Abstract
Although galactorrhea and/or enhanced prolactin (PRL) secretion have been reported with a variety of thoracic stimuli, the effect of thoracic stimulation on dynamic prolactin secretion is not clear. A 49-year-old woman with ventilatory muscle weakness from polio presented with galactorrhea, and intermittent hyperprolactinemia but regular menses. The galactorrhea was noted following the use of a new, tight fitting cuirass (thoracic apparatus which assists ventilation). To determine if the new, “tight” cuirass elicited enhanced PRL secretion, and to assess more extensively the effect of such thoracic stimulation on PRL secretion, serum PRL was measured during brief and prolonged stimulation, sleep, and pharmacological manipulation of PRL. Basal PRL was normal (<25 ng/ml) and increased during brief stimulation (1 hour) with the “tight” (137%) and “loose” cuirass (140%). Although the absolute increments were similar, the “tight” cuirass elicited an earlier PRL peak than the “loose” cuirass and the PRL began to decrease while the “tight” cuirass was still functioning. Several hours of thoracic stimulation resulted in a transient rise in PRL and a fall to normal, prestimulatory levels despite persistent stimulation. During this stimulation, PRL did not rise after sleep nor after insulin-induced hypoglycemia despite normal cortisol and GH increments, but the PRL response after TRH was exaggerated. These data suggest that: 1) the intensity of the thoracic stimulation affects the time of onset rather than the magnitude of the PRL response; 2) extended thoracic stimulation results in the development of an adaptive or counter-regulatory response to the stimulus for PRL secretion; 3) the cuirass inhibits a normal CNS-mediated PRL response to other neurogenic stimuli (hypoglycemia and sleep) despite the presence of pituitary lactotropes which exhibit a hyperresponsive PRL response to direct stimulation by TRH.
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References
Kleinberg D.L., Noel G.L., Frantz A.G. Galactorrhea: A study of 235 cases. N. Engl. J. Med. 296: 589, 1977.
Salkin D., Davis E.W. Lactation following thoracoplasty and pneumonectomy. J. Thorac. Cardiovasc. Surg. 18: 580, 1949.
Grimm E.G. Non-puerperal galactorrhea. Northwestern Univ. Bull. Med. School 29: 350, 1955.
Berger R.L., Joison J., Braverman L.E. Lactation after incision on the thoracic cage. N. Engl. J. Med. 274: 1493, 1966.
Arora N.S., Oblinger M.J., Feldman P.S. Chronic pleural blastomycosis with hyperprolactinemia, galactorrhea, and amenorrhea. Am. Rev. Respir. Dis. 120: 451, 1979.
Morley J.E., Dawson M., Hodgkinson H., Kalk W.J. Galactorrhea and hyperprolactinemia associated with chest wall injury. J. Clin. Endocrinol. Metab. 45: 931, 1977.
Boyd A.E., Spare S., Bower B., Reichlin S. Neurogenic galactorrhea-amenorrhea. J. Clin. Endocrinol. Metab. 47: 1374, 1978.
McKiernan P., Lynch V., O’Donovan D.K. Galactorrhea (Post-thoracotomy). J. Irish. Med. Assoc. 71: 414, 1978.
MacFarlane A., Rosin M.D. Galactorrhoea following surgical procedures to the chest wall: the role of prolactin. Postgrad. Med. J. 56: 23, 1980.
Sandier M.P., Forman M.B., Lopis R., Kalk W.J. Galactorrhoea, amenorrhoea and hyperprolactinemia after an operation on the breast. S. Afr. Med. J. 57: 95, 1980.
Scully R.E., Galdabini J.J., McNeely B.U. Case Records of Massachusetts General Hospital Weekly Clinical-Pathological Exercise Case 47-1980. N. Engl. J. Med. 303: 1283, 1980.
Herman V., Kalk W.J., deMoor N.G., Levin J. Serum prolactin after chest wall surgery: elevated levels after mastectomy. J. Clin. Endocrinol. Metab. 52: 148, 1981.
Rozencwajg J., Fortune R.L. Unusual complication of thoracotomy: galactorrhea. Acta Chir. Belg. 2: 115, 1984.
Barnes A.B. Diagnosis and treatment of abnormal breast secretions. N. Engl. J. Med. 275: 1184, 1966.
Cohen R. Breast feeding without pregnancy. Pediatrics 48: 996, 1971.
Freeman D., Jennings J. Crutch-induced galactorrhea and amenorrhea. Arch. Intern. Med. 141: 1847, 1981.
Sinha Y.N., Selby F.W., Lewis J.J. A homologous radioimmunoassay for human prolactin. J. Clin. Endocrinol. Metab. 36: 509, 1973.
Pekary A.E., Hersham J.M., Parlow A.F. A sensitive and precise radioimmunoassay for human thyroid-stimulating hormone. J. Clin. Endocrinol. Metab. 41: 676, 1975.
Schalch D.S., Parker M.L A sensitive double antibody immunoassay for human growth hormone in plasma. Nature 203: 1141, 1964.
Hout W.M., Arafah B.M., Salazar R., Selman W. Evaluation of the hypothalamic-pituitary-adrenal axis immediately after pituitary adenomectomy: Is perioperative steroid therapy necessary? J. Clin. Endocrinol. Metab. 66: 1208, 1988.
