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Physical activity and cardiovascular health in the elderly

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Abstract

People over the age of 65 constitute a growing proportion of the world population both in western and in developing countries. A unique feature of this group is the high prevalence of cardiovascular diseases, which negatively affect its quality of life as well as its life expectancy. Among the interventions able to reduce the health burden of cardiovascular diseases is physical activity. The benefits of physical activity have been demonstrated both in healthy and chronically ill elderly subjects, while the risks have been found to be modest. Physicians should recommend moderate-intensity physical activity to sedentary older subjects, who are still the majority within the elderly population.

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References

  1. Caspersen C.J., Powell K.E., Christenson G.M.: Physical activity, exercise and physical fitness: definitions and distinctions for health-related research. Public Health Rep. 100: 126–131, 1985.

    CAS  PubMed Central  PubMed  Google Scholar 

  2. Mittelmark M.B.: The epidemiology of aging. In: Hazzard W.R., Bierman E.L., Blass J.P., Ettinger Jr. W.H., Halter J.B. (Eds.), Principles of Geriatric Medicine and Gerontology, ed. 3. McGraw-Hill Book Company, New York, 1994, pp. 135–151.

    Google Scholar 

  3. Lakatta E.G.: Cardiovascular regulatory mechanisms in advanced age. Physiol. Rev. 73: 413–467, 1993.

    CAS  PubMed  Google Scholar 

  4. Fleg J.L., O’Connor F., Gerstenblith G., Becker L.C., Clulow J., Schulman J.P., Lakatta J.: Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. J. Appl. Physiol. 78: 890–900,1995.

    CAS  PubMed  Google Scholar 

  5. Bryg R.J., Williams G.A., Labowitz A.J.: Effect of aging on left ventricular diastolic filling in normal subjects. Am. J. Cardiol. 59: 971–974, 1987.

    CAS  PubMed  Google Scholar 

  6. Lakatta E.G.: Cardiovascular reserve capacity in healthy older humans. Aging Clin. Exp. Res. 6: 213–223, 1994.

    CAS  Google Scholar 

  7. Vaitkevicius P.V., Fleg J.L., Engel J.H., O’Connor F.C., Wright J.C., Lakatta L.E., Yin F.C.P., Lakatta E.G.: Effects of age and aerobic capacity on arterial stiffness in healthy adults. Circulation 88: 1456–1462, 1993.

    CAS  PubMed  Google Scholar 

  8. Rodeheffer R.J., Gersternblith G., Becker C.C., Fleg J.L., Weisfeldt M.L., Lakatta E.G.: Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilatation and increased stroke volume compensate for a diminished heart rate. Circulation 69: 203–213, 1984.

    CAS  PubMed  Google Scholar 

  9. Stratton J.R., Cerqueira M.D., Schwartz R.S., Levy W.C., Veith R.C., Kahn S.E., Abrass I.B.: Differences in cardiovascular responses to isoproterenol in relation to aging and exercise training in healthy men. Circulation 86: 504–512, 1992.

    CAS  PubMed  Google Scholar 

  10. Van Brummelen P., Buhler F.R., Kiowski W., Amann F.W.: Age-related decrease in cardiac and peripheral vascular responsiveness to isoprenaline: studies in normal subjects. Clin. Sci. 60: 571–577, 1981.

    PubMed  Google Scholar 

  11. Stratton J.R., Lewy W.C., Schwartz R.S., Abrass I.B., Cerqueira M.D.: β-adrenergic effects on left ventricular filling: influence of aging and exercise training. J. Appl. Physiol. 177: 2522–2529, 1994.

    Google Scholar 

  12. Fleg J.L., Schulman S., O’Connor F., Becker L.C., Gerstenblith G., Clulow J.F., Renlund D.G., Lakatta E.G.: Effects of acute beta adrenergic receptor blockade on age-associated changes in cardiovascular performance during dynamic exercise. Circulation 90: 2333–2341, 1994.

    CAS  PubMed  Google Scholar 

  13. Astrand P.O., Rodahl K.: Textbook of work physiology. McGraw Hill Company Book, New York, 1986.

    Google Scholar 

  14. Buskirk E.R., Hodgson J.L.: Age and aerobic power: the rate of change in men and women. Fed. Proc. 46: 1824–1829, 1987.

    CAS  PubMed  Google Scholar 

  15. Ogawa T., Spina R.J., Martin III W.H., Kohrt W.M., Schechtman K.B., Holloszy J.O., Ehsani A.A.: Effects of aging, sex and physical training on cardiovascular responses to exercise. Circulation 86: 494–503, 1992.

