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Serum thyroglobulin (Tg) in presence of thyroglobulin autoantibodies (TgAb). Clinical and methodological relevance of the interaction between Tg and TgAb in vitro and in vivo

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References

  1. Van Herle A.J., Vassart G., Dumont J.E. Control of thyroglobulin synthesis and secretion. N. Engl. J. Med. 301: 239, 1979.

    Article  PubMed  Google Scholar 

  2. Refetoff S., Lever G. The value of serum thyroglobulin measurement in clinical practice. JAMA 250: 2353, 1983.

    Article  Google Scholar 

  3. Feldt-Rasmussen U. Serum thyroglobulin and thyroglobulin autoantibodies in thyroid diseases. Pathogenetic and diagnostic aspects. Allergy 37: 369, 1983.

    Article  Google Scholar 

  4. Feldt-Rasmussen U., Holten I., Sand Hansen H. Influence of thyroid substitution therapy and thyroid autoantibodies on the value of serum thyroglobulin in recurring thyroid cancer. Cancer 57: 2240, 1983.

    Article  Google Scholar 

  5. Charles M.A. Comparison of serum thyroglobulin with iodine scans in thyroid cancer. J. Endocrinol. Invest. 5: 267, 1982.

    Article  PubMed  CAS  Google Scholar 

  6. Hjort T. Determination of serum thyroglobulin by a haemagglutination-inhibition test. Lancet 7: 1262, 1961.

    Article  Google Scholar 

  7. Roitt I.M., Torrigiani G. Identification and estimation of undegraded thyroglobulin in human serum. Endocrinology 81: 421, 1967.

    Article  PubMed  CAS  Google Scholar 

  8. Van Herle A.J., Uller R.P., Matthews N.L, Brown J. Radioimmunoassay for measurement of thyroglobulin in human serum. J. Clin. Invest. 52: 1320, 1973.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Bayer M.F., Kriss J.P. Immunoradiometric assay for serum thyroglobulin: semiquantitative measurement of thyroglobulin in antithyroglobulin positive sera. J. Clin. Endocrinol. Metab. 49: 557, 1979.

    Article  PubMed  CAS  Google Scholar 

  10. Kastrup J., Feldt-Rasmussen U., Bartram H.R., Witten J., Hansen H.S. An enzyme-linked immunosorbent assay (ELISA) for measurement of human serum thyroglobulin. Evaluation of the influence of thyroglobulin auto-antibodies. Scand. J. Clin. Lab. Invest. 45: 471, 1985.

    Article  PubMed  CAS  Google Scholar 

  11. Fulthorpe A.N., Roitt I.M., Doniach D., Couchman K. A stable sheep cell preparation for detecting thyroglobulin autoantibodies and its clinical application. J. Clin. Pathol. 76: 654, 1961.

    Article  Google Scholar 

  12. Feldt-Rasmussen U., Perrild H., Bech K., Bliddal H., Date J., Høier-Madsen M., Nordfang O., Ryder L.P., Thomsen M., Kappelgaard E., Nielsen H. Discrepancy between haemagglutination and radioimmunological techniques for measurement of serum thyroglobulin autoantibodies. Allergy 38: 49, 1982.

    Article  Google Scholar 

  13. Høier-Madsen M., Feldt-Rasmussen U., Hegedus L., Perrild H., Hansen H.S. Enzyme-linked immunosorbent assay for determination of thyroglobulin autoantibodies. Acta Pathol. Microbiol. Scand. (C) 92: 377, 1984.

    Google Scholar 

  14. Ewins D.L, Wilkin T.J. A clinical comparison of the enzyme-linked immunosorbent assay (ELISA) and haemagglutination (TRC) in the routine detection of antithyroglobulin antibodies. Acta Endocrinol. (Kbh.) 103: 216, 1983.

    CAS  Google Scholar 

  15. Wilkin T.J., Swanson Beck J., Hayes P.C., Potts R.C., Young R.J. A passive haemagglutination (TRC) inhibitor in thyrotoxic serum. Clin. Endocrinol. (Oxf.) 10: 507, 1979.