Relkin R. Neurologic pathways involved in lactation: A commentary on the afferent tracts. Dis. Nerv. Syst. 28: 94, 1967.
Boyd A.E., Reichlin S. Neural control of prolactin secretion in man. Psychoneuroendocrinology 3: 113, 1977.
Kolodny R.C., Jacobs L.S., Daughaday W.D. Mammary stimulation causes prolactin secretion in non-lactating women. Nature 238: 284, 1972.
Noel G.L., Suh H.K., Frantz A.G. Prolactin release during nursing and breast stimulation in postpartum and nonpostpartum subjects. J. Clin. Endocrinol. Metab. 38: 413, 1974.
Archer D.F, Josimovich J.B. Response of serum prolactin to exogenous stimulation. Fertil. Steril. 26: 627, 1975.
Aono T., Shioji T., Shoda T., Kurachi K. The initiation of human lactation and prolactin response to suckling. J. Clin. Endocrinol. Metab. 44: 1101, 1977.
Grosvenor C.E., Whitworth N.S., Mena F. Evidence that the depletion and release phases of prolactin secretion in the lactating rat have different activation thresholds in response to exteroceptive stimulation from rat pups. Endocrinology 108: 820, 1981.
Racagni G, Apud J.A., Cocchi D., Locatelli V., Luliano E., Casanueva F., Mueller E.E. Regulation of prolactin secretion during suckling: involvement of the hypothalamo-pituitary GABAergic system. J. Endocrinol. Invest. 7: 481, 1984.
Selmanoff M., Gregerson K.A. Autofeedback effects of prolactin on basal, suckling-induced, and proestrus secretion of prolactin. Proc. Soc. Exp. Biol. Med. 175: 398, 1984.
Selmanoff M., Selmanoff C. Role of pup age, estradiol 17β and pituitary responsiveness in the differences in the suckling-induced prolactin response during early and late lactation. Biol. Reprod. 29: 400, 1983.
Zarate A., Villalobos H., Canales E.S., Soria J., Arcovedo F., Macgregor C. The effect of oral administration of thyrotropin-releasing hormone on lactation. J. Clin. Endocrinol. Metab. 43: 301, 1976.
Howie P.W., McNeilly A.S., McArdle T., Smart L., Houston M. The relationship between suckling-induced prolactin response and lactogenesis. J. Clin. Endocrinol. Metab. 50: 670, 1980.
Weitzman R.E, Leake R.D., Rubin R.T., Fisher D.A. The effect of nursing on neurohypophyseal hormone and prolactin secretion in human subjects. J. Clin. Endocrinol. Metab. 51: 836, 1980.
Melis G.B., Fruzzetti F., Paoletti A.M., Mais V., Kemeny A., Strigini F., Boldrini A., Fioretti P. Pharmacological activation of γ-aminobutyric acid-system blunts prolactin response to mechanical breast stimulation in puerperal women. J. Clin. Endocrinol. Metab. 58: 201, 1984.
Rodriguez-Arnao M.D., Peters J.R., Foord S.M., Dieguez C., Edwards C,. Gomez-Pan A., Hall R., Newcombe R.G., Scanion M.F. Exaggerated circadian variation in basal thyrotropin (TSH) and in the dopaminergic inhibition of TSH release in pathological hyperprolactinemia: evidence against a hypothalamic dopaminergic defect. J. Clin. Endocrinol. Metab. 57: 975, 1983.
Martin J.B., Reichlin S. Regulation of prolactin secretion and its disorders. In: Martin J.B., Reichlin S. (Eds.), Clinical neuroendocrinology. F.A. Davis, Philadelphia, 1987, p 201.
Ylikorkala O., Kivinen S., Reinila M. Serial prolactin and thyrotropin responses to thyrotropin-releasing hormone throughout normal human pregnancy. J. Clin. Endocrinol. Metab. 48: 288, 1979.
Antunes J.L., Louis K., Cogen P., Zimmerman E.A., Ferin M. Section of the pituitary stalk in the Rhesus monkey. Neuroendocrinology 30: 76, 1980.
Vaughan L., Carmel P.W., Dyrtenfurth I., Frantz A.G., Antunes J.L., Ferin M. Section of the pituitary stalk in the Rhesus monkey. Neuroendocrinology 30: 70, 1980.
Cronin M.J., Cheung C.Y., Weiner R.I., Goldsmith P.C. Mammotroph and gonadotroph volume percentage in the rat anterior pituitary after lesion of the medial basal hypothalamus. Neuroendocrinology 34: 140, 1982.
Burrow G.M., Wortzman G. Newcastle N.B., Holgate R.C., Kovacs K. Microadenomas of the pituitary and abnormal sella tomograms in an unselected autopsy series. N.Engl.J. Med. 304: 156, 1981.
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Kapcala, L.P., Lakshmanan, M.C. Thoracic stimulation and prolactin secretion. J Endocrinol Invest 12, 815–821 (1989). https://doi.org/10.1007/BF03350070
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DOI: https://doi.org/10.1007/BF03350070