-amylasemia. Clin. Chem. 32: 301–317, 1986.

    CAS  PubMed  Google Scholar 

  30. Colton T., Buxbaum R.C.: Motor vehicle inspection and motor vehicle accident mortality. Am. J. Public Health 58: 1090, 1968.

    Article  CAS  Google Scholar 

  31. Cox D.R.: Regression models and life tables. J. R. Stat. Soc. 34, Series B, 1972. pp. 187–220.

    Google Scholar 

  32. Cox D.R., Oakes D.: Analysis of survival data. Chapman and Hall, London, 1984.

    Google Scholar 

  33. Lopez A.D.: Competing causes of death. A review of recent trends in mortality in industrialized countries with special reference to cancer. Ann. N.Y. Acad. Sci. 609: 58–76, 1990.

    Article  CAS  PubMed  Google Scholar 

  34. Muirs C.S.: Epidemiology, basic science and the prevention of cancer: implications for the future. Cancer Res. 50: 6441–6448, 1990.

    Google Scholar 

  35. Yancik R., Ries G.L.: Cancer in the aged. An epidemiologic perspective on treatment issues. Cancer 68: 2502–2510, 1991.

    Article  CAS  PubMed  Google Scholar 

  36. Doll R., Peto R.: The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. Oxford University Press, New York, 1981.

    Google Scholar 

  37. Byers T., Perry G.: Dietary carotenes, vitamin C and vitamin E as prospective antioxidants human cancers. Annu. Rev. Nutr. 12:139–159, 1992.

    Article  CAS  PubMed  Google Scholar 

  38. Simopoulos A.P.: Nutritional cancer risks derived from energy and fat. Med. Oncol. Tumor Pharm. 4: 227–239, 1987.

    CAS  Google Scholar 

  39. Boyle P., Veronesi U., Tubiana M., Alexander F.E., Calais da Silva F., Denis L.J., Freire J.M., Hakama M., Hirsch A., Kroes R., La Vecchia C., Maisonneuve P., Martin-Moreno J.M., Newton-Bishop J., Pindborg J.J., Saracci R., Scully C., Standaert B., Storm H., Blanco S., Malbois R., Bleehen N., Dicato M., Plesnicar S.: European School of Oncology advisory report to the European commission for the “Europe Against Cancer Programme”, European Code Against Cancer. Eur. J. Cancer 31: 1395–1405, 1995.

    Article  Google Scholar 

  40. Austoker J.: Cancer prevention in primary care. Cancer prevention: setting the scene. BMJ 308: 1415–1420, 1994.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Kanstrom L., Holm L.E.: Promoting dietary change in the Stockholm cancer prevention program. Cancer Detect. Prev. 16: 203–210, 1992.

    CAS  PubMed  Google Scholar 

  42. Peto R., Lopez A.D., Boreham J., Thun M., Heath C. Jr.: Mortality from tobacco in developed countries: indirect estimation from national vital statistics. Lancet 339: 1268–1278, 1992.

    Article  CAS  PubMed  Google Scholar 

  43. McLaughlin J.K., Hrubec Z., Blot W.J., Fraumeni J.F. Jr.: Smoking and cancer mortality among U.S. veterans: a 26-year follow-up. Int. J. Cancer 60: 190–193, 1995.

    Article  CAS  PubMed  Google Scholar 

  44. Pisani P., Lopez A.D., Masuyer E.: At least one in seven cases of cancer is caused by smoking. Global estimates Parkin for 1985. Int. J. Cancer 59: 494–504, 1994.

    Article  PubMed  Google Scholar 

  45. Sterling T.D., Rosenbaum W.L., Weinkam J.J.: Analysis of the relationship between smokeless tobacco and cancer based on data from the national mortality follow back survey. J. Clin. Epidemiol. 45: 223–231, 1992.

    Article  CAS  PubMed  Google Scholar 

  46. Ronneberg A., Lund K.E., Hafstad A.: Lifetime smoking habits among Norwegian men and women born between 1890 and 1974. Int. J. Epidemiol. 23: 267–276, 1994.

    Article  CAS  PubMed  Google Scholar 

  47. Maier H., Dietz A., Gewelke U., Heller W.D., Weidauer R.: Tobacco and alcohol and the risk of head and neck cancer. Clin. Invest. 70: 320–327, 1992.

    CAS  Google Scholar 

  48. Rabat G.C., Chang C.J., Wynder E.L.: The role of tobacco, alcohol use, and body mass index in oral and pharyngeal cancer. Int. J. Epidemiol. 23: 1137–1144, 1994.

    Article  Google Scholar 

  49. Mastrangelo G., Malusa E., Veronese C., Zucchero A., Marzia A., Boscolo Bariga A.: Mortality from lung cancer and other diseases related to smoking among fishermen in Northeast Italy. Occup. Environ. Med. 52: 150–153, 1995.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Reizenstein P., Modan B., Kuller L.H.: The quandary of cancer prevention. J. Clin. Epidemiol. 47: 575–581, 1994.

    Article  CAS  PubMed  Google Scholar 

  51. Vainio R, Matos E., Boffetta P., Kogevinas M., Wilbourn J.: Occupational cancer in developing and new industrialized countries. Ann. Acad. Med. Singapore 22: 170–181, 1993.

    CAS  PubMed  Google Scholar 

  52. Doll R.: Are we winning the fight against cancer? An epi-demiological assessment. EARC- Muhlbock Memorial Lecture. Eur. J. Cancer 25: 500–508, 1990.

    Article  Google Scholar 

  53. Doll R.: Progress against cancer: An epidemiological assessment. The 1991 John C. Cassell Memorial Lecture. Am. J. Epidemiol. 134: 675–688, 1991.