    CAS  PubMed  Google Scholar 

  16. Fleg J.L., Lakatta E.G.: Role of muscle loss in the age associated reduction in VO2 max. J. Appl. Physiol. 65: 1147–1151, 1986.

    Google Scholar 

  17. Buchner D.M., Beresdorf S.A.A., Larson E.B., La Croix A.Z., Wagner E.H.: Effects of physical activity on health status in older adults: intervention studies. Annu. Rev. Public Health 13: 469–488, 1992.

    CAS  PubMed  Google Scholar 

  18. Greig C., Young A.: Aerobic exercise. In: Evans J.G., Williams T.F. (Eds.), Oxford Textbook of Geriatric Medicine. Oxford University Press, New York, 1992, pp. 601–604.

    Google Scholar 

  19. Saltin B.: Fysisk edlgholdelse hos aeldre. Aerob bejdsevne. Månedsskrift for Patrisk Copenhagen 58: 193–216, 1980.

    Google Scholar 

  20. Kraus H., Raab W.: Hypokinetic disease. Thomas C.C. Publ., Springfield, 1980.

    Google Scholar 

  21. Saltin B., Blomqvist G., Mitchell J., Johnson R.L., Widenthal K., Chapman C.B.: Response to exercise after bed rest and after training. Circulation 37 (Suppl. VII): 1–78, 1968.

    Google Scholar 

  22. Ehsani A.A., Ogawa T., Miller T.R., Spina R.J., Jilka S.M.: Exercise training improves left ventricular systolic function in older men. Circulation 83: 96–103, 1991.

    CAS  PubMed  Google Scholar 

  23. Stratton J.R., Levy W.C., Cerqueira M.D., Schwartz R.S., Abrass I.B: Cardiovascular response to exercise. Effects of aging and exercise training in healthy men. Circulation 89: 1648–1655, 1994.

    CAS  PubMed  Google Scholar 

  24. Spina R.J., Ogawa T., Kohrt W.M., Martin III W.H., Holloszy J.O., Ehsani A.A.: Differences in cardiovascular adaptations to endurance exercise training between older men and women. J. Appl. Physiol. 75: 849–855, 1993.

    CAS  PubMed  Google Scholar 

  25. Fleg J.L., Shapiro E.P., O’Connor F., Taube J., Goldberg A.P., Lakatta E.G.: Left ventricular diastolic filling performance in older male athletes. JAMA 273: 1371–1375, 1995.

    CAS  PubMed  Google Scholar 

  26. Spina R.J., Miller T.R., Bogenhagen W.H., Schechtman K.B., Ehsani A.A.: Gender-related differences in left ventricular filling dynamics in older subjects after endurance training. J. Gerontol. 51A: B232–B237, 1996.

    Google Scholar 

  27. Rogers M.A., Hagberg J.M., Martin III W.H., Ehsani A.A., Holloszy J.O.: Decline in VO2max with aging in master athletes and sedentary men. J. Appl. Physiol. 168: 2195–2199, 1990.

    Google Scholar 

  28. Hagberg J.M., Graves J.E., Limacher M., Woods D.R., Leggett S.H., Cononie C., Gruber J.J., Pollock M.L.: Cardiovascular responses of 70 to 79 years old men and women to exercise training. J. Appl. Physiol. 66: 2589–2594, 1989.

    CAS  PubMed  Google Scholar 

  29. Pollock M., Mengelkoch J., Graves J., Lowenthal D.T., Limacher M., Foster C., Wilmore J.: Twenty-year follow-up of aerobic power and body composition of older track athletes. J. Appl. Physiol. 82: 1508–1516, 1997.

    CAS  PubMed  Google Scholar 

  30. Mengelkoch L.J., Pollock M.L., Limacher M.C., Graves J.E., Riley W.J., Shireman R.B., Lowenthal D.T., Leon A.S.: Effects of age, physical training and physical fitness on coronary heart disease risk factors in elderly track athletes at twenty-year follow-up. J. Am. Geriatr. Soc. 45: 1446–1453, 1997.

    CAS  PubMed  Google Scholar 

  31. Fiatarone M.A., O’Neill E.F., Ryan N.D., Clements K.M., Solares G.R., Nelson M.E., Roberts S.B., Kehayias J.J., Lipsitz L.A., Evans W.J.: Exercise training and nutritional supplementation for physical frailty in very elderly people. N. Engl. J. Med. 330: 1769–1775, 1994.

