Abstract
The aim of this report was to evaluate the incidence of Type 1 diabetes mellitus (T1DM) in the district of Catania (eastern Sicily) in children under 15 yr of age over a ten-yr period (01/01/1989 — 31/12/1998) in relation to age, sex, monthly-seasonal variability, calendar yr and spatial clustering. The estimated completeness of our register was 99.2%. The overall incidence rate was 12.38 per 100,000 during the period of the study. Twenty-four percent of cases were 0–4 yr at diagnosis, 42% were 5–9 yr and 34% were 10–14 yr. More males (no. 148) than females (no. 125) were newly diagnosed with a male/female ratio similar to the base population ratio in the range 0–14 yr and within age groups. The study revealed a non-random spatial distribution of T1DM incidence in children not accounted for by known demographic factors. A significant seasonal pattern and temporal trend of incidence were also detected.
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References
La Porta R.E., Tajima N., Akerblom H.K., et al. Geographic differences in the risk of insulin-dependent diabetes mellitus: the importance of registries. Diabetes Care 1985, 8: 101–107.
Diabetes Epidemiology Research International Group Geographic patterns of childhood insulin-dependent diabetes mellitus. Diabetes 1998, 37: 1113–1119.
Bingley P.D., Gale E.A.M. Rising incidence of IDDM in Europe. Diabetes Care 1989, 12: 289.
Green A., Gale E.A., Patterson C.C., for Eurodiab ACE Study Group Incidence of childhood-onset insulin-dependent diabetes mellitus: the Eurodiab ACE Study. Lancet 1992, 339: 905–909.
The Eurodiab Tiger Study Group Recent trends in the incidence of Type 1 diabetes in European children. Diabetologia 1998, 41: A21 (Abstract).
Songini M., Bernardinelli L., Clayton D., et al. The Sardinian IDDM study: 1. Epidemiology and geographical distribution of IDDM in Sardinia during 1989 to 1994. Diabetologia 1998, 41: 221–227.
Akerblom H.K., Knip M. Putative environmental factors in Type 1 diabetes. Diabetes Metab. Rev. 1998, 14: 31–67.
Law G.R., McKinney P., Staines A., et al. Clustering of childhood IDDM. Diabetes Care 1997, 20: 753–756.
Arpi M.L., Italia S., Motta R.M., et al. Incidence of Type 1 diabetes in the District of Catania, Sicily. Acta Diabetol. 1994, 31: 37–39.
Bishop Y.M.M., Fiemberg S.E., Holland P.W. Discrete multivariate analysis: theory and practice. MIT press, Cambridge, 1974, p. 231–233.
ISTAT (Istituto Nazionale di Statistica). Classificazione dei comuni secondo le caratteristiche urbane e rurali. Note e relazioni, anno 1986, vol. 2. Grafiche Chicca, Tivoli, Italy.
Basel M. Documenta mathematies and statistica Ciba- Geigy, 1970, formula 804, p. 189.
Vichi M., Oppiz O. Classification and data analysis. Springer-Verlag, Heidelberg, 1999, p. 55–56.
Dagum E.B. Modelling, forecasting and seasonally adjusting economic time series with the K-II-ARIMA Method. Statistician 1978, 1: 3–4.
Sebastiani L., Visalli N., Adorisio E., et al. A 5-year (1989–1993) prospective study of the incidence of IDDM in Rome and the Lazio region in the age-group 0–14 years. Diabetes Care 1996, 1: 70–73.
Padaiga Z., Tuomilehto J., Karvonen M., et al. Incidence trends in childhood onset IDDM in four countries around the Baltic sea during 1983–1993. Diabetologia 1997, 40: 187–192.
Levy-Marchal C., Patterson C., Green A., on Behalf of the Eurodiab ACE Study Group Variation by age group and seasonality at diagnosis of childhood IDDM in Europe. Diabetologia 1995, 38: 823–830.
Virtanen S.M., Hyppönen E., Laara E., et al. Cow’s milk consumption, disease-associated autoantibodies and Type 1 diabetes mellitus: a follow-up study in siblings of diabetic children. Childhood Diabetes in Finland Study Group. Diabet. Med. 1998, 15: 730–738.
Muntoni S., Cocco P., Aru G., et al. Nutritional factors and risk of Type 1 diabetes. Diabetologia 1998, 41: A91 (Abstract).
Hummel M., Schenker M., Ziegler A.G. and The Baby-Diab Study Group. Appearance of diabetes-associated antibodies in offspring of parents with Type 1 diabetes is independent from environmental factors. Diabetologia 1998, 41: A91 (Abstract).
The Eurodiab ACE Study Group and the Eurodiab ACE Substudy 2 Study Group Familial risk of Type 1 diabetes in European children. Diabetologia 1998, 41: 1151–1156.
Cherubini V., Carle F., Gesuita R., et al. Large incidence variation of Type 1 diabetes in central-southern Italy 1990–1995: lower risk in rural areas. Diabetologia 1999, 42: 789–792.
Karvonen M., Rusanen J., Sundberg M., et al. Regional differences in the incidence of insulin-dependent diabetes mellitus among children in Finland from 1987 to 1991. Childhood Diabetes in Finland (DiMe) Study Group. Ann. Med. 1997, 29: 297–304.
Parslow R.C., McKinney P.A., Law G.R., et al. Incidence of childhood diabetes mellitus in Yorkshire, Northern England, is associated with nitrate in drinking water: an ecological analysis. Diabetologia 1997, 40: 550–556.
Gamble D.R. The epidemiology of insulin-dependent diabetes with particular reference to the relationship of virus infection to its etiology. Epidemiol. Rev. 1990, 2: 49–70.
Onkamo P., Vaananen S., Karvonen M., Tuomilehto J. Worldwide increase in incidence of Type 1 diabetes — the analysis of the data on published incidence trends. Diabetologia 1999, 42: 1395–1403.
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Arpi, M.L., Fichera, G., Mancuso, M. et al. A ten-year (1989–1998) perspective study of the incidence of Type 1 diabetes in the district of Catania (Sicily) in a 0–14 year age group. J Endocrinol Invest 25, 414–419 (2002). https://doi.org/10.1007/BF03344030
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DOI: https://doi.org/10.1007/BF03344030