    Article  CAS  Google Scholar 

  16. Schneider A.B., Pervos R. Radioimmunoassay of human thyroglobulin. Effect of antithyroglobulin autoantibodies. J. Clin. Endocrinol. Metab. 47: 126, 1978.

    Article  PubMed  CAS  Google Scholar 

  17. Feldt-Rasmussen U., Hyltoft Petersen P., Date J., Madsen C.M. Sequential changes in serum thyroglobulin (Tg) and its autoantibodies (TgAb) following subtotal thyroidectomy of patients with preoperatively detectable TgAb. Clin. Endocrinol. (Oxf.) 12: 29, 1980.

    Article  CAS  Google Scholar 

  18. Ratcliffe J.G., Ayob Law, Pearson D. The measurement of serum thyroglobulin in the presence of thyroglobulin antibodies. Clin. Endocrinol. (Oxf.) 15: 507, 1981.

    Article  CAS  Google Scholar 

  19. Mariotti S., Cupini C., Giani C., Lari R., Rolleri E., Falco A., Marchisio M., Pinchera A. Evaluation of a solid-phase immunoradiometric assay (IRMA) for serum thyroglobulin. Clin. Chim. Acta 123: 347, 1982.

    Article  PubMed  CAS  Google Scholar 

  20. Bayer M.F., McDougall I.R. Differences in radioimmunoassay results for thyroglobulin that affect management of patients with thyroid cancer. Clin. Chem. 30: 81, 1984.

    PubMed  CAS  Google Scholar 

  21. Krogh Rasmussen A., Feldt-Rasmussen U., Date J., Witten J., Sand Hansen H., Funch-Rosenberg H. Comparison of two assays for serum thyroglobulin and relation to thyroglobulin autoantibodies. In: Proceedings of 1 st European symposium on thyroid cancer, Montpellier 1985, Elsevier Science Publishers (In press).

    Google Scholar 

  22. Noguchi S., Kato K. Determination of serum thyroglobulin with monoclonal antibody without interference by autoantibody. 5th International Congress of Immunology, Kyoto, Japan, p. 68, 1983, (Abstract).

    Google Scholar 

  23. Ruf J., Carayon P., Lissitzky S. Various expression of a unique anti-human thyroglobulin antibody repertoire in normal state and autoimmune disease. Eur. J. Immunol. 15: 268, 1985.

    Article  PubMed  CAS  Google Scholar 

  24. Black E.G., Hoffenberg R. Should one measure serum thyroglobulin in the presence of anti-thyroglobulin antibodies? Clin. Endocrinol. (Oxf.) 19: 597, 1983.

    Article  CAS  Google Scholar 

  25. Krogh Rasmussen A., Feldt-Rasmussen U., Sand Hansen H., Witten J. Thyroglobulin determinations in follow-up of patients with differentiated thyroid carcinoma. In: Hufner M., Reiners C. (Eds.), Thyroglobulin and thyroglobulin antibodies in the follow-up of thyroid cancer and endemic goiter. Georg Van Thieme Verlag, Stuttgart (In press).

  26. Schatz H., Grebe S.F., Horn W., Muller H. Nachsorge bei differenziertem Schilddrusenkarzinom: Serum thyreoglobulinbestimmung statt routinemassigem 131Jod-Szintigramm? Wien. Klin. Wochenschr. 10: 389, 1984.

    Google Scholar 

  27. Grant S., Luttrell B., Reeve T., Wiseman J., Wilmshurst E., Stiel J., Donohoe D., Cooper R., Bridgman M. Thyroglobulin may be undetectable in the serum of patients with metastatic disease secondary to differentiated thyroid carcinoma. Cancer 54: 1625, 1984.

    Article  PubMed  CAS  Google Scholar 

  28. Bayer M.F., Kriss J.P. A solid phase, sandwich: type radioimmunoassay for antithyroglobulin: elimination of false positive results and semiquantitative measurement of antithyroglobulin in the presence of elevated thyroglobulin. J. Clin. Endocrinol. Metab. 49: 565, 1979.