    CAS  PubMed  Google Scholar 

  32. Foster V.L., Hume G.J.E., Byrnes W.C., Dickinson A.L., Chatfield S.J.: Endurance training for elderly women: moderate vs low intensity. J. Gerontol. 44: M184–M188, 1989.

    CAS  PubMed  Google Scholar 

  33. Mor V., Murphy J., Masterson-Allen S., Willey C., Razmpour A., Jackson M.E., Greer D., Katz S.: Risk of functional decline among well-elders. J. Clin. Epidemiol. 42: 895–904, 1989.

    CAS  PubMed  Google Scholar 

  34. Simonsick E.M., Lafferty M.E., Phillips C.L., Mendes de Leon C.F., Kasl S.V., Seeman T.E., Fillenbaum G., Hebert P., Lemke J.H.: Risk due to inactivity in physically capable older adults. Am. J. Public Health 83: 1443–1450, 1993.

    CAS  PubMed  Google Scholar 

  35. Newschafer C.J., Bush T.L., Hale W.E.: Aging and total cholesterol levels: cohort, period, and survivorship effects. Am. J. Epidemiol. 136: 23–34, 1992.

    Google Scholar 

  36. Benfante R., Reed D.: Is elevated serum cholesterol level a risk factor for coronary heart disease in the elderly? JAMA 263: 393–396, 1990.

    CAS  PubMed  Google Scholar 

  37. Simons L., Friedlander Y., Simons J., McCallum J.: Lipoprotein(a) is not associated with coronary heart disease in the elderly: cross sectional data from the Dubbo study. Atherosclerosis 99: 2540–2544. 1993.

    Google Scholar 

  38. Kario K., Matsuo T., Imiya M., Kayaba K., Kuroda T., Nago N., Matsuo H., Shimada K.: Close relation between lipoprotein(a) levels and atherothrombotic disease in Japanese subjects >75 years of age. Am. J. Cardiol. 73: 1187–1190, 1994.

    CAS  PubMed  Google Scholar 

  39. Kannel W.B., Vokonas P.S.: Primary risk factors for coronary heart disease in the elderly: The Framingham Study. In: Wenger N.K., Furberg C.D. (Eds.), Coronary heart disease in the elderly: working conference on the recognition and management of coronary heart disease in the elderly. Elsevier, New York, 1986, pp. 60–92.

    Google Scholar 

  40. Rubin S.M., Sidney S., Black D.M., Browner W.S., Hulley S.B., Cummings S.R.: High blood cholesterol in elderly men and the excess risk for coronary heart disease. Ann. Intern. Med. 113: 916–920, 1990.

    CAS  PubMed  Google Scholar 

  41. Krumholz H.M., Seeman T.E., Merrill S.S., Mendes de Leon C.F., Vaccarino V., Silverman D.J., Tsukahara R., Ostfeld A.M., Berkman R.F.: Lack of association between cholesterol and coronary heart disease mortality and morbidity and all-cause mortality in persons older than 70 years. JAMA 272: 1335–1340, 1994.

    CAS  PubMed  Google Scholar 

  42. LaRosa J.C.: Dyslipidemia and coronary heart disease in the elderly. Clin. Geriatr. Med. 12: 33–40, 1996.

    CAS  PubMed  Google Scholar 

  43. Reaven P.D., McPhillips J.B., Barret-Connor E.L., Criqui M.H.: Leisure time exercise and lipid and lipoprotein levels in an older population. J. Am. Geriatr. Soc. 38: 847–854, 1990.

    CAS  PubMed  Google Scholar 

  44. Tamai T., Nakai T., Takai H., Fujiwara R., Miyabo S., Higuchi M., Kobayashi S.: The effects of physical exercise on plasma lipoprotein and apolipoprotein metabolism in elderly men. J. Gerontol. 43: M75–M79, 1988.

    CAS  PubMed  Google Scholar 

  45. Schwartz R.S., Cain K.C., Shuman W.P., Larson V., Stratton J.R., Beard J.C., Kahn S.E., Cerqueira M.D., Abrass I.B.: Effect of intensive endurance training on lipoprotein profiles in young and older men. Metabolism 41: 545–551, 1991.

    Google Scholar 

  46. Duncan J.J., Gordon N.F., Scott C.B.: Women walking for health and fitness. How much is enough? JAMA 266: 3295–3299, 1991.

