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Preventing skeletal complications in androgen deprived men with prostate cancer: Time for action

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References

  1. Huggins C, Stevens RE Jr, Hodges CV. Studies on prostatic cancer. II. The effects of castration on advanced carcinoma of the prostate gland. Arch Surg 1941, 43: 209–23.

    Article  CAS  Google Scholar 

  2. Bolla M, Gonzalez D, Warde P, et al. Improved survival in patients with locally advanced prostate cancertreated with radiotherapy and goserelin. N Engl J Med 1997, 337: 295–300.

    Article  CAS  PubMed  Google Scholar 

  3. Basaria S, Lieb J 2nd, Tang AM, et al. Long-term effects of androgen deprivation therapy in prostate cancer patients. Clin Endocrinol (Oxf) 2002, 56: 779–86.

    Article  CAS  Google Scholar 

  4. Smith MR, Finkelstein JS, McGovern FJ, et al. Changes in body composition during androgen deprivation therapy for prostate cancer. J Clin Endocrinol Metab 2002, 87: 599–603.

    Article  CAS  PubMed  Google Scholar 

  5. Smith JC, Bennett S, Evans LM, et al. The effects of induced hypogonadism on arterial stiffness, body composition, and metabolic parameters in males with prostate cancer. J Clin Endocrinol Metab 2001, 86: 4261–7.

    Article  CAS  PubMed  Google Scholar 

  6. Dockery F, Bulpitt CJ, Agarwal S, Rajkumar C. Testosterone suppression in men with prostate cancer is associated with increased arterial stiffness. Aging Male 2002, 5: 21 6–22.

    Article  Google Scholar 

  7. Orwoll ES, Klein RF. Osteoporosis in men. Endocr Rev 1995, 16: 87–116.

    Article  CAS  PubMed  Google Scholar 

  8. Stanley HL, Schmitt BP, Poses RM, Deiss WP. Does hypogonadism contribute to the occurrence of a minimal trauma hip fracture in elderly men? J Am Geriatr Soc 1991, 39: 766–71.

    Google Scholar 

  9. Stoch SA, Parker RA, Chen L, et al. Bone loss in men with prostate cancer treated with gonadotropin-releasing hormone agonists. J Clin Endocrinol Metab 2001, 86: 2787–91.

    CAS  PubMed  Google Scholar 

  10. Maillefert JF, Sibilia J, Michel F, et al. Bone mineral density in men treated with synthetic gonadotropin-releasing hormone agonists for prostatic carcinoma. J Urol 1999, 161: 1219–22.

    Article  CAS  PubMed  Google Scholar 

  11. Mittan D, Lee S, Miller E, et al. Bone loss following hypogonadism in men with prostate cancer treated with GnRH analogs. J Clin Endocrinol Metab 2002, 87: 3656–61.

    Article  CAS  PubMed  Google Scholar 

  12. Wei JT, Gross M, Jaffe CA, et al. Androgen deprivation therapy for prostate cancer results in significant loss of bone density. Urology 1999, 54: 607–11.

    Article  CAS  PubMed  Google Scholar 

  13. Smith MR, McGovern FJ, Fallon MA, et al. Low bone mineral density in hormone-naive men with prostate carcinoma. Cancer 2001, 91: 2238–45.

    Article  CAS  PubMed  Google Scholar 

  14. Townsend MF, Sanders WH, Northway RO, Graham SD Jr. Bone fractures associated with luteinizing hormone-releasing hormone agonists used in the treatment of prostate carcinoma. Cancer 1997, 79: 545–50.

    Article  CAS  PubMed  Google Scholar 

  15. Daniell HW. Osteoporosis after orchiectomy for prostate cancer. J Urol 1997, 157: 439–44.

    Article  CAS  PubMed  Google Scholar 

  16. Shahinian VB, Kuo YF, Freeman JL, Goodwin JS. Risk of fracture after androgen deprivation for prostate cancer. N Engl J Med 2005, 352: 154–64.

    Article  CAS  PubMed  Google Scholar 

  17. Oefelein MG, Ricchuiti V, Conrad W, et al. Skeletal fracture associated with androgen suppression induced osteoporosis: the clinical incidence and risk factors for patients with prostate cancer. J Urol 2001, 166: 1724–8.

    Article  CAS  PubMed  Google Scholar 

  18. Oefelein MG, Ricchiuti V, Conrad W, Resnick MI. Skeletal fractures negatively correlate with overall survival in men with prostate cancer. J Urol 2002, 168: 1005–7.

    Article  PubMed  Google Scholar 

  19. Smith MR, McGovern FJ, Zietman AL, et al. Pamidronate to prevent bone loss during androgen-deprivation therapy for prostate cancer. N Engl J Med 2001, 345: 948–55.

    Article  CAS  PubMed  Google Scholar 

  20. Smith MR, Eastham J, Gleason DM, et al. Randomized controlled trial of zoledronic acid to prevent bone loss in men receiving androgen deprivation therapy for nonmetastatic prostate cancer. J Urol 2003, 169: 2008–12.

    Article  CAS  PubMed  Google Scholar 

  21. Tanvetyanon T. Physician practices of bone density testing and drug prescribing to prevent or treat osteoporosis during androgen deprivation therapy. Cancer 2005, 103: 237–41.

    Article  PubMed  Google Scholar 

  22. Morabito N, Gaudio A, Lasco A, et al. Neridronate prevents bone loss in patients receiving androgen deprivation therapy for prostate cancer. J Bone Miner Res 2004, 19: 1766–70.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to S. Basaria MD.

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Braga-Basaria, M., Basaria, S. Preventing skeletal complications in androgen deprived men with prostate cancer: Time for action. J Endocrinol Invest 29, 467–470 (2006). https://doi.org/10.1007/BF03344132

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