    Article  PubMed  CAS  Google Scholar 

  29. Mariotti S., Pisani S., Russova A., Pinchera A. A new solid-phase immunoradiometric assay for antithyroglobulin autoantibody. J. Endocrinol. Invest. 5: 227, 1982.

    Article  PubMed  CAS  Google Scholar 

  30. Feldt-Rasmussen U., Høier-Madsen M., Hansen H.S., Blichert-Toft M. Comparison between homogenous phase radioassay and enzyme-linked immunosorbent assay for measurement of antithyroglobulin antibody-content in serum. Relation to presence of thyroglobulin. Acta Pathol. Microbiol. Scand. (C) (In press).

  31. Henniker A.J., Luttrell B.M., Ward P., Stiel J.N., Wilmshurst E.G. The measurement of antithyroglobulin auto-antibodies in the presence of thyroglobulin. J. Endocrinol. Invest. 6: 277, 1983.

    Article  PubMed  CAS  Google Scholar 

  32. Pinchera A., Mariotti S., Vitti P., Tosi M., Grasso L., Pacini F., Buti R., Baschieri L. Interference of serum thyroglobulin in the radioassay for serum antithyroglobulin antibodies. J. Clin. Endocrinol. Metab. 45: 1077, 1977.

    Article  PubMed  CAS  Google Scholar 

  33. Mariotti S., Kaplan E.S., Medof M.E., DeGroot L.J. Circulating thyroid antigen-antibody immune complexes. In: Stockigt J.R., Nagataki S., (Eds.), Thyroid VIII. Australian Academy of Science, Melbourne, 1980, p. 696.

    Google Scholar 

  34. Feldt-Rasmussen U., Blichert-Toft M., Christiansen C., Date J. Serum thyroglobulin and its autoantibody following subtotal thyroid resection of Graves’ disease. Eur. J. Clin. Invest. 12: 203, 1982.

    Article  PubMed  CAS  Google Scholar 

  35. Bech K., Feldt-Rasmussen U., Bliddal H., Date J., Blichert-Toft M. The acute changes in thyroid stimulating immunoglobulins, thyroglobulin and thyroglobulin antibodies following subtotal thyroidectomy. Clin. Endocrinol. (Oxf.) 16: 235, 1982.

    Article  CAS  Google Scholar 

  36. Feldt-Rasmussen U., Schlumberger M. European collaborative study evaluating serum thyroglobulin standards. In: Hufner M., Reiners C. (Eds.), Thyroglobulin and thyroglobulin antibodies in the follow-up of thyroid cancer and endemic goiter. Georg Van Thieme Verlag, Stuttgart (In press).

  37. Takeda Y., Kriss P. Radiometric measurement of thyroglobulin-antithyroglobulin immune complexes in human serum. J. Clin. Endocrinol. Metab. 44: 46, 1977.

    Article  PubMed  CAS  Google Scholar 

  38. Mariotti S., DeGroot L.J., Scarborough D., Medof M.E. Study of circulating immune complexes in thyroid diseases: Comparison of Raji cell radioassay and specific thyroglobulin-antithyroglobulin radioassay. J. Clin. Endocrinol. Metab. 49: 679, 1979.

    Article  PubMed  CAS  Google Scholar 

  39. Feldt-Rasmussen U., Husby S., Date J., Blabjerg O., Nielsen H. In vitro characterization of thyroglobulin immune complexes Allergy 36: 107, 1981.

    Article  PubMed  CAS  Google Scholar 

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Feldt-Rasmussen, U., Krogh Rasmussen, A. Serum thyroglobulin (Tg) in presence of thyroglobulin autoantibodies (TgAb). Clinical and methodological relevance of the interaction between Tg and TgAb in vitro and in vivo . J Endocrinol Invest 8, 571–576 (1985). https://doi.org/10.1007/BF03348564

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