    CAS  PubMed  Google Scholar 

  47. King A.B., Haskell W.L., Young D.R., Oka R.K., Stefanick M.L.: Long-term effects of varying intensities and formats of physical activity on participation rates, fitness and lipoproteins in men and women aged 50 to 65 years. Circulation 91: 2596–2604, 1995.

    CAS  PubMed  Google Scholar 

  48. Cauley J.A., Kruska A.M., La Porte R.E., Sandler R.B., Panbianco G.: A 2-year randomized exercise trial in older women: effects on HDLcholesterol. Atherosclerosis 66: 247–251, 1987.

    CAS  PubMed  Google Scholar 

  49. Houmard J.A., Bruno N.J., Bruner R.K., McCammon M.R., Israel R.G., Barakat H.A.: Effects of exercise training on chemical composition of plasma LDL. Arterioscler. Thromb. 14: 325–330, 1994.

    CAS  PubMed  Google Scholar 

  50. Hubinger L., Mackinnon T.L., Lepre F.: Lipoprotein(a) levels in middle-aged male runners and sedentary controls. Med. Sci. Sports Exerc. 27: 490–496, 1995.

    CAS  PubMed  Google Scholar 

  51. Hellsten G., Boman K., Hallmans G., Dahlen G.: Lipids and endurance physical activity. Atherosclerosis 75: 93–94, 1989.

    CAS  PubMed  Google Scholar 

  52. Shimokata H., Tobin J.D., Muller D., Elahi D., Coon P.J., Andres R.A.: Studies in the distribution of body fat. I. Effects of age, sex and obesity. J. Gerontol. 44: M66–M73, 1989.

    CAS  PubMed  Google Scholar 

  53. Folsom A.R., Kaye S.A., Sellers T.A., Hong C.P., Cerhan J.R., Potter J.D., Prineas R.J.: Body fat distribution and 5-year risk of death in older women. JAMA 269: 483–487, 1993.

    CAS  PubMed  Google Scholar 

  54. Larsson B., Svardsudd K., Welin L., Wihelmsen L., Bjorntorp P., Tibblin G.: Abdominal adipose tissue distribution, obesity and risk of cardiovascular disease and death: 13-year follow-up of participants in the study of men born in 1913. Br. Med. J. 289: 1257–1261, 1984.

    Google Scholar 

  55. Poehlman E.T., Toth M.J., Bunyard L.B., Gardner A.W., Donaldson K.E., Colman E., Fonong T., Ades F.A.: Physiological predictors of increasing total and central adiposity in aging men and women. Arch. Intern. Med. 155: 2443–2448, 1995.

    CAS  PubMed  Google Scholar 

  56. Kohrt W.M., Malley M.T., Dalsky G.P., Holloszy J.O.: Body composition of healthy sedentary and trained, young and older women. Med. Sci. Sports Exerc. 24: 832–837, 1991.

    Google Scholar 

  57. Pollock M.L., Foster C., Knapp D., Rod J.L., Schmidt T.H.: Effect of age, training and competition on aerobic capacity and body composition of master athletes. J. Appl. Physiol. 62: 725–731, 1987.

    CAS  PubMed  Google Scholar 

  58. Kohrt W.M., Obert K.A., Holloszy J.O.: Exercise training improves fat distribution patterns in 60- to 70-year-old men and women. J. Gerontol. 47: M99–M105, 1992.

    CAS  PubMed  Google Scholar 

  59. Schwartz R.S., Shumann W.P., Larson V., Cain K.C., Fellingham G.W., Beard J.C., Kahn S.E., Stratton J.R., Cerqueira M.D., Abbrass I.B.: The effect of intensive endurance exercise training on body fat distribution in young and older men. Metabolism 40: 545–551, 1991.

    CAS  PubMed  Google Scholar 

  60. Applegate W.B.: Hypertension. In: Hazzard W.R., Bierman E.L., Blass J.P., Ettinger Jr. W.H., Halter J.B. (Eds.), Principles of Geriatric Medicine and Gerontology, ed. 3. McGraw-Hill Book Company, New York, 1994, pp. 541–554.

    Google Scholar 

  61. Paffenbarger R.S., Jung D.L., Leung R.W., Hyde R.T.: Physical activity and hypertension: an epidemiological view. Ann. Med. 23: 319–327, 1991.

    PubMed  Google Scholar 

  62. Seals D.R., Hagberg J.M.: The effects of exercise training on human hypertension: a review. Med. Sci. Sports Exerc. 16: 207–215, 1984.