    Article  CAS  PubMed  Google Scholar 

  54. La Vecchia C., Negri E., Decarli A., Fasoli M., Cislaghi C.: Cancer mortality in Italy: an overview of age-specific and age-standardised trends from 1955 to 1984. Tumori 76: 87–166, 1990.

    Article  PubMed  Google Scholar 

  55. Francescon A., Gessoni G., Manoni F., Scarpa R.: Infezione da virus C nell’anziano: studio sierologico e valutazione dei fat-tori di rischio. Giorn. Geront. 43: 145–151, 1995.

    Google Scholar 

  56. Gessoni G., Manoni F.: Prevalence of anti-hepatitis C virus antibodies among teenagers in the Venetian area: a siero-epi-demiological study. Eur. J. Med. 2: 79–82, 1993.

    CAS  PubMed  Google Scholar 

  57. Gessoni G., Manoni F., Prosperi A., Sanavio C., Tedeschi P., Francescon A., Longo L., Giordano R.: L’infezione da HCV: importanza come fattore di rischio nel carcinoma epatocellulare. Giorn. Ven. Sci. Med. 45: 71–76, 1993.

    Google Scholar 

  58. Reuben D.B., Mor V.: Dyspnea in terminally cancer patients. Chest 89: 234–236, 1986.

    Article  CAS  PubMed  Google Scholar 

  59. Escalante C.P., Martin C.G., Elting L.S.: Dyspnea in cancer patients. Etiology, resource utilization, and survival implications in a managed care world. Cancer 78: 1314–1319, 1996.

    Article  CAS  PubMed  Google Scholar 

  60. Hiatt R.A., Fireman B.H.: Serum uric acid unrelated to cancer incidence in humans. Cancer Res. 48: 2916–2918, 1988.

    CAS  PubMed  Google Scholar 

  61. Levine W., Dyer A.R., Shekelle R.B, Schoenberger J.A., Stamler J.: Serum uric acid and 11.5 years mortality of middle-aged women: findings of the Chicago Heart Association Detection Project in Industry. J. Clin. Epidemiol. 42: 257–267, 1989.

    Article  CAS  PubMed  Google Scholar 

  62. Rustin G.J.: Circulating tumour markers in the management of human cancer. In: Daar A.S. (Ed.), Tumour Markers in Clinical Practice: Concepts and Applications. Blackwell, Oxford, UK, 1987. pp. 204–227.

    Google Scholar 

  63. Fishman W.H.: The 1993 ISOBM Abbott Award Lecture. Isoenzymes, tumour markers and oncodevelopmental biology. Tumour Biol. 16: 394–402, 1995.

    Article  CAS  PubMed  Google Scholar 

  64. Wolf P.L.: Clinical significance of increased or decreased serum alkaline phosphatase isoenzymes. Clin. Lab. Med. 6: 525–532, 1986.

    CAS  PubMed  Google Scholar 

  65. Borghi L., Alberti A., Zocca A.: La frazione biliare delia AP nelle neoplasie epatiche. G. Clin. Med. 63: 271–273, 1986.

    Google Scholar 

  66. Bacci P., Picci P., Ferrari S.: Prognostic significance of serum AP in patients with osteosarcoma treated with adjuvant or neoadjuvant chemotherapy. Cancer 11: 1224–1230, 1993.

    Article  Google Scholar 

  67. Millan J.L., Fishman W.H.: Biology of human alkaline phosphatases with special reference to cancer. Cht. Rev. Clin. Lab. Sei. 32: 1–39, 1995.

    Article  CAS  Google Scholar 

  68. Erickson K.L., Hubbard N.E.: Dietary fish oil modulation of macrophage tumoricidal activity. Nutrition 12: S34–S38, 1996.

    CAS  PubMed  Google Scholar 

  69. McCarty M.F.: Fish oil may impede tumour angiogenesis and invasiveness by down-regulating protein kinase C and modulating eicosanoid production. Med. Hypotheses 46: 107–115, 1996.

    Article  CAS  PubMed  Google Scholar 

  70. Li F.P.: Familial cancer syndromes and clusters. Curr. Probl. Cancer 14: 73–114, 1990.

    Article  CAS  PubMed  Google Scholar 

  71. Shields P.G.: Inherited factors and environmental exposures in cancer risk. J. Occup. Med. 35: 34–41, 1993.

    CAS  PubMed  Google Scholar 

  72. Goldgar D.E., Easton D.F., Cannon-Albrigth L.A., Sholnick M.H.: Systematic population-based assessment of cancer risk in first degree relatives of cancer probands. J. Natl. Cancer Inst. 86: 1600–1608, 1994.

    Article  CAS  PubMed  Google Scholar 

  73. Tefre T., Ryberg D., Haugen A.: Human CYP1A1 (cy-tochrome PI450) gene: lack of association between the Msp I restriction fragment length polymorphism and incidence of lung cancer in a Norwegian population. Pharmacogenetics 1: 20–25, 1991.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Clinical and Experimental Medicine, Clinica Medica IV, Laboratory of Epidemiology, University of Padova, 35128, Padova, Italy

    A. Mazza, E. Casiglia M.D., E. Sica, R. Biasin, G. Privato, A. Pizziol & A. C. Pessina

  2. Department of Geriatrics, General Hospital of Chioggia, Venice, Italy

    R. Scarpa

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  1. A. Mazza
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  2. E. Casiglia M.D.
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  3. R. Scarpa
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Mazza, A., Casiglia, E., Scarpa, R. et al. Cancer mortality trends in two cohorts of elderly people having different life-styles. Aging Clin Exp Res 11, 21–29 (1999). https://doi.org/10.1007/BF03399632

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