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Association of serum pigment epithelium-derived factor with high-sensitivity C-reactive protein in women with polycystic ovary syndrome

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Abstract

Background: The basic studies showed that Pigment epithelium-derived factor (PEDF) plays an important role in inflammation. Aim: This study aims to investigate the association of serum PEDF with high-sensitivity C-reactive protein (hs-CRP) in women with polycystic ovary syndrome (PCOS). Methods: Ninety-six PCOS women and 63 healthy, age-matched controls were enrolled in this study. Serum levels of PEDF, hs-CRP, Complement C3 (C3), glucose, insulin, lipids, and total testosterone were measured. Ninety-six PCOS women and 20 controls underwent hyperinsulinemic-euglycemic clamp to assess their insulin sensitivity, which was expressed as M value. Results: Serum PEDF levels and hs-CRP levels were much higher in PCOS women than in controls. In PCOS women, PEDF positively correlated with body mass index (BMI), hs-CRP, C3, LDL cholesterol (LDL-c), and systolic blood pressure (SBP), and negatively correlated with M value and HDL cholesterol (HDL-c). After controlling for BMI, PEDF was still positively correlated with hs-CRP. Multiple linear regression analysis revealed that in PCOS women, hs-CRP, SBP, LDL-c and M value were independent determinants of serum PEDF. Conclusion: The serum PEDF levels are closely associated with hs-CRP in women with PCOS. PEDF may play a role in the development of chronic inflammation in PCOS.

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Authors and Affiliations

  1. Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, Chongqing, China

    Q. Cheng, W. Xia, S. Yang, P. Ye, M. Mei, Y. Song, M. Luo & Q. Li MD, PhD

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  1. Q. Cheng
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  2. W. Xia
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  3. S. Yang
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  4. P. Ye
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  5. M. Mei
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  6. Y. Song
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  7. M. Luo
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  8. Q. Li MD, PhD
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Corresponding author

Correspondence to Q. Li MD, PhD.

Additional information

Qingfeng Cheng and Wei Xia are co-first authors and contributed equally to this paper.

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Cheng, Q., Xia, W., Yang, S. et al. Association of serum pigment epithelium-derived factor with high-sensitivity C-reactive protein in women with polycystic ovary syndrome. J Endocrinol Invest 36, 632–635 (2013). https://doi.org/10.1007/BF03346755

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