    CAS  PubMed  Google Scholar 

  63. Braith R.W., Pollock M.L., Lowenthal D.T., Graves J.E., Limacher M.: Moderate and high-intensity exercise lowers blood pressure in normotensive subjects 60 to 79 years of age. Am. J. Cardiol. 73: 1124–1128, 1994.

    CAS  PubMed  Google Scholar 

  64. Hagberg J.M., Montain S.J., Martin W.H., Eshani A.A.: Effect of exercise training in 60 to 69-year-old persons with essential hypertension. Am. J. Cardiol. 64: 348–353, 1989.

    CAS  PubMed  Google Scholar 

  65. Harris M.I., Hadden W.C., Knowler W.C., Bennet P.H.: Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in the U.S.A. population aged 20-74 years. Diabetes 36: 523–534, 1987.

    CAS  PubMed  Google Scholar 

  66. Nathan D.M., Singer D.E., Godine J.E., Perlmuter L.C.: Non-insulin dependent diabetes mellitus in older patients. Complications and risk factors. Am. J. Med. 81: 837–842, 1985.

    Google Scholar 

  67. Shimokata H., Muller D.C., Fleg J.L., Sorkin J., Ziemba A.V., Andres R.: Age as independent determinant of glucose tolerance. Diabetes 40: 44–51, 1991.

    CAS  PubMed  Google Scholar 

  68. Lonnroth P., Smith U.: Aging enhances the insulin resistance in obesity through receptor and postreceptor alterations. J. Clin. Endocrinol. Metab. 62: 433–437, 1986.

    CAS  PubMed  Google Scholar 

  69. Fink R.I., Kolterman O.G., Griffin J., Olefsky J.M.: Mechanisms of insulin resistance in aging. J. Clin. Invest. 71: 1523–1535, 1983.

    CAS  PubMed Central  PubMed  Google Scholar 

  70. Coon P.J., Rogus E.M., Drinkwater D., Muller D.C., Goldberg A.P.: Role of body fat distribution in the decline of insulin sensitivity and glucose tolerance with aging. J. Clin. Endocrinol. Metab. 75: 1125–1132, 1992.

    CAS  PubMed  Google Scholar 

  71. Seals D.R., Hagberg J.M., Allen W.K., Hurley B.F., Dalsky G.P., Ehsani A.A., Holloszy J.O.: Glucose tolerance in young and older athletes and sedentary men. J. Appl. Physiol. 56: 1521–1525, 1984.

    CAS  PubMed  Google Scholar 

  72. Kahn S.E., Larson V.G., Beard J.C., Cain K.C., Fellingham G.W., Schwartz R.S., Veith R.C., Stratton J.R., Cerqueira M.D., Abrass I.B.: Effect of exercise on insulin action, glucose intolerance and insulin secretion in aging. Am. J. Physiol. 258: E937–E943, 1990.

    CAS  PubMed  Google Scholar 

  73. Kirwin J.P., Kohrt W.M., Wojta D.M., Bourney R.E., Holloszy J.O.: Endurance exercise training reduces glucose stimulated insulin levels in 60-70 year-old men and women. J. Gerontol. 48: M84–M90, 1993.

    Google Scholar 

  74. Miller J.P., Pratley R.E., Goldberg A.P., Gordon P., Rubin M., Treuth M.S., Ryan A.S., Hurley B.F.: Strength training increases insulin action in healthy 50 to 65 yr old men. J. Appl. Physiol. 77: 1122–1127, 1994.

    CAS  PubMed  Google Scholar 

  75. Helmrich S.P., Ragland D.R., Leung R.W., Paffenbarger R.S. Jr.: Physical activity and reduced occurrence of non insulin dependent diabetes mellitus. N. Engl. J. Med. 325: 147–152, 1991.

    CAS  PubMed  Google Scholar 

  76. Manson J.E., Rimm E.B., Stampfer M.J., Colditz G.A., Willett W.C., Krolewski A.S., Rosner B., Hennekens C.H., Speizer F.E.: Physical activity and incidence of non insulin dependent diabetes mellitus in women. Lancet 338: 774–778, 1991.

    CAS  PubMed  Google Scholar 

  77. Gurwitz J.H., Field R.S., Glynn R.J., Manson J.E., Avorn J., Taylor J.O., Hennekens C.H.: Risk factors for non-insulin dependent diabetes mellitus requiring treatment in the elderly. J. Am. Geriatr. Soc. 42: 1235–1240, 1994.

    CAS  PubMed  Google Scholar 

  78. Manson J.E., Nathan D.M., Kralewski A.S., Stampfler M.S., Willet W.C., Hennekens C.H.: A prospective study of exercise and incidence of diabetes mellitus among US male physicians. JAMA 268: 63–67, 1992.

    CAS  PubMed  Google Scholar 

  79. National Center for Health Statistics: Vital Statistics of the United States 1989. Vol II. Mortality. Part A. Government Printing Office. DHHS Publication no. (PHS) 93-1101, Washington, D.C., 1993.

  80. Ettinger W.H., Fried L.P., Harris T., Shemanski L., Schultz R., Robbins J.: Self-reported causes of physical disability in older people. J. Am. Geriatr. Soc. 42: 1035–1044, 1994.

    PubMed  Google Scholar 

  81. Schneider S.H., Vitug A., Ruderman N.: Atherosclerosis and physical exercise. Diabetes Metab. Rev. 1: 513, 1986.

    CAS  PubMed  Google Scholar 

  82. Berlin J.A., Colditz A.G.: A meta-analysis of physical activity in the prevention of coronary heart disease. Am. J. Epidemiol. 132: 612–628, 1990.

    CAS  PubMed  Google Scholar 

  83. Langer R.D., Klauber M.R., Criqui M.H., Barrett-Connor E.R.: Exercise and survival in the very old. Amer. J. Geriatr. Cardiol. 3: 24–34, 1994.

    Google Scholar 

  84. Grand A., Grosclaude P., Bocquet H., Pous J., Albarede J.L.: Disability, psychosocial factors and mortality among the elderly in a rural French population. J. Clin. Epidemiol. 43: 773–782, 1990.

    CAS  PubMed  Google Scholar 

  85. Ruigómez A., Alonso J., Antó J.M.: Relationship of health behaviors to five-year mortality in an elderly cohort. Age Ageing 24: 113–120, 1995.

    PubMed  Google Scholar 

  86. Blair S.N., Kohl H.W. III, Paffenbarger R.S. Jr., Clark D.G., Cooper K.H., Gibbons L.W.: Physical fitness and all-cause mortality. JAMA 262: 2395–2401, 1989.

    CAS  PubMed  Google Scholar 

  87. Sandvik L., Erikssen J., Thaulow E., Erikssen G., Mundal R., Rodhal K.: Physical fitness as a predictor of mortality among healthy, middle-aged Norwegian men. N. Engl. J. Med. 328: 533–537, 1993.

    CAS  PubMed  Google Scholar 

  88. Curfman G.D.: The health benefits of exercise: a critical reappraisal. N. Engl. J. Med. 328: 574–576, 1993.

    CAS  PubMed  Google Scholar 

  89. Rodriguez B.L., Curb D., Burchfiel C.M., Abbott R.D., Petrovich H., Masaki K., Chiu D.: Physical activity and 23-year incidence of coronary heart disease morbidity and mortality among middle-aged men. Circulation 89: 2540–2544, 1994.

    CAS  PubMed  Google Scholar 

  90. Simoes E.J., Byers T., Coates R.J., Serdula M.K., Mokdad A.H., Heath G.W.: The association between leisure-time physical activity and dietary fat in American adults. Am. J. Public Health 85: 240–244, 1995.

    CAS  PubMed  Google Scholar 

  91. Fogelholm J., Kaprio J., Sarna S.: Healthy lifestyles of former Finnish world class athletes. Med. Sci. Sports Exerc. 25: 224–229, 1994.

    Google Scholar 

  92. Hein H.O., Suadicani P., Gyntelberg F.: Physical fitness or physical activity as a predictor of ischemic heart disease?: A 17-year follow-up in the Copenhagen Male Study. J. Intern. Med. 232: 471–479, 1992.

    CAS  PubMed  Google Scholar 

  93. Paffenbarger R.S., Hyde R.T., Wing A.L., Hsieh C.: Physical activity, all-cause mortality, and longevity of college alumni. N. Engl. J. Med. 314: 605–613, 1986.

    PubMed  Google Scholar 

  94. Paffenbarger R.S., Hyde R.T., Wing A.L., Lee I., Jung D., Kampert J.: The association of changes in physical-activity level and other life-style characteristics with mortality among men. N. Engl. J. Med. 328: 538–545, 1993.

    PubMed  Google Scholar 

  95. Blair S.N., Kohl H.W., Barlow C.E., Paffenbarger R.S., Gibbons L.W., Macera C.A.: Changes in physical fitness and all-cause mortality. A prospective study in healthy and unhealthy men. JAMA 273: 1093–1098, 1995.

    CAS  PubMed  Google Scholar 

  96. Fletcher G.F., Blair S.N., Blumenthal J., Caspersen C., Chaitman B., Epstein S., Falls H., Froelicher E.S., Froelicher V.F., Pina I.L.: Statement on exercise: Benefits and recommendations for physical activity for all Americans. Circulation 86: 340–344, 1992.

    CAS  PubMed  Google Scholar 

  97. Morris J.N., Clayton D.G., Everitt M.G., Semmence A.M., Burgess E.H.: Vigorous exercise in leisure time and the incidence of coronary heart disease. Br. Heart J. 63: 325–334, 1990.

    CAS  PubMed Central  PubMed  Google Scholar 

  98. Lee I.M., Hsieh C.C., Paffenbarger R.S.: Exercise intensity and longevity in men. The Harvard alumni study. JAMA 273: 1179–1184, 1995.

    CAS  PubMed  Google Scholar 

  99. Leon A.S., Connett J., Jacobs D.R., Rauramaa R.: Leisure time physical activity levels and risk of coronary heart disease and death: The Multiple Risk Factor Intervention Trial. JAMA 258: 2388–2395, 1987.

    CAS  PubMed  Google Scholar 

  100. Haskell W.L.: Health consequences of physical activity: understanding and challenges regarding dose-response. Med. Sci. Sports Exerc. 26: 649–660, 1994.

    CAS  PubMed  Google Scholar 

  101. La Croix A.Z., Leveille S.G., Hecht J.A., Grothaus L.C., Wagner E.H.: Does walking decrease the risk of cardiovascular disease hospitalization and death in older adults? J. Am. Geriatr. Soc. 44: 113–120, 1996.

    Google Scholar 

  102. Corti M.C., Guralnik J.M., Bilato C.: Coronary heart disease risk factors in older persons. Aging Clin. Exp. Res. 8: 75–89, 1996.

    CAS  Google Scholar 

  103. Stratton J.R., Wayne L.C., Schwartz R.S., Cerqueira M.D., Levy M.C., Kahn S.E., Larson V.G., Cain K.C., Bard J.C., Abrass I.B.: Effects of physical conditioning on fibrinolytic variables and fibrinogen in young and old healthy adults. Circulation 83: 1692–1697, 1991.

    CAS  PubMed  Google Scholar 

  104. Rankine T., Rauramaa R., Väisänen S., Halonen P., Penttilä I.M.: Blood coagulation and fibrinolytic factors are unchanged by aerobic exercise or fat modified diet. Fibrinolysis 8: 48–53, 1994.

    Google Scholar 

  105. Curfman G.D.: Is exercise beneficial or hazardous for your heart? N. Engl. J. Med. 329: 1730–1731, 1993.

    CAS  PubMed  Google Scholar 

  106. O’Connor G.T., Buring J.E., Yusuf S., Goldhaber S.Z., Olmstead E.M., Paffenbarger R.S. Jr., Hennekens C.H.: An overview of randomized trials of rehabilitation with exercise after myocardial infarction. Circulation 80: 234–244, 1989.

    PubMed  Google Scholar 

  107. Lavie C.J., Milani R.V.: Effects of cardiac rehabilitation programs on exercise capacity, coronary risk factors, behavioral characteristics and quality of life in a large elderly cohort. Am. Heart J. 76: 177–179, 1995.

    CAS  Google Scholar 

  108. Ades P.A., Waldmann M.L., Meyer W.L., Brown K.A., Poehlman E.T., Pendlebury W.W., Leslie K.O., Gray P.R., Lew R.R., LeWinter M.M.: Skeletal muscle and cardiovascular adaptations to exercise conditioning in older coronary patients. Circulation 94: 323–330, 1996.

    CAS  PubMed  Google Scholar 

  109. Guidelines for Cardiac Rehabilitation Programs. American Association of Cardiovascular and Pulmonary Rehabilitation Programs, ed. 2. Human Kinetics Publishers, Chaimpaign, IL, 1994.

  110. Haskell W.L.: The efficacy and safety of exercise programs in cardiac rehabilitation. Med. Sci. Sports Exerc. 26: 815–823, 1994.

    CAS  PubMed  Google Scholar 

  111. Hanson P.: Exercise testing and training in patients with chronic heart failure. Med. Sci. Sports Exerc. 26: 527–537, 1994.

    CAS  PubMed  Google Scholar 

  112. McKelvie R.S., Teo K.K., McKartney N., Humen D., Montague T., Yusuf S.: Effects of exercise training in patients with congestive heart failure: A critical review. J. Am. Coll. Cardiol. 25: 789–796, 1995.

    CAS  PubMed  Google Scholar 

  113. Keteyian S.J., Levine A.B., Brawner C.A., Kataoka T., Rogers F.J., Schairer J.R., Stein P.D., Levine T.B., Goldstein S.: Exercise training in patients with heart failure. A randomized controlled trial. Ann. Intern. Med. 124: 1051–1057, 1996.

    CAS  PubMed  Google Scholar 

  114. Hiatt W.R., Regenstreiner J.G., Hargarten M.E., Wolfel E.E., Brass E.P.: Benefit of exercise conditioning for patients with peripheral artery disease. Circulation 81: 602–609, 1990.

    CAS  PubMed  Google Scholar 

  115. Regenstreiner J.G., Steiner J.F., Hiatt W.R.: Exercise training improves functional status in patients with peripheral artery disease. J. Vasc. Surg. 23: 104–115, 1996.

    Google Scholar 

  116. Hiatt W.R., Wolfel E.E., Meier R.H., Regenstreiner J.G.: Superiority of treadmill walking exercise versus strength training for patients with peripheral artery disease. Implications for the mechanisms of training response. Circulation 90: 1866–1874, 1994.

    CAS  PubMed  Google Scholar 

  117. Bonita R.: Epidemiology of stroke. Lancet 339: 342–347, 1992.

    CAS  PubMed  Google Scholar 

  118. Wannamethee G., Shaper A.G.: Physical activity and stroke in British middle aged men. Br. Med. J. 304: 597–601, 1992.

    CAS  Google Scholar 

  119. Shinton R., Sagar G.: Lifelong exercise and stroke. Br. Med. J. 307: 231–234, 1993.

    CAS  Google Scholar 

  120. Kiely D.K., Wolf P.A., Cupples L.A., Beiser A.S., Kannel W.B.: Physical activity and stroke risk: The Framingham Study. Am. J. Epidemiol. 140: 608–620, 1994.

    CAS  PubMed  Google Scholar 

  121. Abott R.D., Rodriguez B.L., Burchfield C.M., Curb J.D.: Physical activity in older middle-aged men and reduced risk of stroke: The Honolulu Heart Program. Am. J. Epidemiol. 139: 881–893, 1994.

    Google Scholar 

  122. Gillum R.F., Mussolino M.E., Ingram D.D.: Physical activity and stroke incidence in women and men. The NANHES I epidemiologic follow-up study. Am. J. Epidemiol. 143: 860–869, 1996.

    CAS  PubMed  Google Scholar 

  123. Potempa K., Lopez M., Braun L.T., Szidon P., Fogg L., Tinknell T.: Physiological outcomes of aerobic exercise training in hemiparetic stroke patients. Stroke 26: 101–105, 1995.

    CAS  PubMed  Google Scholar 

  124. Elward K., Larson E.B.: Benefits of exercise for older adults. Clin. Geriatr. Med. 8: 35–50, 1992.

    CAS  PubMed  Google Scholar 

  125. Yusuf H.R., Croft J.B., Giles W.H., Anda R.F., Casper M.L., Caspersen C.J., Jones D.A.: Leisure-time physical activity among older adults. Arch. Intern. Med. 156: 1321–1326, 1996.

    CAS  PubMed  Google Scholar 

  126. Crespo C.J., Keteyian S.J., Heath G.W., Sempos C.T.: Leisure-time physical activity among US adults. Results from the third National Health and Nutrition Examination Survey. Arch. Intern. Med. 156: 93–98, 1996.

    CAS  PubMed  Google Scholar 

  127. Pate R.R., Pratt M., Blair S., Haskell W.L., Macera C.A., Bouchard C., Buchner D., Ettinger W., Heath G.W., King A.C., Kriska A., Leon A.S., Markus B.H., Morris J., Paffenbarger R.S., Patrick K., Pollock M., Rippe J.M., Sallis J., Wilmore J.H.: Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA 273: 402–407, 1995.

    CAS  PubMed  Google Scholar 

  128. Caspersen C.J., Kriska A.M., Dearwater S.R.: Physical activity epidemiology as applied to the elderly populations. Baillieres Clin. Rheumatol. 8: 7–27, 1994.

    CAS  PubMed  Google Scholar 

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Cherubini, A., Lowenthal, D.T., Williams, L.S. et al. Physical activity and cardiovascular health in the elderly. Aging Clin Exp Res 10, 13–25 (1998). https://doi.org/10.1007/BF03339629

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